Reconstitution of human claspin-mediated phosphorylation of Chk1 by the ATR (ataxia telangiectasia-mutated and rad3-related) checkpoint kinase.
about
Characterization of functional domains in human ClaspinPhosphorylation-dependent interactions between Crb2 and Chk1 are essential for DNA damage checkpointTipin-replication protein A interaction mediates Chk1 phosphorylation by ATR in response to genotoxic stress.Reconstitution of RPA-covered single-stranded DNA-activated ATR-Chk1 signaling.The DNA damage response kinases DNA-dependent protein kinase (DNA-PK) and ataxia telangiectasia mutated (ATM) Are stimulated by bulky adduct-containing DNA.Requirement of MTA1 in ATR-mediated DNA damage checkpoint function.ATR autophosphorylation as a molecular switch for checkpoint activation.In vitro analysis of the role of replication protein A (RPA) and RPA phosphorylation in ATR-mediated checkpoint signalingHERC2/USP20 coordinates CHK1 activation by modulating CLASPIN stabilityTethering DNA damage checkpoint mediator proteins topoisomerase IIbeta-binding protein 1 (TopBP1) and Claspin to DNA activates ataxia-telangiectasia mutated and RAD3-related (ATR) phosphorylation of checkpoint kinase 1 (Chk1)Role for casein kinase 1 in the phosphorylation of Claspin on critical residues necessary for the activation of Chk1.The fork and the kinase: a DNA replication tale from a CHK1 perspective.RHINO forms a stoichiometric complex with the 9-1-1 checkpoint clamp and mediates ATR-Chk1 signaling.Defining the Contribution of MC1R Physiological Ligands to ATR Phosphorylation at Ser435, a Predictor of DNA Repair in MelanocytesAnd-1 coordinates with Claspin for efficient Chk1 activation in response to replication stressThe conserved C terminus of Claspin interacts with Rad9 and promotes rapid activation of Chk1.Cyclin A/Cdk2 regulates Cdh1 and claspin during late S/G2 phase of the cell cycle.Bringing It All Together: Coupling Excision Repair to the DNA Damage Checkpoint.DNA mismatch repair and the DNA damage response.Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation.Cdc7-dependent and -independent phosphorylation of Claspin in the induction of the DNA replication checkpointDirect role for the replication protein treslin (Ticrr) in the ATR kinase-mediated checkpoint responseCoupling of human DNA excision repair and the DNA damage checkpoint in a defined in vitro system.Multiple functions of the S-phase checkpoint mediator.Beyond ATM: the protein kinase landscape of the DNA damage response.Mrc1/Claspin: a new role for regulation of origin firing.Molecular and genomic approach for understanding the gene-environment interaction between Nrf2 deficiency and carcinogenic nickel-induced DNA damage.The melanocortin signaling cAMP axis accelerates repair and reduces mutagenesis of platinum-induced DNA damage.Claspin recruits Cdc7 kinase for initiation of DNA replication in human cellsThe phosphorylation network for efficient activation of the DNA replication checkpoint in fission yeast.
P2860
Q24601538-C4A7F9D6-21CC-4E8D-A9FD-133D199B48D2Q28480998-8355D9C8-0DEB-4419-A663-92F6113CA730Q33541382-9D295FD8-DB5F-4E27-A006-1D3CAAA97920Q33628411-15FC16D9-C401-4473-9C52-363520ACC549Q33870839-38E70CE1-CF5A-46C5-BAC8-AF4030CEBBC6Q33924254-6224494E-66D6-4932-9A1A-181B6416B059Q33967609-B51A8CEF-E7FA-47E2-94FB-BA5A3124E8F3Q34403175-07D0E4B6-5F5D-4DC2-A265-C2D47BC7DCA3Q34579811-FA908736-9C0E-40C1-AC60-4EB9B6968F2FQ35010875-10E6FE66-9F67-4E5A-9CEB-2B44FFA9A5F7Q35160712-A02995A6-DF57-4B92-A549-5A6002A271F1Q35205026-685695D9-6515-4422-BA2A-4E508B469B3CQ35545178-E7245C1C-32CD-4D2C-9878-9A110D56B2C1Q35689652-1E8B06CD-72F9-4A3D-87E9-C1B7C07254DDQ36000849-9646AFDB-CABA-4B7D-9E11-DA66C8096B69Q36130072-924AAFF4-1342-40CA-81FE-E380939D9904Q36189504-BEF6DD9C-F409-429A-953D-2E4AC09325CBQ36197801-81E959E9-8302-4CE2-9AAC-6DD6D975F0D0Q36540658-AF26CD9F-74E7-49C0-BFDD-936CF11F0617Q36676420-3D747FEC-5BA0-4BB1-AFBC-905F5E161703Q36923333-06A5F4F2-BFCD-4EC4-8316-11597FCE4783Q36967311-4E9AD013-34DF-45BE-93C0-2E7F65453357Q37596367-A9100E86-6FD2-4494-AB81-AFE5BF052E9FQ37819727-E49008FD-0C61-4F83-93C0-3BBC472B563BQ37875377-0114683B-3C9C-4EF7-B76B-93C26316C86BQ39208248-9D68BF20-F4CA-40C2-9576-A1439A715CC2Q39268942-FDF922D6-2DFD-4C45-B290-AB95F7ADFCA3Q41718210-E839316E-D33F-4F46-B53E-BCD8EA5FB0D3Q41850137-70DA6128-8297-48AA-9A59-0940A1287A5DQ42488085-0E1746C7-A15E-4B14-A725-D1C177134B26
P2860
Reconstitution of human claspin-mediated phosphorylation of Chk1 by the ATR (ataxia telangiectasia-mutated and rad3-related) checkpoint kinase.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 14 October 2009
@en
vedecký článok
@sk
vetenskaplig artikel
@sv
videnskabelig artikel
@da
vědecký článek
@cs
name
Reconstitution of human claspi ...... d3-related) checkpoint kinase.
@en
Reconstitution of human claspin-mediated phosphorylation of Chk1 by the ATR
@nl
type
label
Reconstitution of human claspi ...... d3-related) checkpoint kinase.
@en
Reconstitution of human claspin-mediated phosphorylation of Chk1 by the ATR
@nl
prefLabel
Reconstitution of human claspi ...... d3-related) checkpoint kinase.
@en
Reconstitution of human claspin-mediated phosphorylation of Chk1 by the ATR
@nl
P2093
P2860
P356
P1476
Reconstitution of human claspi ...... d3-related) checkpoint kinase.
@en
P2093
Jun-Hyuk Choi
Laura A Lindsey-Boltz
Ozdemirhan Serçin
P2860
P304
33107-33114
P356
10.1074/JBC.M109.064485
P407
P50
P577
2009-10-14T00:00:00Z