High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation.
about
Phosphorylation of microtubule-associated protein tau by AMPK-related kinasesAKAP13 Rho-GEF and PKD-binding domain deficient mice develop normally but have an abnormal response to β-adrenergic-induced cardiac hypertrophyβ-carboline compounds, including harmine, inhibit DYRK1A and tau phosphorylation at multiple Alzheimer's disease-related sitessiRNA high-throughput kinase library screen identifies protein kinase, DNA-activated catalytic polypeptide to play a role in MyD88-induced IFNA2 activation and IL-8 secretion.Advances with RNA interference in Alzheimer's disease research.REST regulates DYRK1A transcription in a negative feedback loop.Harmine treatment enhances short-term memory in old rats: Dissociation of cognition and the ability to perform the procedural requirements of maze testing.Altered regulation of tau phosphorylation in a mouse model of down syndrome agingHigh-Content Screening Identifies Src Family Kinases as Potential Regulators of AR-V7 Expression and Androgen-Independent Cell Growth.Roles of eIF2α kinases in the pathogenesis of Alzheimer's disease.Advances and perspectives from genetic research: development of biological markers in Alzheimer's disease.Recent advances in the design, synthesis, and biological evaluation of selective DYRK1A inhibitors: a new avenue for a disease modifying treatment of Alzheimer's?DYRK1A inhibition as potential treatment for Alzheimer's disease.An unbiased approach to identifying tau kinases that phosphorylate tau at sites associated with Alzheimer disease.Modulation of tau phosphorylation by the kinase PKR: implications in Alzheimer's disease.Dyrk1 inhibition improves Alzheimer's disease-like pathology.Systems pharmacology.Tau phosphorylation at Alzheimer's disease-related Ser356 contributes to tau stabilization when PAR-1/MARK activity is elevated.High-Content Screening Approaches That Minimize Confounding Factors in RNAi, CRISPR, and Small Molecule Screening.The new indirubin derivative inhibitors of glycogen synthase kinase-3, 6-BIDECO and 6-BIMYEO, prevent tau phosphorylation and apoptosis induced by the inhibition of protein phosphatase-2A by okadaic acid in cultured neurons.Mice deficient in AKAP13 (BRX) develop compulsive-like behavior and increased body weight.Methods and approaches to disease mechanisms using systems kinomics.The human brainome: network analysis identifies HSPA2 as a novel Alzheimer’s disease targetCorrection of cognitive deficits in mouse models of Down syndrome by a pharmacological inhibitor of DYRK1A
P2860
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P2860
High-content siRNA screening of the kinome identifies kinases involved in Alzheimer's disease-related tau hyperphosphorylation.
description
2010 nî lūn-bûn
@nan
2010 թուականի Յունուարին հրատարակուած գիտական յօդուած
@hyw
2010 թվականի հունվարին հրատարակված գիտական հոդված
@hy
2010年の論文
@ja
2010年論文
@yue
2010年論文
@zh-hant
2010年論文
@zh-hk
2010年論文
@zh-mo
2010年論文
@zh-tw
2010年论文
@wuu
name
High-content siRNA screening o ...... ated tau hyperphosphorylation.
@ast
High-content siRNA screening o ...... ated tau hyperphosphorylation.
@en
High-content siRNA screening o ...... ated tau hyperphosphorylation.
@nl
type
label
High-content siRNA screening o ...... ated tau hyperphosphorylation.
@ast
High-content siRNA screening o ...... ated tau hyperphosphorylation.
@en
High-content siRNA screening o ...... ated tau hyperphosphorylation.
@nl
prefLabel
High-content siRNA screening o ...... ated tau hyperphosphorylation.
@ast
High-content siRNA screening o ...... ated tau hyperphosphorylation.
@en
High-content siRNA screening o ...... ated tau hyperphosphorylation.
@nl
P2093
P2860
P356
P1433
P1476
High-content siRNA screening o ...... ated tau hyperphosphorylation.
@en
P2093
Andrew Grover
Bessie Meec hoovet
Chad Dickey
Christian Beaudry
Danielle Frost
David O Azorsa
David R Holz
Dietrich A Stephan
Gargi D Basu
Gillian R Brautigam
P2860
P2888
P356
10.1186/1471-2164-11-25
P407
P577
2010-01-12T00:00:00Z
P5875
P6179
1032624002