Constitutive phosphorylation of MDC1 physically links the MRE11-RAD50-NBS1 complex to damaged chromatin. - Test2 - elhamkhani - TriplyDB

Constitutive phosphorylation of MDC1 physically links the MRE11-RAD50-NBS1 complex to damaged chromatin.

Constitutive phosphorylation of MDC1 physically links the MRE11-RAD50-NBS1 complex to damaged chromatin.

http://www.wikidata.org/entity/Q36562899

about

Nijmegen breakage syndrome (NBS)CK2 phosphorylation-dependent interaction between aprataxin and MDC1 in the DNA damage response A divalent FHA/BRCT-binding mechanism couples the MRE11-RAD50-NBS1 complex to damaged chromatin A supramodular FHA/BRCT-repeat architecture mediates Nbs1 adaptor function in response to DNA damage Rad17 recruits the MRE11-RAD50-NBS1 complex to regulate the cellular response to DNA double-strand breaks Dynamics of DNA damage response proteins at DNA breaks: a focus on protein modifications BRCT domains: easy as one, two, three Ubc13: the Lys63 ubiquitin chain building machine The Knowns Unknowns: Exploring the Homologous Recombination Repair Pathway in Toxoplasma gondii A Novel Aspect of Tumorigenesis-BMI1 Functions in Regulating DNA Damage Response Targeting ATM-deficient CLL through interference with DNA repair pathways The Mre11/Rad50/Nbs1 complex: recent insights into catalytic activities and ATP-driven conformational changes Structure of a Second BRCT Domain Identified in the Nijmegen Breakage Syndrome Protein Nbs1 and its Function in an MDC1-Dependent Localization of Nbs1 to DNA Damage Sites Nbs1 Flexibly Tethers Ctp1 and Mre11-Rad50 to Coordinate DNA Double-Strand Break Processing and Repair Structural mechanism of the phosphorylation-dependent dimerization of the MDC1 forkhead-associated domain The molecular basis of ATM-dependent dimerization of the Mdc1 DNA damage checkpoint mediator Dimerization, but not phosphothreonine binding, is conserved between the forkhead-associated domains of Drosophila MU2 and human MDC1 Structural Insights into Recognition of MDC1 by TopBP1 in DNA Replication Checkpoint Control The DNA Damage Response: Making It Safe to Play with Knives Envisioning the dynamics and flexibility of Mre11-Rad50-Nbs1 complex to decipher its roles in DNA replication and repair Ancient and recent adaptive evolution of primate non-homologous end joining genes Giraffe genome sequence reveals clues to its unique morphology and physiology.Recruitment of RNA polymerase II cofactor PC4 to DNA damage sites And-1 is required for homologous recombination repair by regulating DNA end resection.MRE11-RAD50-NBS1 complex dictates DNA repair independent of H2AX.Autophosphorylation at serine 1981 stabilizes ATM at DNA damage sites.Mediator of DNA damage checkpoint 1 (MDC1) contributes to high NaCl-induced activation of the osmoprotective transcription factor TonEBP/OREBP.A fine-scale dissection of the DNA double-strand break repair machinery and its implications for breast cancer therapy.ATM increases activation-induced cytidine deaminase activity at downstream S regions during class-switch recombination.BCR-ABL stimulates mutagenic homologous DNA double-strand break repair via the DNA-end-processing factor CtIP.H2AX phosphorylation screen of cells from radiosensitive cancer patients reveals a novel DNA double-strand break repair cellular phenotype.Genomic instability, defective spermatogenesis, immunodeficiency, and cancer in a mouse model of the RIDDLE syndrome DNA damage in Nijmegen Breakage Syndrome cells leads to PARP hyperactivation and increased oxidative stress.Protein kinase CK2 localizes to sites of DNA double-strand break regulating the cellular response to DNA damage The p400 ATPase regulates nucleosome stability and chromatin ubiquitination during DNA repair.The viral oncoprotein tax sequesters DNA damage response factors by tethering MDC1 to chromatin.The RING finger protein RNF8 ubiquitinates Nbs1 to promote DNA double-strand break repair by homologous recombination.Time to bloom.DNA double-strand break signaling and human disorders.Mre11-Rad50-Nbs1 conformations and the control of sensing, signaling, and effector responses at DNA double-strand breaks

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P2860

Constitutive phosphorylation of MDC1 physically links the MRE11-RAD50-NBS1 complex to damaged chromatin.

http://www.wikidata.org/entity/Q36562899

description

2008 nî lūn-bûn

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2008年論文

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2008年論文

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Constitutive phosphorylation o ...... complex to damaged chromatin.

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Constitutive phosphorylation o ...... complex to damaged chromatin.

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Constitutive phosphorylation o ...... complex to damaged chromatin.

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Christoph Spycher

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Edward S Miller

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Kelly Townsend

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Lucijana Pavic

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Manuel Stucki

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Nicholas A Morrice

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Pavel Janscak

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P2860

MDC1 is a mediator of the mammalian DNA damage checkpoint

ATM activation by DNA double-strand breaks through the Mre11-Rad50-Nbs1 complex

MDC1 directly binds phosphorylated histone H2AX to regulate cellular responses to DNA double-strand breaks

Large-scale characterization of HeLa cell nuclear phosphoproteins

ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage

NBS1 localizes to gamma-H2AX foci through interaction with the FHA/BRCT domain

Xrcc4 physically links DNA end processing by polynucleotide kinase to DNA ligation by DNA ligase IV

Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention

hMre11 and hRad50 nuclear foci are induced during the normal cellular response to DNA double-strand breaks

Mre11 assembles linear DNA fragments into DNA damage signaling complexes

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10.1083/JCB.200709008

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2

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181

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Grant S Stewart

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5442010

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18411308

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phosphorylation

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2315671

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