A RAG-1/RAG-2 tetramer supports 12/23-regulated synapsis, cleavage, and transposition of V(D)J recombination signals.
about
The RAG1 N-terminal domain is an E3 ubiquitin ligaseLack of MSH2 involvement differentiates V(D)J recombination from other non-homologous end joining eventsStructure of the RAG1 nonamer binding domain with DNA reveals a dimer that mediates DNA synapsisPutting the pieces together: identification and characterization of structural domains in the V(D)J recombination protein RAG1Recombination-activating gene proteins: more regulation, pleaseThe taming of a transposon: V(D)J recombination and the immune systemCrystal structure of the V(D)J recombinase RAG1-RAG2Self-association and conformational properties of RAG1: implications for formation of the V(D)J recombinase.Thermal dependency of RAG1 self-association properties.HMG-box domain stimulation of RAG1/2 cleavage activity is metal ion dependent.HMGB1/2 can target DNA for illegitimate cleavage by the RAG1/2 complex.Synapsis alters RAG-mediated nicking at Tcrb recombination signal sequences: implications for the “beyond 12/23” ruleRAG and HMGB1 create a large bend in the 23RSS in the V(D)J recombination synaptic complexes.HMGB1 in health and disease.Identification and characterization of a gain-of-function RAG-1 mutant.Base flipping in V(D)J recombination: insights into the mechanism of hairpin formation, the 12/23 rule, and the coordination of double-strand breaksThe architecture of the 12RSS in V(D)J recombination signal and synaptic complexes.Single-molecule analysis of RAG-mediated V(D)J DNA cleavage.Requirements for DNA hairpin formation by RAG1/2DNA cleavage activity of the V(D)J recombination protein RAG1 is autoregulated.The bounty of RAGs: recombination signal complexes and reaction outcomes.V(D)J recombination: how to tame a transposase.Assembly Pathway and Characterization of the RAG1/2-DNA Paired and Signal-end ComplexesFluorescence resonance energy transfer analysis of recombination signal sequence configuration in the RAG1/2 synaptic complex.Real-time monitoring of RAG-catalyzed DNA cleavage unveils dynamic changes in coding end association with the coding end complex.Recruitment of RAG1 and RAG2 to Chromatinized DNA during V(D)J Recombination.Evidence for Ku70/Ku80 association with full-length RAG1.Cooperative recruitment of HMGB1 during V(D)J recombination through interactions with RAG1 and DNA.RAG2's non-core domain contributes to the ordered regulation of V(D)J recombination.Quantitative analyses of RAG-RSS interactions and conformations revealed by atomic force microscopy.Full-length RAG1 promotes contact with coding and intersignal sequences in RAG protein complexes bound to recombination signals paired in cis.Initial stages of V(D)J recombination: the organization of RAG1/2 and RSS DNA in the postcleavage complex.Molecular mechanism underlying RAG1/RAG2 synaptic complex formation.Real-time analysis of RAG complex activity in V(D)J recombinationSynapsis of recombination signal sequences located in cis and DNA underwinding in V(D)J recombination.H3K4me3 induces allosteric conformational changes in the DNA-binding and catalytic regions of the V(D)J recombinaseFull-length RAG-2, and not full-length RAG-1, specifically suppresses RAG-mediated transposition but not hybrid joint formation or disintegration.RAG1-DNA binding in V(D)J recombination. Specificity and DNA-induced conformational changes revealed by fluorescence and CD spectroscopy.Mechanistic basis for RAG discrimination between recombination sites and the off-target sites of human lymphomas.Early intermediates of mariner transposition: catalysis without synapsis of the transposon ends suggests a novel architecture of the synaptic complex
P2860
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P2860
A RAG-1/RAG-2 tetramer supports 12/23-regulated synapsis, cleavage, and transposition of V(D)J recombination signals.
description
2002 nî lūn-bûn
@nan
2002 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2002 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2002年の論文
@ja
2002年論文
@yue
2002年論文
@zh-hant
2002年論文
@zh-hk
2002年論文
@zh-mo
2002年論文
@zh-tw
2002年论文
@wuu
name
A RAG-1/RAG-2 tetramer support ...... f V(D)J recombination signals.
@ast
A RAG-1/RAG-2 tetramer support ...... f V(D)J recombination signals.
@en
A RAG-1/RAG-2 tetramer support ...... f V(D)J recombination signals.
@nl
type
label
A RAG-1/RAG-2 tetramer support ...... f V(D)J recombination signals.
@ast
A RAG-1/RAG-2 tetramer support ...... f V(D)J recombination signals.
@en
A RAG-1/RAG-2 tetramer support ...... f V(D)J recombination signals.
@nl
prefLabel
A RAG-1/RAG-2 tetramer support ...... f V(D)J recombination signals.
@ast
A RAG-1/RAG-2 tetramer support ...... f V(D)J recombination signals.
@en
A RAG-1/RAG-2 tetramer support ...... f V(D)J recombination signals.
@nl
P2860
P1476
A RAG-1/RAG-2 tetramer support ...... f V(D)J recombination signals.
@en
P2093
Patrick C Swanson
P2860
P304
P356
10.1128/MCB.22.22.7790-7801.2002
P407
P577
2002-11-01T00:00:00Z