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Is the mammalian serine palmitoyltransferase a high-molecular-mass complex?

Is the mammalian serine palmitoyltransferase a high-molecular-mass complex?

http://www.wikidata.org/entity/Q24298593

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Orm family proteins mediate sphingolipid homeostasis Mutations in the SPTLC2 subunit of serine palmitoyltransferase cause hereditary sensory and autonomic neuropathy type I The SPTLC3 subunit of serine palmitoyltransferase generates short chain sphingoid bases Identification of small subunits of mammalian serine palmitoyltransferase that confer distinct acyl-CoA substrate specificities The External Aldimine Form of Serine Palmitoyltransferase: STRUCTURAL, KINETIC, AND SPECTROSCOPIC ANALYSIS OF THE WILD-TYPE ENZYME AND HSAN1 MUTANT MIMICS Structural insights into the enzymatic mechanism of serine palmitoyltransferase from Sphingobacterium multivorum SPTLC1 binds ABCA1 to negatively regulate trafficking and cholesterol efflux activity of the transporter Defective CFTR increases synthesis and mass of sphingolipids that modulate membrane composition and lipid signaling.HSAN1 mutations in serine palmitoyltransferase reveal a close structure-function-phenotype relationship.Myeloid cell-specific serine palmitoyltransferase subunit 2 haploinsufficiency reduces murine atherosclerosis.The representation of protein complexes in the Protein Ontology (PRO).Deoxysphingoid bases as plasma markers in diabetes mellitus.Membranes in balance: mechanisms of sphingolipid homeostasis.Modulation of hepatitis C virus genome replication by glycosphingolipids and four-phosphate adaptor protein 2.Thematic review series: sphingolipids. New insights into sphingolipid metabolism and function in budding yeast.Sphingolipid and glycosphingolipid metabolic pathways in the era of sphingolipidomics.Cardiomyocyte specific deficiency of serine palmitoyltransferase subunit 2 reduces ceramide but leads to cardiac dysfunction.Ceramide signaling in cancer and stem cells.Myristate-derived d16:0 sphingolipids constitute a cardiac sphingolipid pool with distinct synthetic routes and functional properties.Plasma sphingolipids are biomarkers of metabolic syndrome in non-human primates maintained on a Western-style diet.Cell polarity factor Par3 binds SPTLC1 and modulates monocyte serine palmitoyltransferase activity and chemotaxis.PLP-dependent enzymes as entry and exit gates of sphingolipid metabolism.A world of sphingolipids and glycolipids in the brain--novel functions of simple lipids modified with glucose.Structural, mechanistic and regulatory studies of serine palmitoyltransferase.The role of sphingolipids in drug metabolism and transport.The role of ORMDL proteins, guardians of cellular sphingolipids, in asthma.Biological Effects of Naturally Occurring Sphingolipids, Uncommon Variants, and Their Analogs.Sphingolipid De Novo Biosynthesis: A Rheostat of Cardiovascular Homeostasis.Silencing of enzymes involved in ceramide biosynthesis causes distinct global alterations of lipid homeostasis and gene expression.A systematic comparison of all mutations in hereditary sensory neuropathy type I (HSAN I) reveals that the G387A mutation is not disease associated.Chemical and apoptotic properties of hydroxy-ceramides containing long-chain bases with unusual alkyl chain lengths.Staurosporines decrease ORMDL proteins and enhance sphingomyelin synthesis resulting in depletion of plasmalemmal phosphatidylserine.The pyridoxal 5'-phosphate (PLP)-dependent enzyme serine palmitoyltransferase (SPT): effects of the small subunits and insights from bacterial mimics of human hLCB2a HSAN1 mutations Neutrophil elastase increases airway ceramide levels via upregulation of serine palmitoyltransferase.Acceleration of the substrate Calpha deprotonation by an analogue of the second substrate palmitoyl-CoA in Serine Palmitoyltransferase.Clinical and metabolic consequences of L-serine supplementation in hereditary sensory and autonomic neuropathy type 1C.Identification and expression analysis of the zebrafish homologs of the ceramide synthase gene family.palmitoyl-CoA + serine => 3-ketosphinganine + CoASH + CO2 Palmitoyl-ceramide accumulation with necrotic cell death in A549 cells, followed by a steep increase in sphinganine content.Role of sphingolipids in senescence: implication in aging and age-related diseases

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Is the mammalian serine palmitoyltransferase a high-molecular-mass complex?

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2007 nî lūn-bûn

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2007 թուականի Յուլիսին հրատարակուած գիտական յօդուած

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2007 թվականի հուլիսին հրատարակված գիտական հոդված

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2007年の論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年論文

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2007年论文

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name

Is the mammalian serine palmitoyltransferase a high-molecular-mass complex?

@ast

Is the mammalian serine palmitoyltransferase a high-molecular-mass complex?

@en

Is the mammalian serine palmitoyltransferase a high-molecular-mass complex?

@en-gb

Is the mammalian serine palmitoyltransferase a high-molecular-mass complex?

@nl

type

label

Is the mammalian serine palmitoyltransferase a high-molecular-mass complex?

@ast

Is the mammalian serine palmitoyltransferase a high-molecular-mass complex?

@en

Is the mammalian serine palmitoyltransferase a high-molecular-mass complex?

@en-gb

Is the mammalian serine palmitoyltransferase a high-molecular-mass complex?

@nl

prefLabel

Is the mammalian serine palmitoyltransferase a high-molecular-mass complex?

@ast

Is the mammalian serine palmitoyltransferase a high-molecular-mass complex?

@en

Is the mammalian serine palmitoyltransferase a high-molecular-mass complex?

@en-gb

Is the mammalian serine palmitoyltransferase a high-molecular-mass complex?

@nl

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Biochemical Journal

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Is the mammalian serine palmitoyltransferase a high-molecular-mass complex?

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Thorsten Hornemann

http://www.w3.org/2001/XMLSchema#string

Yu Wei

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Association of the Golgi UDP-galactose transporter with UDP-galactose:ceramide galactosyltransferase allows UDP-galactose import in the endoplasmic reticulum

Mechanism of 8-amino-7-oxononanoate synthase: spectroscopic, kinetic, and crystallographic studies

The crystal structure of 8-amino-7-oxononanoate synthase: a bacterial PLP-dependent, acyl-CoA-condensing enzyme

The Ceramide-centric universe of lipid-mediated cell regulation: stress encounters of the lipid kind

Serine palmitoyl-CoA transferase (SPT) deficiency and sphingolipid levels in mice

Sorting of GPI-anchored proteins to glycolipid-enriched membrane subdomains during transport to the apical cell surface

Blue native electrophoresis for isolation of membrane protein complexes in enzymatically active form

Mutations in the yeast LCB1 and LCB2 genes, including those corresponding to the hereditary sensory neuropathy type I mutations, dominantly inactivate serine palmitoyltransferase.

Bacterial serine palmitoyltransferase: a water-soluble homodimeric prototype of the eukaryotic enzyme.

Serine palmitoyltransferase, a key enzyme of sphingolipid metabolism.

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157-64

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2700661

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10.1042/BJ20070025

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1

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405

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Arnold von Eckardstein

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2007-07-01T00:00:00Z

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17331073

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Serine palmitoyltransferase long chain base subunit 3

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1925250

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