V(D)J recombinase binding and cleavage of cryptic recombination signal sequences identified from lymphoid malignancies.
about
Snaps and mends: DNA breaks and chromosomal translocationsHMGB1/2 can target DNA for illegitimate cleavage by the RAG1/2 complex.Non-consensus heptamer sequences destabilize the RAG post-cleavage complex, making ends available to alternative DNA repair pathways.Synapsis alters RAG-mediated nicking at Tcrb recombination signal sequences: implications for the “beyond 12/23” ruleRSSsite: a reference database and prediction tool for the identification of cryptic Recombination Signal Sequences in human and murine genomes.The DSIF subunits Spt4 and Spt5 have distinct roles at various phases of immunoglobulin class switch recombinationIllegitimate V(D)J recombination involving nonantigen receptor loci in lymphoid malignancy.Histone reader BRWD1 targets and restricts recombination to the Igk locus.Recruitment of RAG1 and RAG2 to Chromatinized DNA during V(D)J Recombination.Two Mutually Exclusive Local Chromatin States Drive Efficient V(D)J RecombinationAn activation-induced cytidine deaminase-independent mechanism of secondary VH gene rearrangement in preimmune human B cellsSequence and structural basis for chromosomal fragility during translocations in cancer.Role of recombination activating genes in the generation of antigen receptor diversity and beyond.Domesticated transposable element gene products in human cancer.A non-B DNA can replace heptamer of V(D)J recombination when present along with a nonamer: implications in chromosomal translocations and cancer.RAG-mediated recombination is the predominant driver of oncogenic rearrangement in ETV6-RUNX1 acute lymphoblastic leukemia.ETV6-RUNX1 + Acute Lymphoblastic Leukaemia in Identical Twins.Mechanism of ETV6-RUNX1 Leukemia.Complex oncogenic translocations with gene amplification are initiated by specific DNA breaks in lymphocytes.Mechanistic basis for RAG discrimination between recombination sites and the off-target sites of human lymphomas.HIV Tat induces a prolonged MYC relocalization next to IGH in circulating B-cells.Characterization of chromosomal translocation breakpoint sequences in solid tumours: "an in silico analysis".RAG Recombinase as a Selective Pressure for Genome EvolutionHuman chromosomal translocations at CpG sites and a theoretical basis for their lineage and stage specificity.H3K4me3 stimulates the V(D)J RAG complex for both nicking and hairpinning in trans in addition to tethering in cis: implications for translocations.G-quadruplex structures formed at the HOX11 breakpoint region contribute to its fragility during t(10;14) translocation in T-cell leukemia.Biochemical Characterization of Nonamer Binding Domain of RAG1 Reveals its Thymine Preference with Respect to Length and Position.Significant Role of Segmental Duplications and SIDD Sites in Chromosomal Translocations of Hematological Malignancies: A Multi-parametric Bioinformatic Analysis.
P2860
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P2860
V(D)J recombinase binding and cleavage of cryptic recombination signal sequences identified from lymphoid malignancies.
description
2008 nî lūn-bûn
@nan
2008年の論文
@ja
2008年学术文章
@wuu
2008年学术文章
@zh-cn
2008年学术文章
@zh-hans
2008年学术文章
@zh-my
2008年学术文章
@zh-sg
2008年學術文章
@yue
2008年學術文章
@zh
2008年學術文章
@zh-hant
name
V(D)J recombinase binding and ...... ed from lymphoid malignancies.
@en
type
label
V(D)J recombinase binding and ...... ed from lymphoid malignancies.
@en
prefLabel
V(D)J recombinase binding and ...... ed from lymphoid malignancies.
@en
P2860
P356
P1476
V(D)J recombinase binding and ...... ed from lymphoid malignancies.
@en
P2093
Ming Zhang
Patrick C Swanson
P2860
P304
P356
10.1074/JBC.M710301200
P407
P577
2008-01-09T00:00:00Z