A point mutation of the alpha 2-adrenoceptor that blocks coupling to potassium but not calcium currents
about
Analysis of the relative interactions between the alpha 2C10 adrenoceptor and the guanine-nucleotide-binding proteins G(o)1 alpha and Gi 2 alpha following co-expression of these polypeptides in rat 1 fibroblastsHeterozygous alpha 2A-adrenergic receptor mice unveil unique therapeutic benefits of partial agonists.The 2.1 Å Resolution Structure of Cyanopindolol-Bound β1-Adrenoceptor Identifies an Intramembrane Na+ Ion that Stabilises the Ligand-Free ReceptorContribution of alpha(2) receptor subtypes to nerve injury-induced pain and its regulation by dexmedetomidineEffect of chronic clonidine treatment on transmitter release from sympathetic varicosities of the guinea-pig vas deferensPlacental alpha(2)-adrenoceptors control vascular development at the interface between mother and embryoAdenylyl cyclase inhibition and altered G protein subunit expression and ADP-ribosylation patterns in tissues and cells from Gi2 alpha-/-miceRandom mutagenesis of the M3 muscarinic acetylcholine receptor expressed in yeast: identification of second-site mutations that restore function to a coupling-deficient mutant M3 receptor.Mutational analysis of the structure and function of opioid receptors.Mechanisms regulating hypoxic respiratory depression during fetal and postnatal life.Insect G protein-coupled receptors and signal transduction.Physiological significance of alpha(2)-adrenergic receptor subtype diversity: one receptor is not enough.Molecular Architecture of G Protein-Coupled Receptors.Delineation of a region in the B2 bradykinin receptor that is essential for high-affinity agonist binding.Cellular consequences of stress and depression.Structure, function, and regulation of adrenergic receptors.Dual allosteric modulation of opioid antinociceptive potency by α2A-adrenoceptors.Mutation of Asp74 of the rat angiotensin II receptor confers changes in antagonist affinities and abolishes G-protein coupling.Substitution of a mutant alpha2a-adrenergic receptor via "hit and run" gene targeting reveals the role of this subtype in sedative, analgesic, and anesthetic-sparing responses in vivoNeuroprotection by alpha 2-adrenergic agonists in cerebral ischemia.G protein regulation of cardiac muscarinic potassium channel.Activation and deactivation kinetics of alpha 2A- and alpha 2C-adrenergic receptor-activated G protein-activated inwardly rectifying K+ channel currents.Molecular pharmacology of alpha 2-adrenoceptor subtypes.Mutations and diseases of G protein coupled receptors.Factors determining specificity of signal transduction by G-protein-coupled receptors. Regulation of signal transfer from receptor to G-protein.Transduction is a major factor influencing receptor characterization.Epitope-tagged receptor knock-in mice reveal that differential desensitization of alpha2-adrenergic responses is because of ligand-selective internalizationThe regulator of G protein signaling RGS4 selectively enhances alpha 2A-adreoreceptor stimulation of the GTPase activity of Go1alpha and Gi2alpha.Protection in glutamate-induced neurotoxicity by imidazoline receptor agonist moxonidine.The Functional Microdomain in Transmembrane Helices 2 and 7 Regulates Expression, Activation, and Coupling Pathways of the Gonadotropin-releasing Hormone Receptor
P2860
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P2860
A point mutation of the alpha 2-adrenoceptor that blocks coupling to potassium but not calcium currents
description
1992 nî lūn-bûn
@nan
1992 թուականի Օգոստոսին հրատարակուած գիտական յօդուած
@hyw
1992 թվականի օգոստոսին հրատարակված գիտական հոդված
@hy
1992年の論文
@ja
1992年論文
@yue
1992年論文
@zh-hant
1992年論文
@zh-hk
1992年論文
@zh-mo
1992年論文
@zh-tw
1992年论文
@wuu
name
A point mutation of the alpha ...... ssium but not calcium currents
@ast
A point mutation of the alpha ...... ssium but not calcium currents
@en
A point mutation of the alpha ...... ssium but not calcium currents
@en-gb
A point mutation of the alpha ...... ssium but not calcium currents
@nl
type
label
A point mutation of the alpha ...... ssium but not calcium currents
@ast
A point mutation of the alpha ...... ssium but not calcium currents
@en
A point mutation of the alpha ...... ssium but not calcium currents
@en-gb
A point mutation of the alpha ...... ssium but not calcium currents
@nl
prefLabel
A point mutation of the alpha ...... ssium but not calcium currents
@ast
A point mutation of the alpha ...... ssium but not calcium currents
@en
A point mutation of the alpha ...... ssium but not calcium currents
@en-gb
A point mutation of the alpha ...... ssium but not calcium currents
@nl
P2093
P356
P1433
P1476
A point mutation of the alpha ...... ssium but not calcium currents
@en
P2093
A Surprenant
D A Horstman
H Akbarali
L E Limbird
P304
P356
10.1126/SCIENCE.1354394
P407
P577
1992-08-14T00:00:00Z