Mutation of Asp74 of the rat angiotensin II receptor confers changes in antagonist affinities and abolishes G-protein coupling.
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The 2.1 Å Resolution Structure of Cyanopindolol-Bound β1-Adrenoceptor Identifies an Intramembrane Na+ Ion that Stabilises the Ligand-Free ReceptorBiased signaling of the angiotensin II type 1 receptor can be mediated through distinct mechanismsTM2-TM7 interaction in coupling movement of transmembrane helices to activation of the angiotensin II type-1 receptorRenin-angiotensin system genes in kidney development.Random mutagenesis of the M3 muscarinic acetylcholine receptor expressed in yeast: identification of second-site mutations that restore function to a coupling-deficient mutant M3 receptor.Allosteric sodium in class A GPCR signalingGbeta gamma -independent constitutive association of Galpha s with SHP-1 and angiotensin II receptor AT2 is essential in AT2-mediated ITIM-independent activation of SHP-11-Sarcosine-angiotensin II infusion effects on food intake, weight loss, energy expenditure, and skeletal muscle UCP3 gene expression in a rat modelProton transfer-mediated GPCR activationMutational analysis of the interaction of the N- and C-terminal ends of angiotensin II with the rat AT(1A) receptorDifferential gene regulation by selective association of transcriptional coactivators and bZIP DNA-binding domainsNew insights and perspectives on intrarenal renin-angiotensin system: focus on intracrine/intracellular angiotensin IIMolecular Architecture of G Protein-Coupled Receptors.Gain-of-function mutant of angiotensin II receptor, type 1A, causes hypertension and cardiovascular fibrosis in mice.Structural Basis for Ligand Recognition and Functional Selectivity at Angiotensin ReceptorGPCR activation: protonation and membrane potentialDependence of agonist activation on a conserved apolar residue in the third intracellular loop of the AT1 angiotensin receptor.Polar residues in the transmembrane domains of the type 1 angiotensin II receptor are required for binding and coupling. Reconstitution of the binding site by co-expression of two deficient mutants.Review: Structural requirements for signalling and regulation of AT1-receptors.Constitutive internalization of constitutively active agiotensin II AT(1A) receptor mutants is blocked by inverse agonists.Tyrosine kinase activation by the angiotensin II receptor in the absence of calcium signaling.Stable expression of a truncated AT1A receptor in CHO-K1 cells. The carboxyl-terminal region directs agonist-induced internalization but not receptor signaling or desensitization.Critical hydrogen bond formation for activation of the angiotensin II type 1 receptor.Agonist-induced phosphorylation of the angiotensin II (AT(1A)) receptor requires generation of a conformation that is distinct from the inositol phosphate-signaling state.Constitutive activation of angiotensin II type 1 receptor alters the orientation of transmembrane Helix-2.Interaction of a non-peptide agonist with angiotensin II AT1 receptor mutants.Intracellular third loop domain of angiotensin II type-2 receptor. Role in mediating signal transduction and cellular function.Allosteric Coupling of Drug Binding and Intracellular Signaling in the A2A Adenosine Receptor.A Conserved NPLFY Sequence Contributes to Agonist Binding and Signal Transduction but Is Not an Internalization Signal for the Type 1 Angiotensin II Receptor
P2860
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P2860
Mutation of Asp74 of the rat angiotensin II receptor confers changes in antagonist affinities and abolishes G-protein coupling.
description
1993 nî lūn-bûn
@nan
1993年の論文
@ja
1993年学术文章
@wuu
1993年学术文章
@zh-cn
1993年学术文章
@zh-hans
1993年学术文章
@zh-my
1993年学术文章
@zh-sg
1993年學術文章
@yue
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1993年學術文章
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name
Mutation of Asp74 of the rat a ...... abolishes G-protein coupling.
@ast
Mutation of Asp74 of the rat a ...... abolishes G-protein coupling.
@en
type
label
Mutation of Asp74 of the rat a ...... abolishes G-protein coupling.
@ast
Mutation of Asp74 of the rat a ...... abolishes G-protein coupling.
@en
prefLabel
Mutation of Asp74 of the rat a ...... abolishes G-protein coupling.
@ast
Mutation of Asp74 of the rat a ...... abolishes G-protein coupling.
@en
P2093
P2860
P356
P1476
Mutation of Asp74 of the rat a ...... d abolishes G-protein coupling
@en
P2093
P2860
P304
P356
10.1073/PNAS.90.11.5133
P407
P577
1993-06-01T00:00:00Z