Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262
about
Impaired dopaminergic neurotransmission and microtubule-associated protein tau alterations in human LRRK2 transgenic miceMARK2/EMK1/Par-1Balpha phosphorylation of Rab11-family interacting protein 2 is necessary for the timely establishment of polarity in Madin-Darby canine kidney cellsMARK4 is a novel microtubule-associated proteins/microtubule affinity-regulating kinase that binds to the cellular microtubule network and to centrosomesComprehensive proteomic analysis of human Par protein complexes reveals an interconnected protein networkProtein kinase MARK/PAR-1 is required for neurite outgrowth and establishment of neuronal polarity.Role of individual MARK isoforms in phosphorylation of tau at Ser²⁶² in Alzheimer's diseasePhosphorylation controls CLIMP-63-mediated anchoring of the endoplasmic reticulum to microtubulesRegulated phosphorylation and dephosphorylation of tau protein: effects on microtubule interaction, intracellular trafficking and neurodegenerationThe yeast par-1 homologs kin1 and kin2 show genetic and physical interactions with components of the exocytic machineryThe MAP2/Tau family of microtubule-associated proteinsRegulation of Microtubule Dynamics in Axon Regeneration: Insights from C. elegansThe role of tau in neurodegenerative diseases and its potential as a therapeutic targetConformational instability of the MARK3 UBA domain compromises ubiquitin recognition and promotes interaction with the adjacent kinase domainPhosphorylation of microtubule-associated proteins MAP2 and MAP4 by the protein kinase p110mark. Phosphorylation sites and regulation of microtubule dynamicsMicrotubule/MAP-affinity regulating kinase (MARK) is activated by phenylarsine oxide in situ and phosphorylates tau within its microtubule-binding domainTau-tubulin kinase phosphorylates tau at Ser-208 and Ser-210, sites found in paired helical filament-tauMicrotubule-associated [corrected] protein 7 increases the membrane expression of transient receptor potential vanilloid 4 (TRPV4)Interaction between eye pigment genes and tau-induced neurodegeneration in Drosophila melanogasterCytoskeletal pathologies of Alzheimer diseaseStructure and regulation of MARK, a kinase involved in abnormal phosphorylation of Tau protein.High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation.Roles of tau protein in health and disease.Sequence Polymorphism and Intrinsic Structural Disorder as Related to Pathobiological Performance of the Helicobacter pylori CagA OncoproteinIdentification of oligomers at early stages of tau aggregation in Alzheimer's disease.Mechanisms of tau-induced neurodegeneration.Tau potentiates nerve growth factor-induced mitogen-activated protein kinase signaling and neurite initiation without a requirement for microtubule binding.Novel screening cascade identifies MKK4 as key kinase regulating Tau phosphorylation at Ser422.Oxidation of cysteine-322 in the repeat domain of microtubule-associated protein tau controls the in vitro assembly of paired helical filamentsInclusion-body myositis: newest concepts of pathogenesis and relation to aging and Alzheimer disease.Phosphorylation of tau at Thr212, Thr231, and Ser262 combined causes neurodegenerationLoss of Par-1a/MARK3/C-TAK1 kinase leads to reduced adiposity, resistance to hepatic steatosis, and defective gluconeogenesis.Structure and pathology of tau protein in Alzheimer disease.Loss of axonal mitochondria promotes tau-mediated neurodegeneration and Alzheimer's disease-related tau phosphorylation via PAR-1.Pseudophosphorylation of tau protein directly modulates its aggregation kinetics.Microtubule-associated protein tau as a therapeutic target in neurodegenerative disease.Soluble amyloid beta-protein dimers isolated from Alzheimer cortex directly induce Tau hyperphosphorylation and neuritic degeneration.Bimolecular fluorescence complementation; lighting-up tau-tau interaction in living cells.Induction of intracellular tau aggregation is promoted by α-synuclein seeds and provides novel insights into the hyperphosphorylation of tau.Developing pharmacological therapies for Alzheimer disease.Alzheimer neurofibrillary degeneration: significance, etiopathogenesis, therapeutics and prevention.
P2860
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P2860
Microtubule-associated protein/microtubule affinity-regulating kinase (p110mark). A novel protein kinase that regulates tau-microtubule interactions and dynamic instability by phosphorylation at the Alzheimer-specific site serine 262
description
1995 nî lūn-bûn
@nan
1995 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1995 թվականի մարտին հրատարակված գիտական հոդված
@hy
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
name
Microtubule-associated protein ...... eimer-specific site serine 262
@ast
Microtubule-associated protein ...... eimer-specific site serine 262
@en
Microtubule-associated protein ...... eimer-specific site serine 262
@en-gb
Microtubule-associated protein ...... eimer-specific site serine 262
@nl
type
label
Microtubule-associated protein ...... eimer-specific site serine 262
@ast
Microtubule-associated protein ...... eimer-specific site serine 262
@en
Microtubule-associated protein ...... eimer-specific site serine 262
@en-gb
Microtubule-associated protein ...... eimer-specific site serine 262
@nl
prefLabel
Microtubule-associated protein ...... eimer-specific site serine 262
@ast
Microtubule-associated protein ...... eimer-specific site serine 262
@en
Microtubule-associated protein ...... eimer-specific site serine 262
@en-gb
Microtubule-associated protein ...... eimer-specific site serine 262
@nl
P2093
P2860
P50
P921
P3181
P356
P1476
Microtubule-associated protein ...... eimer-specific site serine 262
@en
P2093
B Trinczek
E Mandelkow
G Schmitt-Ulms
S Illenberger
P2860
P304
P3181
P356
10.1074/JBC.270.13.7679
P407
P577
1995-03-31T00:00:00Z