DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation. - Wikidata - wikimedia - TriplyDB

DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation.

DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation.

http://www.wikidata.org/entity/Q34017960

about

Targeting histone methyltransferases and demethylases in clinical trials for cancer therapy Rationale and Methodology of Reprogramming for Generation of Induced Pluripotent Stem Cells and Induced Neural Progenitor Cells Targeting EZH2 in cancer EZH2 in normal hematopoiesis and hematological malignancies Combating the epigenome: epigenetic drugs against non-Hodgkin's lymphoma Recent progress toward epigenetic therapies: the example of mixed lineage leukemia Dietary factors and epigenetic regulation for prostate cancer prevention Mouse models for filovirus infections Targeting activating mutations of EZH2 leads to potent cell growth inhibition in human melanoma by derepression of tumor suppressor genes Epigenetic modulators as therapeutic targets in prostate cancer EZH2 in Bladder Cancer, a Promising Therapeutic Target Diverse involvement of EZH2 in cancer epigenetics Epigenetic regulation of endothelial-cell-mediated vascular repair Nucleoside drugs induce cellular differentiation by caspase-dependent degradation of stem cell factors Genetic rearrangements can modify chromatin features at epialleles Deazaneplanocin a is a promising drug to kill multiple myeloma cells in their niche The cancer-associated CTCFL/BORIS protein targets multiple classes of genomic repeats, with a distinct binding and functional preference for humanoid-specific SVA transposable elements EZH2 inhibition as a therapeutic strategy for lymphoma with EZH2-activating mutations Epigenetics in cancer Regulation of S-adenosylhomocysteine hydrolase by lysine acetylation Epigenomic plasticity enables human pancreatic α to β cell reprogramming.The protein tyrosine phosphatase receptor type R gene is an early and frequent target of silencing in human colorectal tumorigenesis Genome-wide DNA methylation analysis identifies MEGF10 as a novel epigenetically repressed candidate tumor suppressor gene in neuroblastoma Disruption of the MYC-miRNA-EZH2 loop to suppress aggressive B-cell lymphoma survival and clonogenicity.A covalently bound inhibitor triggers EZH2 degradation through CHIP-mediated ubiquitination.Polycomb target genes are silenced in multiple myeloma.Reprogramming the cardiac field Histones and their modifications in ovarian cancer - drivers of disease and therapeutic targets.Interplay between epigenetics and metabolism in oncogenesis: mechanisms and therapeutic approaches Association of Smoking, Alcohol Use, and Betel Quid Chewing with Epigenetic Aberrations in Cancers.Role of EZH2 in cancer stem cells: from biological insight to a therapeutic target.Functional and therapeutic significance of EZH2 in urological cancers Lysine methylation promotes VEGFR-2 activation and angiogenesis.Mechanisms for enhancing cellular reprogramming Determinants of sensitivity to DZNep induced apoptosis in multiple myeloma cells.EZH2 is associated with malignant behavior in pancreatic IPMN via p27Kip1 downregulation.β-Arrestin1 promotes the progression of chronic myeloid leukaemia by regulating BCR/ABL H4 acetylation.Chemical and biochemical approaches in the study of histone methylation and demethylation Chromatin proteins and modifications as drug targets.Epigenetic control of CCR5 transcript levels in immune cells and modulation by small molecules inhibitors

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DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation.

http://www.wikidata.org/entity/Q34017960

description

2009 nî lūn-bûn

@nan

2009 թուականի Յունիսին հրատարակուած գիտական յօդուած

@hyw

2009 թվականի հունիսին հրատարակված գիտական հոդված

@hy

2009年の論文

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2009年論文

@yue

2009年論文

@zh-hant

2009年論文

@zh-hk

2009年論文

@zh-mo

2009年論文

@zh-tw

2009年论文

@wuu

name

DZNep is a global histone meth ...... t silenced by DNA methylation.

@ast

DZNep is a global histone meth ...... t silenced by DNA methylation.

@en

DZNep is a global histone meth ...... t silenced by DNA methylation.

@nl

type

label

DZNep is a global histone meth ...... t silenced by DNA methylation.

@ast

DZNep is a global histone meth ...... t silenced by DNA methylation.

@en

DZNep is a global histone meth ...... t silenced by DNA methylation.

@nl

prefLabel

DZNep is a global histone meth ...... t silenced by DNA methylation.

@ast

DZNep is a global histone meth ...... t silenced by DNA methylation.

@en

DZNep is a global histone meth ...... t silenced by DNA methylation.

@nl

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Molecular Cancer Therapeutics

P1476

DZNep is a global histone meth ...... ot silenced by DNA methylation

@en

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Christine B Yoo

http://www.w3.org/2001/XMLSchema#string

Connie C Cortez

http://www.w3.org/2001/XMLSchema#string

Masanobu Abe

http://www.w3.org/2001/XMLSchema#string

Peter A Jones

http://www.w3.org/2001/XMLSchema#string

Theresa K Kelly

http://www.w3.org/2001/XMLSchema#string

Tina Branscombe Miranda

http://www.w3.org/2001/XMLSchema#string

Victor E Marquez

http://www.w3.org/2001/XMLSchema#string

P2860

DACT3 is an epigenetic regulator of Wnt/beta-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications

A genomic sequencing protocol that yields a positive display of 5-methylcytosine residues in individual DNA strands

The epigenomics of cancer

Normal keratinization in a spontaneously immortalized aneuploid human keratinocyte cell line

The polycomb group protein EZH2 is involved in progression of prostate cancer

Synergy of demethylation and histone deacetylase inhibition in the re-expression of genes silenced in cancer

Distinct localization of histone H3 acetylation and H3-K4 methylation to the transcription start sites in the human genome.

Histone H3 lysine 4 demethylation is a target of nonselective antidepressive medications.

Neplanocin A. A potent inhibitor of S-adenosylhomocysteine hydrolase and of vaccinia virus multiplication in mouse L929 cells.

3-Deazaneplanocin A: a new inhibitor of S-adenosylhomocysteine synthesis and its effects in human colon carcinoma cells.

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1579-1588

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scholarly article

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10.1158/1535-7163.MCT-09-0013

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6

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8

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2009-06-09T00:00:00Z

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26278831

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19509260

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DNA methylation

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3186068

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