Mutations in the yeast LCB1 and LCB2 genes, including those corresponding to the hereditary sensory neuropathy type I mutations, dominantly inactivate serine palmitoyltransferase.
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Hereditary sensory neuropathy type IIs the mammalian serine palmitoyltransferase a high-molecular-mass complex?Mutations in the SPTLC2 subunit of serine palmitoyltransferase cause hereditary sensory and autonomic neuropathy type IIdentification of small subunits of mammalian serine palmitoyltransferase that confer distinct acyl-CoA substrate specificitiesThe essential nature of sphingolipids in plants as revealed by the functional identification and characterization of the Arabidopsis LCB1 subunit of serine palmitoyltransferaseThe External Aldimine Form of Serine Palmitoyltransferase: STRUCTURAL, KINETIC, AND SPECTROSCOPIC ANALYSIS OF THE WILD-TYPE ENZYME AND HSAN1 MUTANT MIMICSStructural insights into the enzymatic mechanism of serine palmitoyltransferase from Sphingobacterium multivorumThe Saccharomyces cerevisiae YBR159w gene encodes the 3-ketoreductase of the microsomal fatty acid elongase.Autophagy regulates sphingolipid levels in the liverHSAN1 mutations in serine palmitoyltransferase reveal a close structure-function-phenotype relationship.Orm1 and Orm2 are conserved endoplasmic reticulum membrane proteins regulating lipid homeostasis and protein quality control.Hereditary sensory neuropathy type 1 is caused by the accumulation of two neurotoxic sphingolipids.A disease-causing mutation in the active site of serine palmitoyltransferase causes catalytic promiscuityHereditary sensory neuropathy type 1 mutations confer dominant negative effects on serine palmitoyltransferase, critical for sphingolipid synthesis.Oral L-serine supplementation reduces production of neurotoxic deoxysphingolipids in mice and humans with hereditary sensory autonomic neuropathy type 1.Mechanisms of disease in hereditary sensory and autonomic neuropathies.The topology of the Lcb1p subunit of yeast serine palmitoyltransferase.A post-genomic approach to understanding sphingolipid metabolism in Arabidopsis thalianaYeast sphingolipids: recent developments in understanding biosynthesis, regulation, and function.Molecular characterization of membrane-associated soluble serine palmitoyltransferases from Sphingobacterium multivorum and Bdellovibrio stolpiiHarnessing the power of yeast to elucidate the role of sphingolipids in metabolic and signaling processes pertinent to psychiatric disorders.Yeast sphingolipid metabolism: clues and connections.Substrate Availability of Mutant SPT Alters Neuronal Branching and Growth Cone Dynamics in Dorsal Root GangliaCharacterization of mutant serine palmitoyltransferase 1 in LY-B cells.Molecular genetics of hereditary sensory neuropathies.Apoptotic sphingolipid signaling by ceramides in lung endothelial cellsTopological and functional characterization of the ssSPTs, small activating subunits of serine palmitoyltransferaseGenetic mutations that prevent pain: implications for future pain medication.PLP-dependent enzymes as entry and exit gates of sphingolipid metabolism.Structural, mechanistic and regulatory studies of serine palmitoyltransferase.Nonlinear fitness consequences of variation in expression level of a eukaryotic geneSphingolipid De Novo Biosynthesis: A Rheostat of Cardiovascular Homeostasis.The uracil transporter Fur4p associates with lipid rafts.The pyridoxal 5'-phosphate (PLP)-dependent enzyme serine palmitoyltransferase (SPT): effects of the small subunits and insights from bacterial mimics of human hLCB2a HSAN1 mutationsMPK6, sphinganine and the LCB2a gene from serine palmitoyltransferase are required in the signaling pathway that mediates cell death induced by long chain bases in Arabidopsis.Mechanism of alpha-oxoamine synthases: identification of the intermediate Claisen product in the 8-amino-7-oxononanoate synthase reaction.Liver serine palmitoyltransferase activity deficiency in early life impairs adherens junctions and promotes tumorigenesis.Sphingolipids activate the endoplasmic reticulum stress surveillance pathway.Sphingolipid de novo biosynthesis is essential for intestine cell survival and barrier function.Localization, topology, and function of the LCB1 subunit of serine palmitoyltransferase in mammalian cells.
P2860
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P2860
Mutations in the yeast LCB1 and LCB2 genes, including those corresponding to the hereditary sensory neuropathy type I mutations, dominantly inactivate serine palmitoyltransferase.
description
2002 nî lūn-bûn
@nan
2002 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
Mutations in the yeast LCB1 an ...... e serine palmitoyltransferase.
@ast
Mutations in the yeast LCB1 an ...... e serine palmitoyltransferase.
@en
Mutations in the yeast LCB1 an ...... e serine palmitoyltransferase.
@nl
type
label
Mutations in the yeast LCB1 an ...... e serine palmitoyltransferase.
@ast
Mutations in the yeast LCB1 an ...... e serine palmitoyltransferase.
@en
Mutations in the yeast LCB1 an ...... e serine palmitoyltransferase.
@nl
prefLabel
Mutations in the yeast LCB1 an ...... e serine palmitoyltransferase.
@ast
Mutations in the yeast LCB1 an ...... e serine palmitoyltransferase.
@en
Mutations in the yeast LCB1 an ...... e serine palmitoyltransferase.
@nl
P2093
P356
P1476
Mutations in the yeast LCB1 an ...... e serine palmitoyltransferase.
@en
P2093
Dagmar Bacikova
Erin Monaghan
Gongshe Han
Mukil Natarajan
Robert Williams
Teresa M Dunn
P304
10194-10200
P356
10.1074/JBC.M107873200
P407
P577
2002-01-07T00:00:00Z