Molecular mechanism of insulin-induced degradation of insulin receptor substrate 1
about
Deletion of SOCS7 leads to enhanced insulin action and enlarged islets of Langerhans.Regulation of protein tyrosine kinase signaling by substrate degradation during brain developmentDEDD regulates degradation of intermediate filaments during apoptosisAcetylation of insulin receptor substrate-1 is permissive for tyrosine phosphorylationInfluence of miRNA in insulin signaling pathway and insulin resistance: micro-molecules with a major role in type-2 diabetesThe Novel Functions of High-Molecular-Mass Complexes Containing Insulin Receptor Substrates in Mediation and Modulation of Insulin-Like Activities: Emerging Concept of Diverse Functions by IRS-Associated ProteinsHyperosmotic stress inhibits insulin receptor substrate-1 function by distinct mechanisms in 3T3-L1 adipocytesDiabetic cardiomyopathy: signaling defects and therapeutic approachesImpaired-inactivation of FoxO1 contributes to glucose-mediated increases in serum very low-density lipoproteinTOR signaling.Insulin resistance without elevated mammalian target of rapamycin complex 1 activity in muscles of mice fed a high-fat diet.Identification of WNK1 as a substrate of Akt/protein kinase B and a negative regulator of insulin-stimulated mitogenesis in 3T3-L1 cells.Phosphorylation of Ser24 in the pleckstrin homology domain of insulin receptor substrate-1 by Mouse Pelle-like kinase/interleukin-1 receptor-associated kinase: cross-talk between inflammatory signaling and insulin signaling that may contribute to inNitric oxide agents impair insulin-mediated signal transduction in rat skeletal muscleThe ubiquitin system, disease, and drug discovery.Current views on type 2 diabetes.Insulin-like growth factor-I-stimulated insulin receptor substrate-1 negatively regulates Src homology 2 domain-containing protein-tyrosine phosphatase substrate-1 function in vascular smooth muscle cells.PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injuryHigh dietary lipid level is associated with persistent hyperglycaemia and downregulation of muscle Akt-mTOR pathway in Senegalese sole (Solea senegalensis).The role of the cullin-5 e3 ubiquitin ligase in the regulation of insulin receptor substrate-1.Protein phosphatase 4 interacts with and down-regulates insulin receptor substrate 4 following tumor necrosis factor-alpha stimulation.Dephosphorylation by default, a potential mechanism for regulation of insulin receptor substrate-1/2, Akt, and ERK1/2.Cell lysis-free quantum dot multicolor cellular imaging-based mechanism study for TNF-α-induced insulin resistance.Heat shock transcription factor 1 is a key determinant of HCC development by regulating hepatic steatosis and metabolic syndrome.Disruption of the interface between the pleckstrin homology (PH) and kinase domains of Akt protein is sufficient for hydrophobic motif site phosphorylation in the absence of mTORC2Morphine induces desensitization of insulin receptor signaling.Mechanisms underlying skeletal muscle insulin resistance induced by fatty acids: importance of the mitochondrial functionProteasome alterations during adipose differentiation and aging: links to impaired adipocyte differentiation and development of oxidative stress.Protein phosphatase 4 (PP4) functions as a critical regulator in tumor necrosis factor (TNF)-α-induced hepatic insulin resistance.Identification of the degradation determinants of insulin receptor substrate 1 for signaling cullin-RING E3 ubiquitin ligase 7-mediated ubiquitination.Serine 302 Phosphorylation of Mouse Insulin Receptor Substrate 1 (IRS1) Is Dispensable for Normal Insulin Signaling and Feedback Regulation by Hepatic S6 Kinase.Rapamycin does not improve insulin sensitivity despite elevated mammalian target of rapamycin complex 1 activity in muscles of ob/ob mice.Pathogenesis of type 2 diabetes.Role of mitochondrial dysfunction in insulin resistance.Insulin concentration is critical in culturing human neural stem cells and neurons.Measures of striatal insulin resistance in a 6-hydroxydopamine model of Parkinson's diseaseBerberine reverses free-fatty-acid-induced insulin resistance in 3T3-L1 adipocytes through targeting IKKbeta.Mechanisms of high-glucose/insulin-mediated desensitization of acute insulin-stimulated glucose transport and Akt activationLipid and insulin infusion-induced skeletal muscle insulin resistance is likely due to metabolic feedback and not changes in IRS-1, Akt, or AS160 phosphorylationDeconstructing feedback-signaling networks to improve anticancer therapy with mTORC1 inhibitors.
