How and where are nonsense mRNAs degraded in mammalian cells?
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The RNA-binding E3 ubiquitin ligase MEX-3C links ubiquitination with MHC-I mRNA degradationHuman CWC22 escorts the helicase eIF4AIII to spliceosomes and promotes exon junction complex assemblyUpf1 ATPase-dependent mRNP disassembly is required for completion of nonsense- mediated mRNA decayNonsense-mediated mRNA decay: novel mechanistic insights and biological impactThe role of mammalian poly(A)-binding proteins in co-ordinating mRNA turnoverThe dharma of nonsense-mediated mRNA decay in mammalian cellsOrganizing principles of mammalian nonsense-mediated mRNA decayUnspliced precursors of NMD-sensitive β-globin transcripts exhibit decreased steady-state levels in erythroid cellsPlant nonsense-mediated mRNA decay is controlled by different autoregulatory circuits and can be induced by an EJC-like complex.Identification of SMG6 cleavage sites and a preferred RNA cleavage motif by global analysis of endogenous NMD targets in human cells.RNA surveillance is required for endoplasmic reticulum homeostasis.The human T-lymphotropic virus type 1 tax protein inhibits nonsense-mediated mRNA decay by interacting with INT6/EIF3E and UPF1.Temporal and spatial characterization of nonsense-mediated mRNA decay.Comparison of EJC-enhanced and EJC-independent NMD in human cells reveals two partially redundant degradation pathwaysTranscriptome-wide identification of NMD-targeted human mRNAs reveals extensive redundancy between SMG6- and SMG7-mediated degradation pathways.Molecular signal networks and regulating mechanisms of the unfolded protein response.NMD: a multifaceted response to premature translational termination.Plant serine/arginine-rich proteins: roles in precursor messenger RNA splicing, plant development, and stress responses.The 5' → 3' exoribonuclease XRN1/Pacman and its functions in cellular processes and development.Mechanism of the initiation of mRNA decay: role of eRF3 family G proteins.A novel post-transcriptional role for ubiquitin in the differential regulation of MHC class I allotypes.Structural and functional control of the eukaryotic mRNA decapping machinery.Regulation of natural mRNAs by the nonsense-mediated mRNA decay pathway.Molecular mechanisms in DM1 - a focus on foci.RNP transport in cell biology: the long and winding road.DbpA is a region-specific RNA helicase.Interaction between quality control systems for ER protein folding and RNA biogenesis.Nuclease escape elements protect messenger RNA against cleavage by multiple viral endonucleases.Premature termination codon readthrough in human cells occurs in novel cytoplasmic foci and requires UPF proteins.Interaction of PABPC1 with the translation initiation complex is critical to the NMD resistance of AUG-proximal nonsense mutations.UPF1 association with the cap-binding protein, CBP80, promotes nonsense-mediated mRNA decay at two distinct steps.The SMG5-SMG7 heterodimer directly recruits the CCR4-NOT deadenylase complex to mRNAs containing nonsense codons via interaction with POP2.Upf proteins: highly conserved factors involved in nonsense mRNA mediated decay.Transcript-specific characteristics determine the contribution of endo- and exonucleolytic decay pathways during the degradation of nonsense-mediated decay substrates.p-4S-UPF1 recruits SMG5; SMG7; SMG6; PNRC2; DCP1A; and PP2ADecay of mRNA in SMG6:SMG5:SMG7:mRNA complexLost in Translation: Ribosome-Associated mRNA and Protein Quality Controls
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P2860
How and where are nonsense mRNAs degraded in mammalian cells?
description
2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
artículu científicu espublizáu en 2010
@ast
im Januar 2010 veröffentlichter wissenschaftlicher Artikel
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scientific journal article
@en
vedecký článok (publikovaný 2010/01/01)
@sk
vědecký článek publikovaný v roce 2010
@cs
wetenschappelijk artikel (gepubliceerd op 2010/01/01)
@nl
наукова стаття, опублікована в січні 2010
@uk
مقالة علمية (نشرت عام 2010)
@ar
name
How and where are nonsense mRNAs degraded in mammalian cells?
@ast
How and where are nonsense mRNAs degraded in mammalian cells?
@en
How and where are nonsense mRNAs degraded in mammalian cells?
@nl
type
label
How and where are nonsense mRNAs degraded in mammalian cells?
@ast
How and where are nonsense mRNAs degraded in mammalian cells?
@en
How and where are nonsense mRNAs degraded in mammalian cells?
@nl
prefLabel
How and where are nonsense mRNAs degraded in mammalian cells?
@ast
How and where are nonsense mRNAs degraded in mammalian cells?
@en
How and where are nonsense mRNAs degraded in mammalian cells?
@nl
P2860
P356
P1433
P1476
How and where are nonsense mRNAs degraded in mammalian cells?
@en
P2860
P356
10.4161/RNA.7.1.10578
P577
2010-01-01T00:00:00Z