Patterns of Epistasis between beneficial mutations in an antibiotic resistance gene. - Test2 - elhamkhani - TriplyDB

Patterns of Epistasis between beneficial mutations in an antibiotic resistance gene.

Patterns of Epistasis between beneficial mutations in an antibiotic resistance gene.

http://www.wikidata.org/entity/Q41864870

about

What can we learn from fitness landscapes?Costs of antibiotic resistance - separating trait effects and selective effects Environmental changes bridge evolutionary valleys Coordinated Evolution of Influenza A Surface Proteins Steering Evolution with Sequential Therapy to Prevent the Emergence of Bacterial Antibiotic Resistance The Valley-of-Death: reciprocal sign epistasis constrains adaptive trajectories in a constant, nutrient limiting environment Widespread Genetic Incompatibilities between First-Step Mutations during Parallel Adaptation of Saccharomyces cerevisiae to a Common Environment Detecting High-Order Epistasis in Nonlinear Genotype-Phenotype Maps Epistatically interacting substitutions are enriched during adaptive protein evolution Stability-Mediated Epistasis Restricts Accessible Mutational Pathways in the Functional Evolution of Avian Hemoglobin.Causes of molecular convergence and parallelism in protein evolution.Coevolutionary Landscape Inference and the Context-Dependence of Mutations in Beta-Lactamase TEM-1.CBMAR: a comprehensive β-lactamase molecular annotation resource.A systematic survey of an intragenic epistatic landscape.Properties of selected mutations and genotypic landscapes under Fisher's geometric model.Mapping the fitness landscape of gene expression uncovers the cause of antagonism and sign epistasis between adaptive mutations.Role of pleiotropy during adaptation of TEM-1 β-lactamase to two novel antibiotics.A tortoise-hare pattern seen in adapting structured and unstructured populations suggests a rugged fitness landscape in bacteria Delayed commitment to evolutionary fate in antibiotic resistance fitness landscapes.Overcoming an optimization plateau in the directed evolution of highly efficient nerve agent bioscavengers.How Good Are Statistical Models at Approximating Complex Fitness Landscapes?On the (un)predictability of a large intragenic fitness landscape.Molecular and Proteomic Analysis of Levofloxacin and Metronidazole Resistant Helicobacter pylori.Increased expression of the frontotemporal dementia risk factor TMEM106B causes C9orf72-dependent alterations in lysosomes.TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions.Empirical fitness landscapes and the predictability of evolution.Fighting microbial drug resistance: a primer on the role of evolutionary biology in public health Genotypic Complexity of Fisher's Geometric Model.The rule of declining adaptability in microbial evolution experiments.Epistasis and the Structure of Fitness Landscapes: Are Experimental Fitness Landscapes Compatible with Fisher's Geometric Model?Adaptation in tunably rugged fitness landscapes: the rough Mount Fuji model.Strong epistatic interactions within a single protein.Adaptive multiscapes: an up-to-date metaphor to visualize molecular adaptation.Negative Epistasis and Evolvability in TEM-1 β-Lactamase--The Thin Line between an Enzyme's Conformational Freedom and Disorder.Multiple Resistance at No Cost: Rifampicin and Streptomycin a Dangerous Liaison in the Spread of Antibiotic Resistance.Adaptive Landscapes of Resistance Genes Change as Antibiotic Concentrations Change.Selecting among three basic fitness landscape models: Additive, multiplicative and stickbreaking.Compensatory mutations and epistasis for protein function.Slow and temperature-mediated pathogen adaptation to a nonspecific fungicide in agricultural ecosystem.Local Fitness Landscapes Predict Yeast Evolutionary Dynamics in Directionally Changing Environments.

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Patterns of Epistasis between beneficial mutations in an antibiotic resistance gene.

http://www.wikidata.org/entity/Q41864870

description

2013 nî lūn-bûn

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2013年の論文

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2013年論文

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2013年论文

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2013年论文

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2013年论文

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Patterns of Epistasis between beneficial mutations in an antibiotic resistance gene.

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Patterns of Epistasis between beneficial mutations in an antibiotic resistance gene.

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Patterns of Epistasis between beneficial mutations in an antibiotic resistance gene.

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Molecular Biology and Evolution

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Patterns of Epistasis between beneficial mutations in an antibiotic resistance gene.

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P2093

Ivan G Szendro

http://www.w3.org/2001/XMLSchema#string

J Arjan G M de Visser

http://www.w3.org/2001/XMLSchema#string

Joachim Krug

http://www.w3.org/2001/XMLSchema#string

Martijn F Schenk

http://www.w3.org/2001/XMLSchema#string

Merijn L M Salverda

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P2860

Predictability of evolutionary trajectories in fitness landscapes

Quantifying the adaptive potential of an antibiotic resistance enzyme

Genomic analysis of a key innovation in an experimental Escherichia coli population

Second-order selection for evolvability in a large Escherichia coli population

The causes of epistasis

Evolution of an antibiotic resistance enzyme constrained by stability and activity trade-offs

The genetic landscape of a cell

Darwinian evolution can follow only very few mutational paths to fitter proteins

Positive epistasis drives the acquisition of multidrug resistance.

Colloquium papers: Adaptive landscapes and protein evolution.

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1779-1787

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scholarly article

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10.1093/MOLBEV/MST096

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8

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30

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2013-05-15T00:00:00Z

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236911511

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23676768

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3708503

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