Cleavage of stalled forks by fission yeast Mus81/Eme1 in absence of DNA replication checkpoint
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Managing Single-Stranded DNA during Replication Stress in Fission YeastRescuing stalled or damaged replication forksReplication stress in early S phase generates apparent micronuclei and chromosome rearrangement in fission yeast.Rad53-Mediated Regulation of Rrm3 and Pif1 DNA Helicases Contributes to Prevention of Aberrant Fork Transitions under Replication Stress.Complex chromosomal rearrangements mediated by break-induced replication involve structure-selective endonucleases.Srs2 promotes Mus81-Mms4-mediated resolution of recombination intermediates.The cancer therapeutic potential of Chk1 inhibitors: how mechanistic studies impact on clinical trial designFission yeast Rad52 phosphorylation restrains error prone recombination pathwaysThe Mus81-Mms4 structure-selective endonuclease requires nicked DNA junctions to undergo conformational changes and bend its DNA substrates for cleavage.The extent of error-prone replication restart by homologous recombination is controlled by Exo1 and checkpoint proteins.Redundant mechanisms prevent mitotic entry following replication arrest in the absence of Cdc25 hyper-phosphorylation in fission yeast.Regulation of homologous recombination in eukaryotes.Structure-specific DNA endonuclease Mus81/Eme1 generates DNA damage caused by Chk1 inactivation.Processing of joint molecule intermediates by structure-selective endonucleases during homologous recombination in eukaryotes.Histone H3K56 acetylation, CAF1, and Rtt106 coordinate nucleosome assembly and stability of advancing replication forksHydroxyurea-stalled replication forks become progressively inactivated and require two different RAD51-mediated pathways for restart and repair.Continued DNA synthesis in replication checkpoint mutants leads to fork collapse.Recovery of arrested replication forks by homologous recombination is error-prone.Survival of the replication checkpoint deficient cells requires MUS81-RAD52 function.Targeting lung cancer through inhibition of checkpoint kinases.Mus81-mediated DNA cleavage resolves replication forks stalled by topoisomerase I-DNA complexes.Replication fork stalling in WRN-deficient cells is overcome by prompt activation of a MUS81-dependent pathway.Stwl modifies chromatin compaction and is required to maintain DNA integrity in the presence of perturbed DNA replication.A junction branch point adjacent to a DNA backbone nick directs substrate cleavage by Saccharomyces cerevisiae Mus81-Mms4.RNF4 and PLK1 are required for replication fork collapse in ATR-deficient cellsNucleolytic processing of aberrant replication intermediates by an Exo1-Dna2-Sae2 axis counteracts fork collapse-driven chromosome instability.The S-phase checkpoint: targeting the replication fork.The Intra-S Checkpoint Responses to DNA Damage.Regulation of Mus81-Eme1 Holliday junction resolvase in response to DNA damage.Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication.Resolving branched DNA intermediates with structure-specific nucleases during replication in eukaryotes.Homologous recombination as a replication fork escort: fork-protection and recovery.Replication fork reversal in eukaryotes: from dead end to dynamic response.Recombinational DNA repair is regulated by compartmentalization of DNA lesions at the nuclear pore complex.Mus81 knockdown improves chemosensitivity of hepatocellular carcinoma cells by inducing S-phase arrest and promoting apoptosis through CHK1 pathwayS-phase checkpoint regulations that preserve replication and chromosome integrity upon dNTP depletion.Premature Cdk1/Cdc5/Mus81 pathway activation induces aberrant replication and deleterious crossoverCleavage of a model DNA replication fork by a Type I restriction endonuclease.Temporal regulation of the Mus81-Mms4 endonuclease ensures cell survival under conditions of DNA damage.Localization of Smc5/6 to centromeres and telomeres requires heterochromatin and SUMO, respectively.
P2860
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P2860
Cleavage of stalled forks by fission yeast Mus81/Eme1 in absence of DNA replication checkpoint
description
2007 nî lūn-bûn
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2007年の論文
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2007年学术文章
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2007年学术文章
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2007年学术文章
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name
Cleavage of stalled forks by f ...... of DNA replication checkpoint
@ast
Cleavage of stalled forks by f ...... of DNA replication checkpoint
@en
type
label
Cleavage of stalled forks by f ...... of DNA replication checkpoint
@ast
Cleavage of stalled forks by f ...... of DNA replication checkpoint
@en
prefLabel
Cleavage of stalled forks by f ...... of DNA replication checkpoint
@ast
Cleavage of stalled forks by f ...... of DNA replication checkpoint
@en
P2093
P2860
P356
P1476
Cleavage of stalled forks by f ...... of DNA replication checkpoint
@en
P2093
Benoît Froget
Giuseppe Baldacci
Joël Blaisonneau
P2860
P304
P356
10.1091/MBC.E07-07-0728
P577
2007-11-21T00:00:00Z