Distinct roles in vivo for the ubiquitin-proteasome system and the autophagy-lysosomal pathway in the degradation of α-synuclein.
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Identification of novel ATP13A2 interactors and their role in α-synuclein misfolding and toxicityDisrupted autophagy leads to dopaminergic axon and dendrite degeneration and promotes presynaptic accumulation of α-synuclein and LRRK2 in the brainNeuronal response in Alzheimer's and Parkinson's disease: the effect of toxic proteins on intracellular pathwaysChaperones in NeurodegenerationDeconvoluting the complexity of autophagy and Parkinson's disease for potential therapeutic purposeMolecular chaperones and co-chaperones in Parkinson diseaseGlia and alpha-synuclein in neurodegeneration: A complex interactionProtein degradation pathways in Parkinson's disease: curse or blessingPhosphorylation modulates clearance of alpha-synuclein inclusions in a yeast model of Parkinson's diseaseDysregulation of autophagy and mitochondrial function in Parkinson's diseaseAlpha-Synuclein in Parkinson's Disease: From Pathogenetic Dysfunction to Potential Clinical ApplicationAutophagy in neurodegenerative diseases: from mechanism to therapeutic approachLegal but lethal: functional protein aggregation at the verge of toxicityThe phosphorylation of α-synuclein: development and implication for the mechanism and therapy of the Parkinson's diseaseReducing synuclein accumulation improves neuronal survival after spinal cord injuryChronic treatment with novel small molecule Hsp90 inhibitors rescues striatal dopamine levels but not α-synuclein-induced neuronal cell lossGenetic and chemical activation of TFEB mediates clearance of aggregated α-synucleinGeneration of SNCA Cell Models Using Zinc Finger Nuclease (ZFN) Technology for Efficient High-Throughput Drug ScreeningPale body-like inclusion formation and neurodegeneration following depletion of 26S proteasomes in mouse brain neurones are independent of α-synucleinSystemic proteasome inhibition triggers neurodegeneration in a transgenic mouse model expressing human α-synuclein under oligodendrocyte promoter: implications for multiple system atrophy.Glial A30P alpha-synuclein pathology segregates neurogenesis from anxiety-related behavior in conditional transgenic mice.Nigral proteasome inhibition in mice leads to motor and non-motor deficits and increased expression of Ser129 phosphorylated α-synucleinMolecular chaperones and protein folding as therapeutic targets in Parkinson's disease and other synucleinopathiesp62/SQSTM1-dependent autophagy of Lewy body-like α-synuclein inclusionsExpression and cellular distribution of ubiquitin in response to injury in the developing spinal cord of Monodelphis domestica.ATP6V0C knockdown in neuroblastoma cells alters autophagy-lysosome pathway function and metabolism of proteins that accumulate in neurodegenerative disease.Saturated fatty acids modulate autophagy's proteins in the hypothalamusα-Synuclein-independent histopathological and motor deficits in mice lacking the endolysosomal Parkinsonism protein Atp13a2.New roles of glycosaminoglycans in α-synuclein aggregation in a cellular model of Parkinson disease.Mutant alpha-synuclein causes age-dependent neuropathology in monkey brainCurcumin Treatment Improves Motor Behavior in α-Synuclein Transgenic MiceMolecular chaperones in Parkinson's disease--present and futureOverexpression of alpha-synuclein at non-toxic levels increases dopaminergic cell death induced by copper exposure via modulation of protein degradation pathways.Interaction between Neuromelanin and Alpha-Synuclein in Parkinson's Disease.Alpha-synuclein's degradation in vivo: opening a new (cranial) window on the roles of degradation pathways in Parkinson disease.Alpha-synuclein aggregation involves a bafilomycin A 1-sensitive autophagy pathway.Mannose 6-Phosphate Receptor Is Reduced in -Synuclein Overexpressing Models of Parkinsons Disease.α-Synuclein and nonhuman primate models of Parkinson's diseaseAlpha-Synuclein affects neurite morphology, autophagy, vesicle transport and axonal degeneration in CNS neurons.A Novel Hsp90 Inhibitor Activates Compensatory Heat Shock Protein Responses and Autophagy and Alleviates Mutant A53T α-Synuclein Toxicity.
P2860
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P2860
Distinct roles in vivo for the ubiquitin-proteasome system and the autophagy-lysosomal pathway in the degradation of α-synuclein.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Distinct roles in vivo for the ...... he degradation of α-synuclein.
@ast
Distinct roles in vivo for the ...... he degradation of α-synuclein.
@en
type
label
Distinct roles in vivo for the ...... he degradation of α-synuclein.
@ast
Distinct roles in vivo for the ...... he degradation of α-synuclein.
@en
prefLabel
Distinct roles in vivo for the ...... he degradation of α-synuclein.
@ast
Distinct roles in vivo for the ...... he degradation of α-synuclein.
@en
P2093
P2860
P50
P921
P1476
Distinct roles in vivo for the ...... he degradation of α-synuclein.
@en
P2093
Darius Ebrahimi-Fakhari
Ippolita Cantuti-Castelvetri
Pamela J McLean
Vivek K Unni
Zhanyun Fan
P2860
P304
14508-14520
P356
10.1523/JNEUROSCI.1560-11.2011
P407
P577
2011-10-01T00:00:00Z