Myc sensitizes p53-deficient cancer cells to the DNA-damaging effects of the DNA methyltransferase inhibitor decitabine
about
Chk2 deficiency in Myc overexpressing lymphoma cells elicits a synergistic lethal response in combination with PARP inhibitionBET and HDAC inhibitors induce similar genes and biological effects and synergize to kill in Myc-induced murine lymphomaAurora kinases A and B are up-regulated by Myc and are essential for maintenance of the malignant state.Mouse genetics suggests cell-context dependency for Myc-regulated metabolic enzymes during tumorigenesisNetwork modeling of CDF treated pancreatic cancer cells reveals a novel c-myc-p73 dependent apoptotic mechanism.5-aza-2'-deoxycytidine-induced genome rearrangements are mediated by DNMT1.The cellular ataxia telangiectasia-mutated kinase promotes epstein-barr virus lytic reactivation in response to multiple different types of lytic reactivation-inducing stimuliTargeting MYC in cancer therapy: RNA processing offers new opportunities.ENMD-2076 for hematological malignancies.The direct Myc target Pim3 cooperates with other Pim kinases in supporting viability of Myc-induced B-cell lymphomas.The DNA methyltransferase inhibitors zebularine and decitabine induce mitochondria-mediated apoptosis and DNA damage in p53 mutant leukemic T cells.Decitabine-induced apoptosis is derived by Puma and Noxa induction in chronic myeloid leukemia cell line as well as in PBL and is potentiated by SAHA.High DNA methyltransferase 3B expression mediates 5-aza-deoxycytidine hypersensitivity in testicular germ cell tumors.p53 and DNA methylation suppress the TRAIN to cell death.Role of BCL2L10 methylation and TET2 mutations in higher risk myelodysplastic syndromes treated with 5-Azacytidine
P2860
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P2860
Myc sensitizes p53-deficient cancer cells to the DNA-damaging effects of the DNA methyltransferase inhibitor decitabine
description
2009 nî lūn-bûn
@nan
2009 թուականի Ապրիլին հրատարակուած գիտական յօդուած
@hyw
2009 թվականի ապրիլին հրատարակված գիտական հոդված
@hy
2009年の論文
@ja
2009年論文
@yue
2009年論文
@zh-hant
2009年論文
@zh-hk
2009年論文
@zh-mo
2009年論文
@zh-tw
2009年论文
@wuu
name
Myc sensitizes p53-deficient c ...... ansferase inhibitor decitabine
@ast
Myc sensitizes p53-deficient c ...... ansferase inhibitor decitabine
@en
Myc sensitizes p53-deficient c ...... ansferase inhibitor decitabine
@en-gb
Myc sensitizes p53-deficient c ...... ansferase inhibitor decitabine
@nl
type
label
Myc sensitizes p53-deficient c ...... ansferase inhibitor decitabine
@ast
Myc sensitizes p53-deficient c ...... ansferase inhibitor decitabine
@en
Myc sensitizes p53-deficient c ...... ansferase inhibitor decitabine
@en-gb
Myc sensitizes p53-deficient c ...... ansferase inhibitor decitabine
@nl
prefLabel
Myc sensitizes p53-deficient c ...... ansferase inhibitor decitabine
@ast
Myc sensitizes p53-deficient c ...... ansferase inhibitor decitabine
@en
Myc sensitizes p53-deficient c ...... ansferase inhibitor decitabine
@en-gb
Myc sensitizes p53-deficient c ...... ansferase inhibitor decitabine
@nl
P2093
P921
P1433
P1476
Myc sensitizes p53-deficient c ...... ansferase inhibitor decitabine
@en
P2093
Andreas Höglund
Jonas A Nilsson
Kirsteen H Maclean
Linus Plym Forshell
Lisa M Nilsson
P304
P356
10.1182/BLOOD-2008-10-183475
P407
P577
2009-04-30T00:00:00Z