SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway
about
SMG6 interacts with the exon junction complex via two conserved EJC-binding motifs (EBMs) required for nonsense-mediated mRNA decayBinding of a novel SMG-1-Upf1-eRF1-eRF3 complex (SURF) to the exon junction complex triggers Upf1 phosphorylation and nonsense-mediated mRNA decaySMG6 is the catalytic endonuclease that cleaves mRNAs containing nonsense codons in metazoanAn unusual arrangement of two 14-3-3-like domains in the SMG5-SMG7 heterodimer is required for efficient nonsense-mediated mRNA decayInteractions between UPF1, eRFs, PABP and the exon junction complex suggest an integrated model for mammalian NMD pathwaysUpf1 ATPase-dependent mRNP disassembly is required for completion of nonsense- mediated mRNA decayA new MIF4G domain-containing protein, CTIF, directs nuclear cap-binding protein CBP80/20-dependent translationHuman UPF1 interacts with TPP1 and telomerase and sustains telomere leading-strand replicationUnusual bipartite mode of interaction between the nonsense-mediated decay factors, UPF1 and UPF2A crucial role for GW182 and the DCP1:DCP2 decapping complex in miRNA-mediated gene silencing.Functional analysis of the single Est1/Ebs1 homologue in Kluyveromyces lactis reveals roles in both telomere maintenance and rapamycin resistanceStructures of the PIN domains of SMG6 and SMG5 reveal a nuclease within the mRNA surveillance complexRNA granulesNonsense-mediated mRNA decay: novel mechanistic insights and biological impactThe dharma of nonsense-mediated mRNA decay in mammalian cellsNonsense-mediated mRNA decay: inter-individual variability and human diseaseStructural and functional analysis of the three MIF4G domains of nonsense-mediated decay factor UPF2Phospho-dependent and phospho-independent interactions of the helicase UPF1 with the NMD factors SMG5–SMG7 and SMG6Saccharomyces cerevisiae Ebs1p is a putative ortholog of human Smg7 and promotes nonsense-mediated mRNA decay.Targeting of aberrant mRNAs to cytoplasmic processing bodies.Nonsense-Mediated mRNA Decay: Degradation of Defective Transcripts Is Only Part of the StoryProtein RNA and protein protein interactions mediate association of human EST1A/SMG6 with telomeraseOrganizing principles of mammalian nonsense-mediated mRNA decayHow and where are nonsense mRNAs degraded in mammalian cells?Whole-genome sequencing in an autism multiplex familyThe TPR-containing domain within Est1 homologs exhibits species-specific roles in telomerase interaction and telomere length homeostasisMutations in genes involved in nonsense mediated decay ameliorate the phenotype of sel-12 mutants with amber stop mutations in Caenorhabditis elegansIdentification and characterization of small molecules that inhibit nonsense-mediated RNA decay and suppress nonsense p53 mutationsNonsense-mediated RNA decay regulation by cellular stress: implications for tumorigenesis.Current knowledge of MicroRNAs and noncoding RNAs in virus-infected cells.Emergence of a complex relationship between HIV-1 and the microRNA pathway.The mRNP remodeling mediated by UPF1 promotes rapid degradation of replication-dependent histone mRNA.A novel phosphorylation-independent interaction between SMG6 and UPF1 is essential for human NMD.When a ribosome encounters a premature termination codon.A role for nonsense-mediated mRNA decay in plants: pathogen responses are induced in Arabidopsis thaliana NMD mutants.Regulated assembly and disassembly of the yeast telomerase quaternary complex.A post-translational regulatory switch on UPF1 controls targeted mRNA degradationNonsense-mediated mRNA decay factors act in concert to regulate common mRNA targets.Antiviral protein APOBEC3G localizes to ribonucleoprotein complexes found in P bodies and stress granulesIdentification of SMG6 cleavage sites and a preferred RNA cleavage motif by global analysis of endogenous NMD targets in human cells.
P2860
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P2860
SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway
description
2005 nî lūn-bûn
@nan
2005 թուականի Փետրուարին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի փետրվարին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway
@ast
SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway
@en
SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway
@en-gb
SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway
@nl
type
label
SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway
@ast
SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway
@en
SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway
@en-gb
SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway
@nl
prefLabel
SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway
@ast
SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway
@en
SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway
@en-gb
SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway
@nl
P2093
P50
P921
P3181
P1433
P1476
SMG7 is a 14-3-3-like adaptor in the nonsense-mediated mRNA decay pathway
@en
P2093
Doris Lindner
Judith Ebert
Noemi Fukuhara
P304
P3181
P356
10.1016/J.MOLCEL.2005.01.010
P407
P577
2005-02-18T00:00:00Z