Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis - Wikidata - thesis-toulmin - TriplyDB

Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis

Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis

http://www.wikidata.org/entity/Q24676117

about

The notch ligand JAGGED1 as a target for anti-tumor therapy Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin.Identification and selected reaction monitoring (SRM) quantification of endocytosis factors associated with Numb Increased Wnt signaling triggers oncogenic conversion of human breast epithelial cells by a Notch-dependent mechanism The prolyl-isomerase Pin1 is a Notch1 target that enhances Notch1 activation in cancer Direct inhibition of the NOTCH transcription factor complex Regulation of myeloid leukaemia by the cell-fate determinant Musashi Notch1 is a p53 target gene involved in human keratinocyte tumor suppression through negative regulation of ROCK1/2 and MRCKalpha kinases A Role for Notch Signalling in Breast Cancer and Endocrine Resistance Cancer stem cells and signaling pathways in radioresistance Targeting the Notch signaling pathway in cancer therapeutics From fly wings to targeted cancer therapies: a centennial for notch signaling Wound healing and cancer stem cells: inflammation as a driver of treatment resistance in breast cancer The Numb/p53 circuitry couples replicative self-renewal and tumor suppression in mammary epithelial cells.Alterations of the Notch pathway in lung cancer.NOTCH receptors in gastric and other gastrointestinal cancers: oncogenes or tumor suppressors?Asymmetric cell division of stem and progenitor cells during homeostasis and cancer Sustained proliferation in cancer: Mechanisms and novel therapeutic targets Automated selection of regions of interest for intensity-based FRET analysis of transferrin endocytic trafficking in normal vs. cancer cells Loss of the Par3 polarity protein promotes breast tumorigenesis and metastasis.Dose-dependent induction of distinct phenotypic responses to Notch pathway activation in mammary epithelial cells Global profiling and molecular characterization of alternative splicing events misregulated in lung cancer.Lis1 regulates asymmetric division in hematopoietic stem cells and in leukemia Decoding breast cancer tissue-stroma interactions using species-specific sequencing miR-146a enhances the oncogenicity of oral carcinoma by concomitant targeting of the IRAK1, TRAF6 and NUMB genes.Notch signaling through tramtrack bypasses the mitosis promoting activity of the JNK pathway in the mitotic-to-endocycle transition of Drosophila follicle cells.Characterization of Notch1 antibodies that inhibit signaling of both normal and mutated Notch1 receptors.Cooperation of Notch and Ras/MAPK signaling pathways in human breast carcinogenesis Breast cancer cells produce tenascin C as a metastatic niche component to colonize the lungs Pre-clinical validation of a selective anti-cancer stem cell therapy for Numb-deficient human breast cancers.Hypoxia potentiates Notch signaling in breast cancer leading to decreased E-cadherin expression and increased cell migration and invasion Stress-induced switch in Numb isoforms enhances Notch-dependent expression of subtype-specific transient receptor potential channel.Functional identification of tumor-suppressor genes through an in vivo RNA interference screen in a mouse lymphoma model Mammary development and breast cancer: the role of stem cells Cross-talk between miRNA and Notch signaling pathways in tumor development and progression.MicroRNAs profiling in murine models of acute and chronic asthma: a relationship with mRNAs targets.NOTCH pathway blockade depletes CD133-positive glioblastoma cells and inhibits growth of tumor neurospheres and xenografts Dickkopf1 regulates fate decision and drives breast cancer stem cells to differentiation: an experimentally supported mathematical model Two novel human NUMB isoforms provide a potential link between development and cancer.SEL1L a multifaceted protein playing a role in tumor progression.

P2860

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P2860

Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis

http://www.wikidata.org/entity/Q24676117

description

2004 nî lūn-bûn

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2004 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2004 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2004年の論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年論文

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2004年论文

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name

Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis

@ast

Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis

@en

Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis

@nl

type

label

Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis

@ast

Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis

@en

Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis

@nl

prefLabel

Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis

@ast

Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis

@en

Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis

@nl

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P356

P1433

Journal of Cell Biology

P1476

Loss of negative regulation by Numb over Notch is relevant to human breast carcinogenesis

@en

P2093

Elisa Santolini

http://www.w3.org/2001/XMLSchema#string

Esther Hulleman

http://www.w3.org/2001/XMLSchema#string

Maria Capra

http://www.w3.org/2001/XMLSchema#string

Michela Serresi

http://www.w3.org/2001/XMLSchema#string

Salvatore Pece

http://www.w3.org/2001/XMLSchema#string

Stefano Zurrida

http://www.w3.org/2001/XMLSchema#string

P2860

TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms

The Mdm2 oncoprotein interacts with the cell fate regulator Numb

LNX functions as a RING type E3 ubiquitin ligase that targets the cell fate determinant Numb for ubiquitin-dependent degradation

Siah-1 binds and regulates the function of Numb

Numb is an endocytic protein

Mechanisms underlying ubiquitination

Notch signaling: cell fate control and signal integration in development

Notch signaling: from the outside in

Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain

Control of daughter cell fates during asymmetric division: interaction of Numb and Notch

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215-21

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scholarly article

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756980

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10.1083/JCB.200406140

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P433

2

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167

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Pier Paolo Di Fiore

Viviana Galimberti

Patrick Maisonneuve

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2004-10-25T00:00:00Z

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8225092

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15492044

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2172557

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