DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system
about
Repeated phosphopeptide motifs in human Claspin are phosphorylated by Chk1 and mediate Claspin function14-3-3gamma mediates Cdc25A proteolysis to block premature mitotic entry after DNA damageClaspin operates downstream of TopBP1 to direct ATR signaling towards Chk1 activationStructure-Guided Evolution of Potent and Selective CHK1 Inhibitors through Scaffold MorphingRegulation of Claspin degradation by the ubiquitin-proteosome pathway during the cell cycle and in response to ATR-dependent checkpoint activationCleavage of claspin by caspase-7 during apoptosis inhibits the Chk1 pathwayRoles of Chk1 in cell biology and cancer therapyNetwork architecture of signaling from uncoupled helicase-polymerase to cell cycle checkpoints and trans-lesion DNA synthesis.Reconstitution of RPA-covered single-stranded DNA-activated ATR-Chk1 signaling.Drf1-dependent kinase interacts with Claspin through a conserved protein motif.IKK and NF-kappaB-mediated regulation of Claspin impacts on ATR checkpoint function.A gemcitabine sensitivity screen identifies a role for NEK9 in the replication stress responseRNAi screen of the protein kinome identifies checkpoint kinase 1 (CHK1) as a therapeutic target in neuroblastomaA kinome screen identifies checkpoint kinase 1 (CHK1) as a sensitizer for RRM1-dependent gemcitabine efficacy.Tethering DNA damage checkpoint mediator proteins topoisomerase IIbeta-binding protein 1 (TopBP1) and Claspin to DNA activates ataxia-telangiectasia mutated and RAD3-related (ATR) phosphorylation of checkpoint kinase 1 (Chk1)Role for casein kinase 1 in the phosphorylation of Claspin on critical residues necessary for the activation of Chk1.Extensive RPA2 hyperphosphorylation promotes apoptosis in response to DNA replication stress in CHK1 inhibited cellsPreclinical development of the novel Chk1 inhibitor SCH900776 in combination with DNA-damaging agents and antimetabolites.Reconstitution of a human ATR-mediated checkpoint response to damaged DNA.The conserved C terminus of Claspin interacts with Rad9 and promotes rapid activation of Chk1.S-phase-dependent p50/NF-кB1 phosphorylation in response to ATR and replication stress acts to maintain genomic stabilityThe clinical development candidate CCT245737 is an orally active CHK1 inhibitor with preclinical activity in RAS mutant NSCLC and Eµ-MYC driven B-cell lymphoma.Activation of claspinCdc7-dependent and -independent phosphorylation of Claspin in the induction of the DNA replication checkpointErbb2 suppresses DNA damage-induced checkpoint activation and UV-induced mouse skin tumorigenesis.Reconstitution of human claspin-mediated phosphorylation of Chk1 by the ATR (ataxia telangiectasia-mutated and rad3-related) checkpoint kinase.Coupling of human DNA excision repair and the DNA damage checkpoint in a defined in vitro system.The Chk1 inhibitor MK-8776 increases the radiosensitivity of human triple-negative breast cancer by inhibiting autophagyMultiple functions of the S-phase checkpoint mediator.Safeguarding genome integrity: the checkpoint kinases ATR, CHK1 and WEE1 restrain CDK activity during normal DNA replication.CHK1 expression in Gastric Cancer is modulated by p53 and RB1/E2F1: implications in chemo/radiotherapy response.Differential response of normal and malignant urothelial cells to CHK1 and ATM inhibitors.The checkpoint 1 kinase inhibitor LY2603618 induces cell cycle arrest, DNA damage response and autophagy in cancer cells.A conserved proliferating cell nuclear antigen-interacting protein sequence in Chk1 is required for checkpoint functionDNA damage-induced CHK1 autophosphorylation at Ser296 is regulated by an intramolecular mechanism.G2/M checkpoint stringency is a key parameter in the sensitivity of AML cells to genotoxic stress.CRL4(CDT2) targets CHK1 for PCNA-independent destruction.Decreased translation of p21waf1 mRNA causes attenuated p53 signaling in some p53 wild-type tumors.Premature chromosome condensation induced by caffeine, 2-aminopurine, staurosporine and sodium metavanadate in S-phase arrested HeLa cells is associated with a decrease in Chk1 phosphorylation, formation of phospho-H2AX and minor cytoskeletal rearraThe G2 checkpoint-a node-based molecular switch.
P2860
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P2860
DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system
description
2005 nî lūn-bûn
@nan
2005 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2005 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2005年の論文
@ja
2005年論文
@yue
2005年論文
@zh-hant
2005年論文
@zh-hk
2005年論文
@zh-mo
2005年論文
@zh-tw
2005年论文
@wuu
name
DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system
@ast
DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system
@en
DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system
@en-gb
DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system
@nl
type
label
DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system
@ast
DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system
@en
DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system
@en-gb
DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system
@nl
prefLabel
DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system
@ast
DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system
@en
DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system
@en-gb
DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system
@nl
P2860
P356
P1433
P1476
DNA-dependent phosphorylation of Chk1 and Claspin in a human cell-free system
@en
P2093
Catriona A L Clarke
Paul R Clarke
P2860
P304
P356
10.1042/BJ20041966
P407
P577
2005-06-01T00:00:00Z