Metabotropic receptor-dependent long-term depression persists in the absence of protein synthesis in the mouse model of fragile X syndrome. - Test2 - elhamkhani - TriplyDB

Metabotropic receptor-dependent long-term depression persists in the absence of protein synthesis in the mouse model of fragile X syndrome.

Metabotropic receptor-dependent long-term depression persists in the absence of protein synthesis in the mouse model of fragile X syndrome.

http://www.wikidata.org/entity/Q46923253

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Calmodulin-kinases: modulators of neuronal development and plasticity Fragile X syndrome: loss of local mRNA regulation alters synaptic development and function Group 1 mGluR-dependent synaptic long-term depression: mechanisms and implications for circuitry and disease Advances in the treatment of fragile X syndrome Temporal requirements of the fragile X mental retardation protein in the regulation of synaptic structure mTOR signaling: at the crossroads of plasticity, memory and disease A new look at an old drug: neuroprotective effects and therapeutic potentials of lithium salts Clinical and Neurobiological Relevance of Current Animal Models of Autism Spectrum Disorders.Dysregulation of Mammalian Target of Rapamycin Signaling in Mouse Models of Autism Fragile X syndrome and targeted treatment trials.Learning and behavioral deficits associated with the absence of the fragile X mental retardation protein: what a fly and mouse model can teach us.The pathophysiology of fragile X (and what it teaches us about synapses)Fragile X-like behaviors and abnormal cortical dendritic spines in cytoplasmic FMR1-interacting protein 2-mutant mice.Haploinsufficiency of Cyfip1 produces fragile X-like phenotypes in mice Therapeutic Strategies in Fragile X Syndrome: From Bench to Bedside and Back Fragile X mental retardation protein: A paradigm for translational control by RNA-binding proteins Synaptic plasticity: multiple forms, functions, and mechanisms FMR1 transcript isoforms: association with polyribosomes; regional and developmental expression in mouse brain Bidirectional regulation of synaptic transmission by BRAG1/IQSEC2 and its requirement in long-term depression Elongation factor 2 and fragile X mental retardation protein control the dynamic translation of Arc/Arg3.1 essential for mGluR-LTD The FXG: a presynaptic fragile X granule expressed in a subset of developing brain circuits Phosphorylation of FMRP and alterations of FMRP complex underlie enhanced mLTD in adult rats triggered by early life seizures.Fragile X mental retardation protein deficiency leads to excessive mGluR5-dependent internalization of AMPA receptors Selective Disruption of Metabotropic Glutamate Receptor 5-Homer Interactions Mimics Phenotypes of Fragile X Syndrome in Mice.Behavioral changes following a single episode of early-life seizures support the latent development of an autistic phenotype.Stem cells and modeling of autism spectrum disorders.Modeling fragile X syndrome in the Fmr1 knockout mouse Ras signaling mechanisms underlying impaired GluR1-dependent plasticity associated with fragile X syndrome.Fragile X syndrome: mechanistic insights and therapeutic avenues regarding the role of potassium channels.Annual Research Review: Transgenic mouse models of childhood-onset psychiatric disorders.A mouse model of the human Fragile X syndrome I304N mutation.BC1 regulation of metabotropic glutamate receptor-mediated neuronal excitability.Lithium: a promising treatment for fragile X syndrome.Necessary, but not sufficient: insights into the mechanisms of mGluR mediated long-term depression from a rat model of early life seizures Meeting at the crossroads: common mechanisms in Fragile X and Down syndrome Dysregulation of group-I metabotropic glutamate (mGlu) receptor mediated signalling in disorders associated with Intellectual Disability and Autism mGluR5 positive allosteric modulators facilitate both hippocampal LTP and LTD and enhance spatial learning Genetic removal of matrix metalloproteinase 9 rescues the symptoms of fragile X syndrome in a mouse model.Characterization and reversal of synaptic defects in the amygdala in a mouse model of fragile X syndrome Altered mRNA transport, docking, and protein translation in neurons lacking fragile X mental retardation protein

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P2860

Metabotropic receptor-dependent long-term depression persists in the absence of protein synthesis in the mouse model of fragile X syndrome.

http://www.wikidata.org/entity/Q46923253

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Metabotropic receptor-dependen ...... e model of fragile X syndrome.

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Elena D Nosyreva

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Kimberly M Huber

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P2860

Altered synaptic plasticity in a mouse model of fragile X mental retardation

Fragile X mental retardation protein is translated near synapses in response to neurotransmitter activation

FMRP associates with polyribosomes as an mRNP, and the I304N mutation of severe fragile X syndrome abolishes this association

Evidence that fragile X mental retardation protein is a negative regulator of translation

A decade of molecular studies of fragile X syndrome

The fragile X syndrome protein FMRP associates with BC1 RNA and regulates the translation of specific mRNAs at synapses

From mRNP trafficking to spine dysmorphogenesis: the roots of fragile X syndrome

A characterisation of long-term depression induced by metabotropic glutamate receptor activation in the rat hippocampus in vitro

Deletion of FMR1 in Purkinje cells enhances parallel fiber LTD, enlarges spines, and attenuates cerebellar eyelid conditioning in Fragile X syndrome

The scaffold protein Homer1b/c links metabotropic glutamate receptor 5 to extracellular signal-regulated protein kinase cascades in neurons

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3291-3295

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10.1152/JN.01316.2005

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