Initial recognition of U12-dependent introns requires both U11/5' splice-site and U12/branchpoint interactions - Wikidata - wikimedia - TriplyDB

Initial recognition of U12-dependent introns requires both U11/5' splice-site and U12/branchpoint interactions

Initial recognition of U12-dependent introns requires both U11/5' splice-site and U12/branchpoint interactions

http://www.wikidata.org/entity/Q35193277

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The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome A novel U2 and U11/U12 snRNP protein that associates with the pre-mRNA branch site.Prp5 bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA Evolutionary conservation of minor U12-type spliceosome between plants and humans Targeted 'knockdown' of spliceosome function in mammalian cells An intronic enhancer regulates splicing of the twintron of Drosophila melanogaster prospero pre-mRNA by two different spliceosomes U12DB: a database of orthologous U12-type spliceosomal introns Functional stabilization of an RNA recognition motif by a noncanonical N-terminal expansion Identification of an evolutionarily divergent U11 small nuclear ribonucleoprotein particle in Drosophila Splicing of a rare class of introns by the U12-dependent spliceosome The significant other: splicing by the minor spliceosome Structural and mechanistic insights into human splicing factor SF3b complex derived using an integrated approach guided by the cryo-EM density maps RNA structure analysis of human spliceosomes reveals a compact 3D arrangement of snRNAs at the catalytic core.The minor spliceosomal protein U11/U12-31K is an RNA chaperone crucial for U12 intron splicing and the development of dicot and monocot plants.Splicing of U12-type introns deposits an exon junction complex competent to induce nonsense-mediated mRNA decay.Gene expression profiling of U12-type spliceosome mutant Drosophila reveals widespread changes in metabolic pathways Global analysis of the nuclear processing of transcripts with unspliced U12-type introns by the exosome.The U11/U12 snRNP 65K protein acts as a molecular bridge, binding the U12 snRNA and U11-59K protein Role of the 3' splice site in U12-dependent intron splicing Kaposi's sarcoma-associated herpesvirus K8beta is derived from a spliced intermediate of K8 pre-mRNA and antagonizes K8alpha (K-bZIP) to induce p21 and p53 and blocks K8alpha-CDK2 interaction Ribonucleoprotein multimers and their functions.Functions of SR proteins in the U12-dependent AT-AC pre-mRNA splicing pathway.Branchpoint selection in the splicing of U12-dependent introns in vitro Comprehensive splice-site analysis using comparative genomics.The abundance of the spliceosomal snRNPs is not limiting the splicing of U12-type introns.Interpretation of mRNA splicing mutations in genetic disease: review of the literature and guidelines for information-theoretical analysis.ATP can be dispensable for prespliceosome formation in yeast Identification, characterization and molecular phylogeny of U12-dependent introns in the Arabidopsis thaliana genome.Functionally important structural elements of U12 snRNA Transcriptional co-activator protein p100 interacts with snRNP proteins and facilitates the assembly of the spliceosome Regulation of gene expression through inefficient splicing of U12-type introns Alternative exon definition events control the choice between nuclear retention and cytoplasmic export of U11/U12-65K mRNA.Computational screen for spliceosomal RNA genes aids in defining the phylogenetic distribution of major and minor spliceosomal components.Mutational analysis of the U12-dependent branch site consensus sequence.The Arabidopsis homolog of human minor spliceosomal protein U11-48K plays a crucial role in U12 intron splicing and plant development Structural features important for the U12 snRNA binding and minor spliceosome assembly of Arabidopsis U11/U12-small nuclear ribonucleoproteins.Minor class splicing shapes the zebrafish transcriptome during development.Defective minor spliceosome mRNA processing results in isolated familial growth hormone deficiency.RNA biology in a test tube--an overview of in vitro systems/assays.The U11-48K protein contacts the 5' splice site of U12-type introns and the U11-59K protein.

P2860

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P2860

Initial recognition of U12-dependent introns requires both U11/5' splice-site and U12/branchpoint interactions

http://www.wikidata.org/entity/Q35193277

description

1999 nî lūn-bûn

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1999 թուականի Ապրիլին հրատարակուած գիտական յօդուած

@hyw

1999 թվականի ապրիլին հրատարակված գիտական հոդված

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1999年の論文

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1999年論文

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1999年論文

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1999年論文

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1999年論文

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1999年論文

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1999年论文

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Initial recognition of U12-dep ...... d U12/branchpoint interactions

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Initial recognition of U12-dep ...... d U12/branchpoint interactions

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Initial recognition of U12-dep ...... d U12/branchpoint interactions

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Initial recognition of U12-dep ...... d U12/branchpoint interactions

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Initial recognition of U12-dep ...... d U12/branchpoint interactions

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Initial recognition of U12-dep ...... d U12/branchpoint interactions

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P1433

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Genes & Development

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Initial recognition of U12-dep ...... d U12/branchpoint interactions

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J A Steitz

http://www.w3.org/2001/XMLSchema#string

M J Frilander

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P2860

Evidence that sequence-independent binding of highly conserved U2 snRNP proteins upstream of the branch site is required for assembly of spliceosomal complex A

U11 snRNA interacts in vivo with the 5' splice site of U12-dependent (AU-AC) pre-mRNA introns

Base pairing with U6atac snRNA is required for 5' splice site activation of U12-dependent introns in vivo.

The spliceosome assembly pathway in mammalian extracts

Additional low-abundance human small nuclear ribonucleoproteins: U11, U12, etc

Site-specific crosslinking of mammalian U11 and u6atac to the 5' splice site of an AT-AC intron

Cross-intron bridging interactions in the yeast commitment complex are conserved in mammals

A novel base-pairing interaction between U2 and U6 snRNAs suggests a mechanism for the catalytic activation of the spliceosome

Pre-mRNA splicing: the discovery of a new spliceosome doubles the challenge

Protein-protein interactions and 5'-splice-site recognition in mammalian mRNA precursors

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851-863

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scholarly article

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10.1101/GAD.13.7.851

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7

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13100202

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10197985

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P921

U12-type prespliceosome

P932

316595

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