Autophosphorylation of p110delta phosphoinositide 3-kinase: a new paradigm for the regulation of lipid kinases in vitro and in vivo
about
Two distinct phosphoinositide 3-kinases mediate polypeptide growth factor-stimulated PKB activation.Protein tyrosine phosphatases--from housekeeping enzymes to master regulators of signal transductionPhosphoinositides: tiny lipids with giant impact on cell regulationThe Src homology 2 domain containing inositol 5-phosphatase SHIP2 is recruited to the epidermal growth factor (EGF) receptor and dephosphorylates phosphatidylinositol 3,4,5-trisphosphate in EGF-stimulated COS-7 cellsThe intrinsically disordered tails of PTEN and PTEN-L have distinct roles in regulating substrate specificity and membrane activityPhosphoinositide 3-kinase-gamma induces Xenopus oocyte maturation via lipid kinase activityThe PI-3 kinase/Akt pathway and T cell activation: pleiotropic pathways downstream of PIP3Human phosphatidylinositol 4-kinase isoform PI4K92. Expression of the recombinant enzyme and determination of multiple phosphorylation sites.Identification and characterization of the autophosphorylation sites of phosphoinositide 3-kinase isoforms beta and gamma.Analysis of class I phosphoinositide 3-kinase autophosphorylation sites by mass spectrometry.Protein kinase activity of phosphoinositide 3-kinase regulates beta-adrenergic receptor endocytosis.Somatic mutations in PI3Kalpha: structural basis for enzyme activation and drug designA critical role for phosphoinositide 3-kinase upstream of Gab1 and SHP2 in the activation of ras and mitogen-activated protein kinases by epidermal growth factor.Functional analysis of the protein phosphatase activity of PTENOncogenic transformation induced by the p110beta, -gamma, and -delta isoforms of class I phosphoinositide 3-kinaseDistinguishing modes of eukaryotic gradient sensing.New responsibilities for the PI3K regulatory subunit p85 alpha.Phosphoinositide 3-kinase inhibition in cancer treatment.Chemokine signalling: pivoting around multiple phosphoinositide 3-kinases.Antigen receptor signalling: a distinctive role for the p110delta isoform of PI3K.Protein kinase activity of phosphoinositide 3-kinase regulates cytokine-dependent cell survivalOncogenic mutations of p110α isoform of PI 3-kinase upregulate its protein kinase activity.Regulation of phosphoinositide 3-kinase by its intrinsic serine kinase activity in vivo.Protective role of female gender in programmed accelerated renal aging in the rat.Requirement of the FATC domain of protein kinase Tel1 for localization to DNA ends and target protein recognitionPhosphatidylinositol-3,4,5-trisphosphate: tool of choice for class I PI 3-kinases.The regulation of class IA PI 3-kinases by inter-subunit interactions.Defective phosphoinositide metabolism in autism.The PI3-kinase isoform p110δ is essential for cell transformation induced by the D816V mutant of c-Kit in a lipid-kinase-independent manner.Molecular mechanism of insulin-induced degradation of insulin receptor substrate 1Human Cytomegalovirus Induces an Atypical Activation of Akt To Stimulate the Survival of Short-Lived Monocytes.Adsorption of GST-PI3Kgamma at the air-buffer interface and at substrate and nonsubstrate phospholipid monolayers.Mechanisms of nuclear vitamin D receptor resistance in Harvey-ras-transfected cells.The DNA-dependent protein kinase catalytic subunit is phosphorylated in vivo on threonine 3950, a highly conserved amino acid in the protein kinase domain.Activation loop sequences confer substrate specificity to phosphoinositide 3-kinase alpha (PI3Kalpha ). Functions of lipid kinase-deficient PI3Kalpha in signaling.Comparison of the kinetic properties of the lipid- and protein-kinase activities of the p110alpha and p110beta catalytic subunits of class-Ia phosphoinositide 3-kinases.The p110delta isoform of PI 3-kinase negatively controls RhoA and PTEN.A function for phosphoinositide 3-kinase beta lipid products in coupling beta gamma to Ras activation in response to lysophosphatidic acid.Regulation of neuroprotective activity of myocyte-enhancer factor 2 by cAMP-protein kinase A signaling pathway in neuronal survival.Characterization of Recombinant Phosphatidylinositol 4-Kinase β Reveals Auto- and Heterophosphorylation of the Enzyme
P2860
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P2860
Autophosphorylation of p110delta phosphoinositide 3-kinase: a new paradigm for the regulation of lipid kinases in vitro and in vivo
description
1999 nî lūn-bûn
@nan
1999 թուականի Մարտին հրատարակուած գիտական յօդուած
@hyw
1999 թվականի մարտին հրատարակված գիտական հոդված
@hy
1999年の論文
@ja
1999年学术文章
@wuu
1999年学术文章
@zh-cn
1999年学术文章
@zh-hans
1999年学术文章
@zh-my
1999年学术文章
@zh-sg
1999年學術文章
@yue
name
Autophosphorylation of p110del ...... d kinases in vitro and in vivo
@ast
Autophosphorylation of p110del ...... d kinases in vitro and in vivo
@en
Autophosphorylation of p110del ...... d kinases in vitro and in vivo
@nl
type
label
Autophosphorylation of p110del ...... d kinases in vitro and in vivo
@ast
Autophosphorylation of p110del ...... d kinases in vitro and in vivo
@en
Autophosphorylation of p110del ...... d kinases in vitro and in vivo
@nl
prefLabel
Autophosphorylation of p110del ...... d kinases in vitro and in vivo
@ast
Autophosphorylation of p110del ...... d kinases in vitro and in vivo
@en
Autophosphorylation of p110del ...... d kinases in vitro and in vivo
@nl
P2093
P2860
P356
P1433
P1476
Autophosphorylation of p110del ...... d kinases in vitro and in vivo
@en
P2093
B Vanhaesebroeck
M D Waterfield
S Anderson
P2860
P304
P356
10.1093/EMBOJ/18.5.1292
P407
P577
1999-03-01T00:00:00Z