Base pairing with U6atac snRNA is required for 5' splice site activation of U12-dependent introns in vivo.
about
The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosomeRecycling of the U12-type spliceosome requires p110, a component of the U6atac snRNPConservation of functional features of U6atac and U12 snRNAs between vertebrates and higher plantsDomains of human U4atac snRNA required for U12-dependent splicing in vivoAn intronic enhancer regulates splicing of the twintron of Drosophila melanogaster prospero pre-mRNA by two different spliceosomesSplicing of a rare class of introns by the U12-dependent spliceosomeThe significant other: splicing by the minor spliceosomeA ribozyme selected from variants of U6 snRNA promotes 2',5'-branch formationA mutation in a rare type of intron in a sodium-channel gene results in aberrant splicing and causes myotonia.AT-AC pre-mRNA splicing mechanisms and conservation of minor introns in voltage-gated ion channel genes.Gene expression profiling of U12-type spliceosome mutant Drosophila reveals widespread changes in metabolic pathwaysU4 small nuclear RNA can function in both the major and minor spliceosomes.mRNA localization signals can enhance the intracellular effectiveness of hammerhead ribozymesA limited number of pseudouridine residues in the human atac spliceosomal UsnRNAs as compared to human major spliceosomal UsnRNAsThe intramolecular stem-loop structure of U6 snRNA can functionally replace the U6atac snRNA stem-loopAlternative splicing of U12-dependent introns in vivo responds to purine-rich enhancersA mutational analysis of U12-dependent splice site dinucleotides.The abundance of the spliceosomal snRNPs is not limiting the splicing of U12-type introns.Initial recognition of U12-dependent introns requires both U11/5' splice-site and U12/branchpoint interactionsFunctionally important structural elements of U12 snRNAComputational screen for spliceosomal RNA genes aids in defining the phylogenetic distribution of major and minor spliceosomal components.Where in the cell is the minor spliceosome?Mutational analysis of the U12-dependent branch site consensus sequence.The Arabidopsis homolog of human minor spliceosomal protein U11-48K plays a crucial role in U12 intron splicing and plant developmentU6atac snRNA stem-loop interacts with U12 p65 RNA binding protein and is functionally interchangeable with the U12 apical stem-loop III.The conserved 3' end domain of U6atac snRNA can direct U6 snRNA to the minor spliceosome.The U11-48K protein contacts the 5' splice site of U12-type introns and the U11-59K protein.Human U4/U6.U5 and U4atac/U6atac.U5 tri-snRNPs exhibit similar protein compositions.Protein-free spliceosomal snRNAs catalyze a reaction that resembles the first step of splicing.Minor splicing snRNAs are enriched in the developing mouse CNS and are crucial for survival of differentiating retinal neurons.Purine-rich enhancers function in the AT-AC pre-mRNA splicing pathway and do so independently of intact U1 snRNP.Proximity of the U12 snRNA with both the 5' splice site and the branch point during early stages of spliceosome assemblyDeterminants of plant U12-dependent intron splicing efficiency.The Arabidopsis U11/U12-65K is an indispensible component of minor spliceosome and plays a crucial role in U12 intron splicing and plant development.
P2860
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P2860
Base pairing with U6atac snRNA is required for 5' splice site activation of U12-dependent introns in vivo.
description
1998 nî lūn-bûn
@nan
1998 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1998 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1998年の論文
@ja
1998年論文
@yue
1998年論文
@zh-hant
1998年論文
@zh-hk
1998年論文
@zh-mo
1998年論文
@zh-tw
1998年论文
@wuu
name
Base pairing with U6atac snRNA ...... U12-dependent introns in vivo
@nl
Base pairing with U6atac snRNA ...... U12-dependent introns in vivo.
@ast
Base pairing with U6atac snRNA ...... U12-dependent introns in vivo.
@en
type
label
Base pairing with U6atac snRNA ...... U12-dependent introns in vivo
@nl
Base pairing with U6atac snRNA ...... U12-dependent introns in vivo.
@ast
Base pairing with U6atac snRNA ...... U12-dependent introns in vivo.
@en
prefLabel
Base pairing with U6atac snRNA ...... U12-dependent introns in vivo
@nl
Base pairing with U6atac snRNA ...... U12-dependent introns in vivo.
@ast
Base pairing with U6atac snRNA ...... U12-dependent introns in vivo.
@en
P2860
P3181
P1433
P1476
Base pairing with U6atac snRNA ...... U12-dependent introns in vivo.
@en
P2093
R A Padgett
R Incorvaia
P2860
P304
P3181
P356
10.1017/S1355838298980207
P407
P577
1998-06-01T00:00:00Z