Rab29 activation of the Parkinson's disease-associated LRRK2 kinase. - Test2 - elhamkhani - TriplyDB

Rab29 activation of the Parkinson's disease-associated LRRK2 kinase.

Rab29 activation of the Parkinson's disease-associated LRRK2 kinase.

http://www.wikidata.org/entity/Q47150726

about

Back to the future: new target-validated Rab antibodies for evaluating LRRK2 signalling in cell biology and Parkinson's disease.Modeling Parkinson's Disease in Drosophila: What Have We Learned for Dominant Traits?Detection of endogenous S1292 LRRK2 autophosphorylation in mouse tissue as a readout for kinase activity.In Vitro Modeling of Leucine-Rich Repeat Kinase 2 (LRRK2) G2019S-Mediated Parkinson's Disease Pathology.The Parkinson's disease VPS35[D620N] mutation enhances LRRK2-mediated Rab protein phosphorylation in mouse and human.Isolated nigral degeneration without pathological protein aggregation in autopsied brains with LRRK2 p.R1441H homozygous and heterozygous mutations A pathway for Parkinson's Disease LRRK2 kinase to block primary cilia and Sonic hedgehog signaling in the brain LRRK2 and its substrate Rab GTPases are sequentially targeted onto stressed lysosomes and maintain their homeostasis

P2860

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P2860

Rab29 activation of the Parkinson's disease-associated LRRK2 kinase.

http://www.wikidata.org/entity/Q47150726

description

2017 nî lūn-bûn

@nan

2017年の論文

@ja

2017年学术文章

@wuu

2017年学术文章

@zh

2017年学术文章

@zh-cn

2017年学术文章

@zh-hans

2017年学术文章

@zh-my

2017年学术文章

@zh-sg

2017年學術文章

@yue

2017年學術文章

@zh-hant

name

Rab29 activation of the Parkinson's disease-associated LRRK2 kinase.

@en

Rab29 activation of the Parkinson's disease-associated LRRK2 kinase.

@nl

type

label

Rab29 activation of the Parkinson's disease-associated LRRK2 kinase.

@en

Rab29 activation of the Parkinson's disease-associated LRRK2 kinase.

@nl

prefLabel

Rab29 activation of the Parkinson's disease-associated LRRK2 kinase.

@en

Rab29 activation of the Parkinson's disease-associated LRRK2 kinase.

@nl

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P1433

The EMBO Journal

P1476

Rab29 activation of the Parkinson's disease-associated LRRK2 kinase.

@en

P2093

Melanie Wightman

http://www.w3.org/2001/XMLSchema#string

Rachel Gomez

http://www.w3.org/2001/XMLSchema#string

Terina N Martinez

http://www.w3.org/2001/XMLSchema#string

P2860

GTP binding is essential to the protein kinase activity of LRRK2, a causative gene product for familial Parkinson's disease

A role of Rab29 in the integrity of the trans-Golgi network and retrograde trafficking of mannose-6-phosphate receptor

VARP is recruited on to endosomes by direct interaction with retromer, where together they function in export to the cell surface

The R1441C mutation of LRRK2 disrupts GTP hydrolysis

Kinase activity of mutant LRRK2 mediates neuronal toxicity

LRRK2 transport is regulated by its novel interacting partner Rab32

Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant

Phosphorylation of LRRK2 by casein kinase 1α regulates trans-Golgi clustering via differential interaction with ARHGEF7

Parkinson-related LRRK2 mutation R1441C/G/H impairs PKA phosphorylation of LRRK2 and disrupts its interaction with 14-3-3

RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk

P304

1-18

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scholarly article

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10.15252/EMBJ.201798099

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1

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37

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Suzanne R Pfeffer

Herschel S Dhekne

Francesca Tonelli

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2017-12-06T00:00:00Z

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P698

29212815

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P921

Parkinson's disease

P932

5753036

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