DACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications
about
Suppression of breast tumor growth and metastasis by an engineered transcription factorNeuralized1 causes apoptosis and downregulates Notch target genes in medulloblastomaOncogenic function of DACT1 in colon cancer through the regulation of β-cateninProtein kinase A-mediated 14-3-3 association impedes human Dapper1 to promote dishevelled degradationMolecular basis underlying histone H3 lysine-arginine methylation pattern readout by Spin/Ssty repeats of Spindlin1Wnt/beta-catenin signaling and small molecule inhibitorsEpigenetic Activation of Wnt/β-Catenin Signaling in NAFLD-Associated HepatocarcinogenesisSulindac Inhibits Canonical Wnt Signaling by Blocking the PDZ Domain of the Protein DishevelledRegulation of the nascent brain vascular network by neural progenitorsDissecting epigenetic silencing complexity in the mouse lung cancer suppressor gene Cadm1Disruption of the Dapper3 gene aggravates ureteral obstruction-mediated renal fibrosis by amplifying Wnt/β-catenin signalingFunctional Characterization of D9, a Novel Deazaneplanocin A (DZNep) Analog, in Targeting Acute Myeloid Leukemia (AML)Dact1 is a postsynaptic protein required for dendrite, spine, and excitatory synapse development in the mouse forebrainPosterior malformations in Dact1 mutant mice arise through misregulated Vangl2 at the primitive streakLoss of Dact1 disrupts planar cell polarity signaling by altering dishevelled activity and leads to posterior malformation in miceAll Dact (Dapper/Frodo) scaffold proteins dimerize and exhibit conserved interactions with Vangl, Dvl, and serine/threonine kinasesZodiac: A Comprehensive Depiction of Genetic Interactions in Cancer by Integrating TCGA Data.CDKN1C (p57) is a direct target of EZH2 and suppressed by multiple epigenetic mechanisms in breast cancer cellsArsenic trioxide induces differentiation of CD133+ hepatocellular carcinoma cells and prolongs posthepatectomy survival by targeting GLI1 expression in a mouse modelCigarette smoke induces C/EBP-β-mediated activation of miR-31 in normal human respiratory epithelia and lung cancer cells.A comparative analysis of gene-expression data of multiple cancer types.Epigenetic regulation of DACT2, a key component of the Wnt signalling pathway in human lung cancer.Identification of histone deacetylase 3 as a biomarker for tumor recurrence following liver transplantation in HBV-associated hepatocellular carcinoma.Methylation of DACT2 promotes breast cancer development by activating Wnt signalingThe antioxidant protein peroxiredoxin 4 is epigenetically down regulated in acute promyelocytic leukemiaInterplay between epigenetics and metabolism in oncogenesis: mechanisms and therapeutic approachesPostgenomic technologies targeting the Wnt signaling network.Derepression of CLDN3 and CLDN4 during ovarian tumorigenesis is associated with loss of repressive histone modificationsSuperior efficacy of a combined epigenetic therapy against human mantle cell lymphoma cells.A novel genome-wide in vivo screen for metastatic suppressors in human colon cancer identifies the positive WNT-TCF pathway modulators TMED3 and SOX12.Integrative epigenome analysis identifies a Polycomb-targeted differentiation program as a tumor-suppressor event epigenetically inactivated in colorectal cancerDZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation.Cancer associated epigenetic transitions identified by genome-wide histone methylation binding profiles in human colorectal cancer samples and paired normal mucosaDvl2 promotes intestinal length and neoplasia in the ApcMin mouse model for colorectal cancer.The epigenetic modifier PRDM5 functions as a tumor suppressor through modulating WNT/β-catenin signaling and is frequently silenced in multiple tumors.Synthesis of potent dishevelled PDZ domain inhibitors guided by virtual screening and NMR studiesInferring cancer subnetwork markers using density-constrained biclusteringREGγ is associated with multiple oncogenic pathways in human cancers.Current limitations and future opportunities for epigenetic therapies.Wnt signaling in cancer
