Biochemical analysis of Angelman syndrome-associated mutations in the E3 ubiquitin ligase E6-associated protein.
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Angelman syndrome: insights into genomic imprinting and neurodevelopmental phenotypesFrom UBE3A to Angelman syndrome: a substrate perspectiveZn-binding AZUL domain of human ubiquitin protein ligase Ube3AMechanism of ubiquitin ligation and lysine prioritization by a HECT E3Altered social behavior and neuronal development in mice lacking the Uba6-Use1 ubiquitin transfer system.A coding-independent function of an alternative Ube3a transcript during neuronal development.Disrupted neuronal maturation in Angelman syndrome-derived induced pluripotent stem cells.The Angelman Syndrome protein Ube3A regulates synapse development by ubiquitinating arc.Angelman Syndrome.Catalytically Important Residues of E6AP Ubiquitin Ligase Identified Using Acid-Cleavable Photo-Cross-LinkersAn Autism-Linked Mutation Disables Phosphorylation Control of UBE3A.Neurodevelopmental Underpinnings of Angelman Syndrome.Identification and proteomic analysis of distinct UBE3A/E6AP protein complexes.Highbrow proteasome in high-throughput technology.GABAergic Neuron-Specific Loss of Ube3a Causes Angelman Syndrome-Like EEG Abnormalities and Enhances Seizure Susceptibility.A Drosophila model for Angelman syndrome.Role of the ubiquitin ligase E6AP/UBE3A in controlling levels of the synaptic protein ArcThe Angelman syndrome protein Ube3a/E6AP is required for Golgi acidification and surface protein sialylation.The active form of E6-associated protein (E6AP)/UBE3A ubiquitin ligase is an oligomer.Allelic specificity of Ube3a expression in the mouse brain during postnatal development.Genomic imprinting in development, growth, behavior and stem cellsFrom Prader-Willi syndrome to psychosis: translating parent-of-origin effects into schizophrenia research.Perturbed proteostasis in autism spectrum disorders.Early Origin and Evolution of the Angelman Syndrome Ubiquitin Ligase Gene Ube3a.Decreased Axon Caliber Underlies Loss of Fiber Tract Integrity, Disproportional Reductions in White Matter Volume, and Microcephaly in Angelman Syndrome Model Mice.Ubiquitin C-terminal electrophiles are activity-based probes for identification and mechanistic study of ubiquitin conjugating machinery.Different HECT domain ubiquitin ligases employ distinct mechanisms of polyubiquitin chain synthesis.Angelman syndrome-associated ubiquitin ligase UBE3A/E6AP mutants interfere with the proteolytic activity of the proteasome.Sequence determinants of E2-E6AP binding affinity and specificity.Neuronal overexpression of Ube3a isoform 2 causes behavioral impairments and neuroanatomical pathology relevant to 15q11.2-q13.3 duplication syndrome.Glial overexpression of Dube3a causes seizures and synaptic impairments in Drosophila concomitant with down regulation of the Na+/K+ pump ATPα.
P2860
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P2860
Biochemical analysis of Angelman syndrome-associated mutations in the E3 ubiquitin ligase E6-associated protein.
description
2004 nî lūn-bûn
@nan
2004年の論文
@ja
2004年学术文章
@wuu
2004年学术文章
@zh-cn
2004年学术文章
@zh-hans
2004年学术文章
@zh-my
2004年学术文章
@zh-sg
2004年學術文章
@yue
2004年學術文章
@zh
2004年學術文章
@zh-hant
name
Biochemical analysis of Angelm ...... ligase E6-associated protein.
@en
Biochemical analysis of Angelm ...... ligase E6-associated protein.
@nl
type
label
Biochemical analysis of Angelm ...... ligase E6-associated protein.
@en
Biochemical analysis of Angelm ...... ligase E6-associated protein.
@nl
prefLabel
Biochemical analysis of Angelm ...... ligase E6-associated protein.
@en
Biochemical analysis of Angelm ...... ligase E6-associated protein.
@nl
P2093
P2860
P356
P1476
Biochemical analysis of Angelm ...... n ligase E6-associated protein
@en
P2093
Amy W Hudson
Eric M Cooper
Joseph Amos
Joseph Wagstaff
P2860
P304
41208-41217
P356
10.1074/JBC.M401302200
P407
P577
2004-07-19T00:00:00Z