Mechanism of dual specificity kinase activity of DYRK1A.
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DYRK1A, a Dosage-Sensitive Gene Involved in Neurodevelopmental Disorders, Is a Target for Drug Development in Down SyndromeThe structure of a dual-specificity tyrosine phosphorylation-regulated kinase 1A-PKC412 complex reveals disulfide-bridge formation with the anomalous catalytic loop HRD(HCD) cysteineThe adaptor protein DCAF7 mediates the interaction of the adenovirus E1A oncoprotein with the protein kinases DYRK1A and HIPK2Selectivity Profiling and Biological Activity of Novel β-Carbolines as Potent and Selective DYRK1 Kinase InhibitorsSelective inhibition of the kinase DYRK1A by targeting its folding processDYRK1A haploinsufficiency causes a new recognizable syndrome with microcephaly, intellectual disability, speech impairment, and distinct facies.A high-throughput chemical screen reveals that harmine-mediated inhibition of DYRK1A increases human pancreatic beta cell replication.Putative RNA-Directed Adaptive Mutations in Cancer Evolution.A dual specificity kinase, DYRK1A, as a potential therapeutic target for head and neck squamous cell carcinoma.DYRK1B mutations associated with metabolic syndrome impair the chaperone-dependent maturation of the kinase domain.Identification of DYRK1B as a substrate of ERK1/2 and characterisation of the kinase activity of DYRK1B mutants from cancer and metabolic syndrome.Effect of tyrosine autophosphorylation on catalytic activity and subcellular localisation of homeodomain-interacting protein kinases (HIPK).Ssp2 Binding Activates the Smk1 Mitogen-Activated Protein Kinase.Effects of Y361-auto-phosphorylation on structural plasticity of the HIPK2 kinase domain.Functional characterization of DYRK1A missense variants associated with a syndromic form of intellectual deficiency and autism.Emerging Roles of DYRK Kinases in Embryogenesis and Hedgehog Pathway Control.Mutational analysis of two residues in the DYRK homology box of the protein kinase DYRK1A.Correction of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A
P2860
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P2860
Mechanism of dual specificity kinase activity of DYRK1A.
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2013 nî lūn-bûn
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2013年の論文
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Mechanism of dual specificity kinase activity of DYRK1A.
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Mechanism of dual specificity kinase activity of DYRK1A.
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type
label
Mechanism of dual specificity kinase activity of DYRK1A.
@en
Mechanism of dual specificity kinase activity of DYRK1A.
@nl
prefLabel
Mechanism of dual specificity kinase activity of DYRK1A.
@en
Mechanism of dual specificity kinase activity of DYRK1A.
@nl
P2093
P2860
P356
P1433
P1476
Mechanism of dual specificity kinase activity of DYRK1A.
@en
P2093
Agnes Walte
Christian Preisinger
Franz Bracher
Katharina Rüben
Nikolaus Hilz
Simone Bamberg-Lemper
P2860
P304
P356
10.1111/FEBS.12411
P407
P577
2013-07-22T00:00:00Z