Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization - Test2 - elhamkhani - TriplyDB

Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization

Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization

http://www.wikidata.org/entity/Q42800693

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BAK multimerization for apoptosis, but not bid binding, is inhibited by negatively charged residue in the BAK hydrophobic groove COMMD1 is linked to the WASH complex and regulates endosomal trafficking of the copper transporter ATP7A BID-induced structural changes in BAK promote apoptosis Mitochondrial apoptosis and BH3 mimetics Casp8p41 generated by HIV protease kills CD4 T cells through direct Bak activation Building blocks of the apoptotic pore: how Bax and Bak are activated and oligomerize during apoptosis Charge profile analysis reveals that activation of pro-apoptotic regulators Bax and Bak relies on charge transfer mediated allosteric regulation Histone deacetylase inhibitors interrupt HSP90•RASGRP1 and HSP90•CRAF interactions to upregulate BIM and circumvent drug resistance in lymphoma cells The rheostat in the membrane: BCL-2 family proteins and apoptosis Platelet-derived growth factor primes cancer-associated fibroblasts for apoptosis.Beta-amyloid oligomers activate apoptotic BAK pore for cytochrome c release.Blockade of the BAK hydrophobic groove by inhibitory phosphorylation regulates commitment to apoptosis.Novel small-molecule inhibitors of Bcl-XL to treat lung cancer.Mitochondria and apoptosis: emerging concepts.Ligand binding and membrane insertion compete with oligomerization of the BclXL apoptotic repressor Bak Conformational Changes Induced by Ligand Binding: Insight into BH3 Domain Binding and Bak Homo-Oligomerization Translocation of a Bak C-terminus mutant from cytosol to mitochondria to mediate cytochrome C release: implications for Bak and Bax apoptotic function.Bax dimerizes via a symmetric BH3:groove interface during apoptosis BH3-only proteins in apoptosis at a glance An interconnected hierarchical model of cell death regulation by the BCL-2 family Unlocking Pandora's box: personalising cancer cell death in non-small cell lung cancer.Constitutive BAK activation as a determinant of drug sensitivity in malignant lymphohematopoietic cells.Bid chimeras indicate that most BH3-only proteins can directly activate Bak and Bax, and show no preference for Bak versus Bax.P53 Regulates Rapid Apoptosis in Human Pluripotent Stem Cells.Bak apoptotic function is not directly regulated by phosphorylation.Evolution of Bcl-2 homology motifs: homology versus homoplasy.Direct activation of full-length proapoptotic BAK Mitochondria in human pluripotent stem cell apoptosis.MLN4924 induces Noxa upregulation in acute myelogenous leukemia and synergizes with Bcl-2 inhibitors.Inactivation of prosurvival Bcl-2 proteins activates Bax/Bak through the outer mitochondrial membrane.Identification of an activation site in Bak and mitochondrial Bax triggered by antibodies.CXCR4 chemokine receptor signaling induces apoptosis in acute myeloid leukemia cells via regulation of the Bcl-2 family members Bcl-XL, Noxa, and Bak Assembly of the Bak apoptotic pore: a critical role for the Bak protein α6 helix in the multimerization of homodimers during apoptosis Multimodal interaction with BCL-2 family proteins underlies the proapoptotic activity of PUMA BH3 Evaluation of the BH3-only protein Puma as a direct Bak activator Computationally designed high specificity inhibitors delineate the roles of BCL2 family proteins in cancer.Deciphering the rules of programmed cell death to improve therapy of cancer and other diseases The fourth dimension in immunological space: how the struggle for nutrients selects high-affinity lymphocytes.Many players in BCL-2 family affairs.The Bcl-2 family: structures, interactions and targets for drug discovery.

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P2860

Transient binding of an activator BH3 domain to the Bak BH3-binding groove initiates Bak oligomerization

http://www.wikidata.org/entity/Q42800693

description

2011 nî lūn-bûn

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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2011年论文

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2011年论文

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name

Transient binding of an activa ...... initiates Bak oligomerization

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Transient binding of an activa ...... initiates Bak oligomerization

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type

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Transient binding of an activa ...... initiates Bak oligomerization

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Transient binding of an activa ...... initiates Bak oligomerization

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prefLabel

Transient binding of an activa ...... initiates Bak oligomerization

@en

Transient binding of an activa ...... initiates Bak oligomerization

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Journal of Cell Biology

P1476

Transient binding of an activa ...... initiates Bak oligomerization

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P2093

Alyson Smith

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Paula A Schneider

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X Wei Meng

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P2860

Structure of HI-6*sarin-acetylcholinesterase determined by X-ray crystallography and molecular dynamics simulation: reactivator mechanism and design

tBID, a membrane-targeted death ligand, oligomerizes BAK to release cytochrome c

Apoptosis initiated when BH3 ligands engage multiple Bcl-2 homologs, not Bax or Bak

Noxa/Bcl-2 protein interactions contribute to bortezomib resistance in human lymphoid cells

Membrane remodeling induced by the dynamin-related protein Drp1 stimulates Bax oligomerization

BH3 domains other than Bim and Bid can directly activate Bax/Bak

A stapled BID BH3 helix directly binds and activates BAX

Membrane binding by tBid initiates an ordered series of events culminating in membrane permeabilization by Bax

Molecular cloning and characterization of a cDNA for a novel phorbol-12-myristate-13-acetate-responsive gene that is highly expressed in an adult T-cell leukemia cell line

The SWISS-MODEL Repository and associated resources

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39-48

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10.1083/JCB.201102027

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1

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194

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Scott H Kaufmann

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2011-07-04T00:00:00Z

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51465388

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21727192

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3135403

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