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Substrate-mediated electron transfer in peptidylglycine alpha-hydroxylating monooxygenaseStudies ofToxoplasma gondiiandPlasmodium falciparumenoyl acyl carrier protein reductase and implications for the development of antiparasitic agentsType I and type II fatty acid biosynthesis in Eimeria tenella: enoyl reductase activity and structurePlasmodium falciparumacyl carrier protein crystal structures in disulfide-linked and reduced states and their prevalence during blood stage growthIdentification and Development of Novel Inhibitors of Toxoplasma gondii Enoyl ReductaseDifferential Reactivity between Two Copper Sites in Peptidylglycine α-Hydroxylating MonooxygenaseThe benzimidazole based drugs show good activity against T. gondii but poor activity against its proposed enoyl reductase enzyme targetAmidation of bioactive peptides: the structure of peptidylglycine alpha-hydroxylating monooxygenaseScavenging of the cofactor lipoate is essential for the survival of the malaria parasite Plasmodium falciparumRedox-dependent lipoylation of mitochondrial proteins in Plasmodium falciparumThe suf iron-sulfur cluster synthesis pathway is required for apicoplast maintenance in malaria parasitesFunctional characterization of the acyl carrier protein (PfACP) and beta-ketoacyl ACP synthase III (PfKASIII) from Plasmodium falciparumDelivery of antimicrobials into parasitesThe amidase domain of lipoamidase specifically inactivates lipoylated proteins in vivo.Targeting the fatty acid biosynthesis enzyme, beta-ketoacyl-acyl carrier protein synthase III (PfKASIII), in the identification of novel antimalarial agents.Maternal inheritance and stage-specific variation of the apicoplast in Toxoplasma gondii during development in the intermediate and definitive host.Lipoic acid metabolism in microbial pathogens.Targeting the Lipid Metabolic Pathways for the Treatment of Malaria.The catalytic copper of peptidylglycine alpha-hydroxylating monooxygenase also plays a critical structural roleIncreased prevalence of the pfdhfr/phdhps quintuple mutant and rapid emergence of pfdhps resistance mutations at codons 581 and 613 in Kisumu, Kenya.Parasites FeS up: iron-sulfur cluster biogenesis in eukaryotic pathogens.Detection of pathogen-specific antibodies by loop-mediated isothermal amplification.Novel N-benzoyl-2-hydroxybenzamide disrupts unique parasite secretory pathway.Fatty Acid synthesis as a target for antimalarial drug discovery.Rational inhibitor design and iterative screening in the identification of selective plasmodial cyclin dependent kinase inhibitors.Targeting malaria with specific CDK inhibitors.Expression, purification and preliminary crystallographic analysis of the Toxoplasma gondii enoyl reductase.Plasmodium falciparum apicoplast transit peptides are unstructured in vitro and during apicoplast import.Novel type II fatty acid biosynthesis (FAS II) inhibitors as multistage antimalarial agentsA key role for lipoic acid synthesis during Plasmodium liver stage developmentModification of triclosan scaffold in search of improved inhibitors for enoyl-acyl carrier protein (ACP) reductase in Toxoplasma gondii.Relation between positional specificity and chirality in mammalian lipoxygenases.Discrimination of potent inhibitors of Toxoplasma gondii enoyl-acyl carrier protein reductase by a thermal shift assay.Development of a triclosan scaffold which allows for adaptations on both the A- and B-ring for transport peptides.Design, synthesis, and biological activity of diaryl ether inhibitors of Toxoplasma gondii enoyl reductase.Lactococcus lactis fabH, encoding beta-ketoacyl-acyl carrier protein synthase, can be functionally replaced by the Plasmodium falciparum congener.Structure and mechanism of lipoxygenases.Isoflavone dimers and other bioactive constituents from the figs of Ficus mucuso.Ceramide and Cerebroside from the stem bark of Ficus mucuso (Moraceae).A novel lipoate attachment enzyme is shared by Plasmodium and Chlamydia species.
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Sean T Prigge
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