Aurora kinases A and B are up-regulated by Myc and are essential for maintenance of the malignant state. - Wikidata - wikimedia - TriplyDB

Aurora kinases A and B are up-regulated by Myc and are essential for maintenance of the malignant state.

Aurora kinases A and B are up-regulated by Myc and are essential for maintenance of the malignant state.

http://www.wikidata.org/entity/Q34124945

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Current challenges and novel treatment strategies in double hit lymphomas Functional Significance of Aurora Kinases-p53 Protein Family Interactions in Cancer Drugging the addict: non-oncogene addiction as a target for cancer therapy Transcriptional control of mitosis: deregulation and cancer Chk2 deficiency in Myc overexpressing lymphoma cells elicits a synergistic lethal response in combination with PARP inhibition Inhibition of Aurora kinase B is important for biologic activity of the dual inhibitors of BCR-ABL and Aurora kinases R763/AS703569 and PHA-739358 in BCR-ABL transformed cells Selective Targeting of CTNBB1-, KRAS- or MYC-Driven Cell Growth by Combinations of Existing Drugs Inhibition of mTOR-kinase destabilizes MYCN and is a potential therapy for MYCN-dependent tumors SMARCA4-inactivating mutations increase sensitivity to Aurora kinase A inhibitor VX-680 in non-small cell lung cancers MYC on the path to cancer Androgen receptor promotes ligand-independent prostate cancer progression through c-Myc upregulation Phase II study of alisertib, a selective Aurora A kinase inhibitor, in relapsed and refractory aggressive B- and T-cell non-Hodgkin lymphomas Phase II Intergroup Trial of Alisertib in Relapsed and Refractory Peripheral T-Cell Lymphoma and Transformed Mycosis Fungoides: SWOG 1108.Three steps to the immortality of cancer cells: senescence, polyploidy and self-renewal.Integrated analysis of genome-wide copy number alterations and gene expression in microsatellite stable, CpG island methylator phenotype-negative colon cancer.Aurora kinases: novel therapy targets in cancers Targeting high Aurora kinases expression as an innovative therapy for hepatocellular carcinoma.SIX3, a tumor suppressor, inhibits astrocytoma tumorigenesis by transcriptional repression of AURKA/B.Comparison of selected gene expression profiles in sensitive and resistant cancer cells treated with doxorubicin and Selol Small cell lung cancer: where do we go from here?The ARF tumor suppressor prevents chromosomal instability and ensures mitotic checkpoint fidelity through regulation of Aurora B.Cks1 is required for tumor cell proliferation but not sufficient to induce hematopoietic malignancies Myc-induced SUMOylation is a therapeutic vulnerability for B-cell lymphoma.Visual gene-network analysis reveals the cancer gene co-expression in human endometrial cancer Update on aurora kinase inhibitors in gynecologic malignancies.Targeting the MYC and PI3K pathways eliminates leukemia-initiating cells in T-cell acute lymphoblastic leukemia Melanoma patient-derived xenografts accurately model the disease and develop fast enough to guide treatment decisions.Bmi1 drives stem-like properties and is associated with migration, invasion, and poor prognosis in tongue squamous cell carcinoma.Update on Aurora Kinase Targeted Therapeutics in Oncology.GP130 activation induces myeloma and collaborates with MYC.Alisertib added to rituximab and vincristine is synthetic lethal and potentially curative in mice with aggressive DLBCL co-overexpressing MYC and BCL2.Site-specific programming of the host epithelial transcriptome by the gut microbiota Mechanism of action and therapeutic efficacy of Aurora kinase B inhibition in MYC overexpressing medulloblastoma.Aurora kinase inhibition overcomes cetuximab resistance in squamous cell cancer of the head and neck Combined inhibition of MEK and Aurora A kinase in KRAS/PIK3CA double-mutant colorectal cancer models.Direct and indirect targeting of MYC to treat acute myeloid leukemia Small cell lung cancer: will recent progress lead to improved outcomes?Aurora A is differentially expressed in gliomas, is associated with patient survival in glioblastoma and is a potential chemotherapeutic target in gliomas.MYC Is a Major Determinant of Mitotic Cell Fate.Metformin suppresses growth of human head and neck squamous cell carcinoma via global inhibition of protein translation.

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Aurora kinases A and B are up-regulated by Myc and are essential for maintenance of the malignant state.

http://www.wikidata.org/entity/Q34124945

description

2010 nî lūn-bûn

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2010 թուականի Յունիսին հրատարակուած գիտական յօդուած

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2010 թվականի հունիսին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Aurora kinases A and B are up- ...... enance of the malignant state.

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Aurora kinases A and B are up- ...... enance of the malignant state.

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Aurora kinases A and B are up- ...... enance of the malignant state.

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type

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Aurora kinases A and B are up- ...... enance of the malignant state.

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Aurora kinases A and B are up- ...... enance of the malignant state.

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Aurora kinases A and B are up- ...... enance of the malignant state.

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prefLabel

Aurora kinases A and B are up- ...... enance of the malignant state.

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Aurora kinases A and B are up- ...... enance of the malignant state.

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Aurora kinases A and B are up- ...... enance of the malignant state.

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BLOOD-2009-11-251074

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Aurora kinases A and B are up- ...... tenance of the malignant state

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Alexander Hoellein

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Andrei Goga

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Christian Peschel

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John L Cleveland

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Jonas A Nilsson

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Justus Duyster

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Jürgen den Hollander

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Marcus Kremer

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Mark A Hall

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Markus Scheerer

http://www.w3.org/2001/XMLSchema#string

P2860

Max: a helix-loop-helix zipper protein that forms a sequence-specific DNA-binding complex with Myc

Stabilization of N-Myc is a critical function of Aurora A in human neuroblastoma

Myc sensitizes p53-deficient cancer cells to the DNA-damaging effects of the DNA methyltransferase inhibitor decitabine

Direct induction of cyclin D2 by Myc contributes to cell cycle progression and sequestration of p27.

c-Myc accelerates S-phase and requires WRN to avoid replication stress

The Myc/Max/Mad network and the transcriptional control of cell behavior

Myc pathways provoking cell suicide and cancer

c-Myc binds to human ribosomal DNA and stimulates transcription of rRNA genes by RNA polymerase I

Myc rescue of a mutant CSF-1 receptor impaired in mitogenic signalling

Non-transcriptional control of DNA replication by c-Myc

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1498-1505

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scholarly article

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10.1182/BLOOD-2009-11-251074

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9

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116

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Andreas K. Buck

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44646212

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20519624

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