P2860
Q21135222-1B366258-E50A-444F-851E-7883440529A8Q24300058-1D24A253-4DD2-44F8-8AC7-58FD6A1CCAFFQ24311321-4DB06669-5D28-44F6-8FEA-708876C35745Q24338245-333AB355-5625-4EB8-A6B3-7BFB6C08C76CQ24338569-89FBE5BD-8B11-4598-A6CA-FEFB4DC023CCQ24597197-322316B0-37D2-46E7-B2BD-FE09153ABA5EQ26739018-43E09B12-5465-4C6A-9A57-C49601485A44Q27656739-3C3F3045-94F1-4B0D-A5F5-5E08754D8B04Q28088537-5FECBFDF-6B5F-4BE0-AE22-27540A8FB52FQ28484127-2AFDD674-70A1-433C-B978-E3D05EE837E6Q28508395-AEA1B0EB-82B3-458D-A9E9-536692420C6FQ28546856-18E3C839-5AE4-42C9-8160-F5E45F379F6FQ28585865-C0D83172-D3D3-451D-89AA-F74A14FB1D0DQ28587276-076BF92B-A83E-4D76-9AF1-EC3192FF697EQ28587453-1CE7B68E-C553-476A-94FE-2D88C98EAB79Q28594193-77222A5E-27BD-49FF-BD5B-8ACBEE5D1517Q30947772-BDFB1DB1-6616-4E69-AC57-86FDAEC1FD54Q33425892-FB0474CD-6552-4A5F-9959-348A2E44665DQ33616264-BBC5357B-68D5-42C7-8191-5218502B4C9AQ33737442-8C7EABCA-71BD-4FE4-9800-8840ECA3104BQ33742162-4BE99C19-BBFD-4851-8101-E7A497B98F56Q33771070-CC6FA24E-D40D-490B-8338-52C06533CCE2Q33785710-610EA2B2-C1BB-4C5B-B538-7F53A6431521Q33789788-002727CE-5F26-4EBD-B39F-4ADA3EC4BA94Q33809163-4BD07367-B5D4-42FF-A495-D4C0B45DD7C2Q33835913-5EB7D118-DB45-4EAF-A13A-7AD24A19B9A6Q33838680-31CAFFFB-B369-46A5-BFA5-F7975DE3897EQ33884564-F0BA201B-16F4-4DF8-88F8-FA553F43EE11Q33959993-442F516F-D0F4-4003-A7EA-E15EC31921E0Q33991455-98104246-A66F-436F-BFED-BEF8106981FCQ34007733-3374FC2D-31E5-41EB-8D8E-463CE79619CEQ34017960-26A8187F-77FF-405B-A233-5ACC206C2140Q34051772-3CACFDCE-383B-42C6-9FAB-13ADDC23BBDCQ34071294-10EFC550-2893-4D9C-82BE-88234EF1E148Q34075626-DB17AA3D-165F-434B-8A97-DB6ADA02826BQ34102113-7E0138FD-209F-48AF-AEB3-341D30EEFF7DQ34110415-3C77AE4E-99B8-4C8B-A38C-985DF49A6847Q34169076-AF26B3A7-FD09-4680-91D1-05B52270172FQ34195077-1E0EA2F7-627A-4FF2-B900-6F17A0B0FC47Q34262857-16803CB9-AFEE-4C03-8E72-613C2F744D41
P2860
DACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications
description
2008 nî lūn-bûn
@nan
2008 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
DACT3 is an epigenetic regulat ...... arget of histone modifications
@ast
DACT3 is an epigenetic regulat ...... arget of histone modifications
@en
DACT3 is an epigenetic regulat ...... arget of histone modifications
@en-gb
DACT3 is an epigenetic regulat ...... arget of histone modifications
@nl
type
label
DACT3 is an epigenetic regulat ...... arget of histone modifications
@ast
DACT3 is an epigenetic regulat ...... arget of histone modifications
@en
DACT3 is an epigenetic regulat ...... arget of histone modifications
@en-gb
DACT3 is an epigenetic regulat ...... arget of histone modifications
@nl
prefLabel
DACT3 is an epigenetic regulat ...... arget of histone modifications
@ast
DACT3 is an epigenetic regulat ...... arget of histone modifications
@en
DACT3 is an epigenetic regulat ...... arget of histone modifications
@en-gb
DACT3 is an epigenetic regulat ...... arget of histone modifications
@nl
P2093
P2860
P921
P3181
P1433
P1476
DACT3 is an epigenetic regulat ...... arget of histone modifications
@en
P2093
Benjamin N R Cheyette
Jingsong Li
Lawrence W Stanton
Mark T W Chan
Puay Leng Lee
Xiaojing Yang
P2860
P304
P3181
P356
10.1016/J.CCR.2008.04.019
P407
P577
2008-06-01T00:00:00Z