The fragile X mental retardation protein FMRP binds elongation factor 1A mRNA and negatively regulates its translation in vivo.
about
Multiple autism-linked genes mediate synapse elimination via proteasomal degradation of a synaptic scaffold PSD-95Fragile X syndrome: loss of local mRNA regulation alters synaptic development and functionDendritic BC1 RNA in translational control mechanismsDendritic mRNAs encode diversified functionalities in hippocampal pyramidal neuronsRNA Secondary Structure Modulates FMRP's Bi-Functional Role in the MicroRNA PathwayRegulatory BC1 RNA and the fragile X mental retardation protein: convergent functionality in brainBiochemical and genetic interaction between the fragile X mental retardation protein and the microRNA pathwayFrom FMRP function to potential therapies for fragile X syndrome.Fragile X mental retardation protein is required for programmed cell death and clearance of developmentally-transient peptidergic neurons.Identification of FMRP-associated mRNAs using yeast three-hybrid system.Fragile x mental retardation protein regulates proliferation and differentiation of adult neural stem/progenitor cells.Specific interaction between Sam68 and neuronal mRNAs: implication for the activity-dependent biosynthesis of elongation factor eEF1A.Genetic controls balancing excitatory and inhibitory synaptogenesis in neurodevelopmental disorder models.Translational control of mGluR-dependent long-term depression and object-place learning by eIF2α.A metabolomic and systems biology perspective on the brain of the fragile X syndrome mouse modelRNA transport and local control of translation.Translational control at the synapse.Generation of polyclonal antiserum for the detection of methylarginine proteins.New X-chromosomal interactors of dFMRP regulate axonal and synaptic morphology of brain neurons in Drosophila melanogasterTemporal requirements of the fragile x mental retardation protein in modulating circadian clock circuit synaptic architecture.The fragile X mental retardation protein in circadian rhythmicity and memory consolidation.The state of synapses in fragile X syndrome.Metabotropic glutamate receptor-mediated long-term depression: molecular mechanisms.Heads-up: new roles for the fragile X mental retardation protein in neural stem and progenitor cells.Defects in translational regulation contributing to human cognitive and behavioral disease.Drosophila fragile X mental retardation protein developmentally regulates activity-dependent axon pruning.Mechanistic relationships between Drosophila fragile X mental retardation protein and metabotropic glutamate receptor A signaling.FMRP-dependent Mdm2 dephosphorylation is required for MEF2-induced synapse elimination.Recombinant bacterial expression and purification of human fragile X mental retardation protein isoform 1.Conformational-dependent and independent RNA binding to the fragile x mental retardation protein.Computational identification and experimental validation of microRNAs binding to the fragile X syndrome gene Fmr1.mGluR-dependent long-term depression is associated with increased phosphorylation of S6 and synthesis of elongation factor 1A but remains expressed in S6K-deficient mice.Metabotropic receptor-dependent long-term depression persists in the absence of protein synthesis in the mouse model of fragile X syndrome.Fragile X mental retardation protein recognizes a G quadruplex structure within the survival motor neuron domain containing 1 mRNA 5'-UTR.G Protein-Coupled Receptors As Regulators of Localized Translation: The Forgotten Pathway?
P2860
Q24306675-416C7306-A08C-4B5D-91C1-AC63A286F2CEQ24608468-848B4C71-A36C-4787-8AF0-A03858B83DCBQ24678623-5B106226-C400-44A4-ACB2-D1D098757B24Q25256777-D5F9D8F8-6BBC-45BD-9B82-950DE0E71E8CQ26747489-DEDCB715-119F-4D9F-825B-3432C29645F0Q27312243-D2D0990C-3E97-4D73-A3AA-AD655015C79EQ28236951-9717362D-DBEF-4D8A-BBA7-86ADB18A9116Q30410502-86E53014-A80C-4321-AB13-EE4F0F798368Q30502814-FEE83240-BE7B-49CF-BFE9-0168213B5623Q33312588-40A364D3-2146-4578-B89D-FE2D4701EE2BQ33553437-E6CC9C6D-BDA5-43A4-832A-59BFE68B3573Q33732364-060FFCA7-7D21-4558-9C01-4AC6DFD6D283Q34689960-286EECD9-A746-4255-BB8A-7B41CF636408Q35121843-89586EA8-B23D-4D15-A03B-81FAEE053145Q35581584-B079F200-37FF-4BA5-80FC-7C541C5C9751Q35748358-E4269A74-E664-44F6-AA1D-E087E1AF4FB0Q35919452-D6F9E072-2901-4663-B74A-A9C173C13E43Q35945148-95AA6E66-949C-4C36-B978-EA997362BF00Q36384227-31FB7E14-89D1-4EFF-A02A-57B44ADB77FDQ37332148-234A6320-E4DF-47EF-832B-B674FC34FE7BQ37359934-08035C4D-6A3D-4195-8A4D-0A36BF417758Q37387721-AC0DF3AB-AD3A-4A06-91D5-8FB7D46158C2Q37635588-FA04B509-05F7-4996-AD49-126135BF47CCQ37853118-DE295731-95EE-4AB7-8C63-DB2D328C6FDBQ37901907-B6A41A76-3CB6-4410-BD6A-E080A31B2269Q38292954-1FC784F0-1F3C-4EB0-911A-EA59458048F4Q38802671-3DFE6C42-10AE-4434-B274-218B07DA6724Q39063317-76C43F70-D203-4417-8223-31A53355A05DQ41773333-84F0CBE1-A02C-4A29-8594-4C3078485961Q42095288-9877E7A7-71DD-4C78-8C8D-32E1CC92D0C8Q42182020-F45250B1-40D5-41D8-9A07-D990CB9ED1D4Q42525384-8865DEB2-D7AC-448D-BE99-494B120F3338Q46923253-5ADA8F0B-30CC-47A1-AABF-48950A45FE59Q47694428-939958B0-6213-4218-AF95-CB9999CAC9F4Q49884948-BB3B2FEF-069E-47EC-A4C2-8976E6E0907D
P2860
The fragile X mental retardation protein FMRP binds elongation factor 1A mRNA and negatively regulates its translation in vivo.
description
2003 nî lūn-bûn
@nan
2003年の論文
@ja
2003年学术文章
@wuu
2003年学术文章
@zh
2003年学术文章
@zh-cn
2003年学术文章
@zh-hans
2003年学术文章
@zh-my
2003年学术文章
@zh-sg
2003年學術文章
@yue
2003年學術文章
@zh-hant
name
The fragile X mental retardati ...... lates its translation in vivo.
@en
The fragile X mental retardati ...... lates its translation in vivo.
@nl
type
label
The fragile X mental retardati ...... lates its translation in vivo.
@en
The fragile X mental retardati ...... lates its translation in vivo.
@nl
prefLabel
The fragile X mental retardati ...... lates its translation in vivo.
@en
The fragile X mental retardati ...... lates its translation in vivo.
@nl
P2093
P2860
P356
P1476
The fragile X mental retardati ...... lates its translation in vivo.
@en
P2093
Julia R Currie
Natalia Dolzhanskaya
Robert B Denman
Sarah L Nolin
Ying Ju Sung
P2860
P304
15669-15678
P356
10.1074/JBC.M211117200
P407
P577
2003-02-19T00:00:00Z