P2860
Q24530013-3315A9DB-471C-404D-B85B-D8DA620E1D3AQ24633286-43A9E741-0BA3-41B9-8316-075A9AE90F80Q24673637-63E01D22-A7EB-477C-B57D-E77CED40A65DQ24797546-9424519B-9518-4CFE-9FB8-F3273DE94D1EQ26865641-44AB051B-C095-41ED-8E8E-13E4FE256E91Q28088661-1042CDD3-90E9-43FE-AA1D-E37171B46239Q28202364-352A0A10-9795-45D5-9600-0775EA530D33Q28395852-8A0765EC-F79A-4EDD-8AC0-16A234942650Q28583188-125B4A25-A0C3-4DCB-9952-2FAE165DA195Q30312086-DB2E7C71-7735-4C37-A68C-D30AEDEC9056Q30417125-3F964929-CD09-47BD-8F89-E476FAEBEC3FQ30781595-EDF4625C-3A5B-4320-BF3D-F225048084B4Q31162696-5F5D675E-CEDF-408F-B8BB-9AF3733546DBQ33244914-204AB702-B9A7-42FE-BDF9-F76E695C83CFQ33384295-631E46C3-8CFC-47DF-AF89-C762C5B6AAB5Q33621890-E28E6057-139D-4BEE-88AD-728FC39213A9Q33855046-4FF407D0-BC1C-4A4D-9BCF-F39B61859249Q33892209-014C3C9B-1685-49F0-A8DC-35A6B1336F6CQ33921401-BDB7DEBF-7D6C-4102-95F6-D3DE8096A26FQ34035063-BA4219FC-19EB-4154-809D-B2CCEAB1F67DQ34343619-722DCF71-85BA-49D1-8FBE-D0CE294944E5Q34577123-3C503B50-0512-4A1C-9626-3D3D726359ABQ35025082-6F10E1D1-F93E-4240-91E2-F9E1F7AFB70FQ35545513-C1AB49B3-971F-4BD9-BAF7-A86CA9CB3E69Q35604279-367F9EFF-4863-4DE7-A700-6F4AFD10D423Q35661518-2F061FF5-CB9B-444A-A01C-4261393636E6Q35854385-1B4564D5-A161-4112-A9CF-2A04F6C08049Q36043696-2EC02F92-4560-4A41-ACB9-0852BF8EB00BQ36369617-A279ACD7-BA0B-4890-88E8-83F59738C635Q36418948-27594BB9-4A71-4B01-96E3-B369886B20EBQ36884668-C8F32B4C-2103-460C-8C9C-A2FD1361A555Q36977162-48B3CFF0-DDF0-45AF-BCD3-374B330B1BD7Q37083597-BA0D5E97-B28D-454B-A7CB-D0DDEBF32F9AQ37097807-C20440A3-9E35-406A-BC8B-EBC2C055C364Q37148293-31565B35-CF59-4A2E-B127-445B70537235Q37151436-C4DA432B-938F-4FBD-83B2-36217C009A16Q37203815-241D23B0-143E-4FA4-81CD-53FCD776E143Q37243975-6836F790-F49C-45AB-BDF0-C76CC3FB34D7Q37264198-50B4CA8D-2F80-4281-B228-FD648F5B7EECQ37355543-BC016985-8000-4FCC-8ACB-5A062191C9FD
P2860
Molecular mechanism of insulin-induced degradation of insulin receptor substrate 1
description
2002 nî lūn-bûn
@nan
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
2002年论文
@zh
2002年论文
@zh-cn
name
Molecular mechanism of insulin-induced degradation of insulin receptor substrate 1
@en
Molecular mechanism of insulin-induced degradation of insulin receptor substrate 1.
@nl
type
label
Molecular mechanism of insulin-induced degradation of insulin receptor substrate 1
@en
Molecular mechanism of insulin-induced degradation of insulin receptor substrate 1.
@nl
prefLabel
Molecular mechanism of insulin-induced degradation of insulin receptor substrate 1
@en
Molecular mechanism of insulin-induced degradation of insulin receptor substrate 1.
@nl
P2093
P2860
P1476
Molecular mechanism of insulin-induced degradation of insulin receptor substrate 1
@en
P2093
John J Mitchell
Rachel Zhande
Xiao Jian Sun
P2860
P304
P356
10.1128/MCB.22.4.1016-1026.2002
P407
P577
2002-02-01T00:00:00Z