Inactivation of the NF1 gene in human melanoma and neuroblastoma cell lines without impaired regulation of GTP.Ras
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Functional expression of NF1 tumor suppressor protein: association with keratin intermediate filaments during the early development of human epidermis.Pathways and therapeutic targets in melanomaLoss of NF1 in cutaneous melanoma is associated with RAS activation and MEK dependence.Toward a survey of somatic mutation of the NF1 gene in benign neurofibromas of patients with neurofibromatosis type 1.The Nf1 tumor suppressor regulates mouse skin wound healing, fibroblast proliferation, and collagen deposited by fibroblastsGeneralized metabolic bone disease in Neurofibromatosis type IMutations in PIK3CA are infrequent in neuroblastoma.Targeted expression of MYCN causes neuroblastoma in transgenic mice.Transposon mutagenesis identifies genes driving hepatocellular carcinoma in a chronic hepatitis B mouse modelAlterations in Notch signaling in neoplastic lesions of the human cervix.The NF1 gene revisited - from bench to bedside.Single cell Ras-GTP analysis reveals altered Ras activity in a subpopulation of neurofibroma Schwann cells but not fibroblasts.Lack of homozygously inactivated p73 in single-copy MYCN primary neuroblastomas and neuroblastoma cell lines.Urinary bladder transitional cell carcinogenesis is associated with down-regulation of NF1 tumor suppressor gene in vivo and in vitro.Retroviral integration at the Evi-2 locus in BXH-2 myeloid leukemia cell lines disrupts Nf1 expression without changes in steady-state Ras-GTP levels.Molecular dissection of isolated disease features in mosaic neurofibromatosis type 1.Pathogenic Mutations in Cancer-Predisposing Genes: A Survey of 300 Patients with Whole-Genome Sequencing and Lifetime Electronic Health Records.Nf1 regulates hematopoietic progenitor cell growth and ras signaling in response to multiple cytokines.The kinesin KIF1Bbeta acts downstream from EglN3 to induce apoptosis and is a potential 1p36 tumor suppressorFunctional evidence for a second tumor suppressor gene on human chromosome 17.Neurofibromin can inhibit Ras-dependent growth by a mechanism independent of its GTPase-accelerating function.NMR-based functional profiling of RASopathies and oncogenic RAS mutations.Neurofibromin 1 (NF1) defects are common in human ovarian serous carcinomas and co-occur with TP53 mutationsExome sequencing identifies recurrent mutations in NF1 and RASopathy genes in sun-exposed melanomas.A retroviral mutagenesis screen reveals strong cooperation between Bcl11a overexpression and loss of the Nf1 tumor suppressor gene.NF1 Mutations Are Common in Desmoplastic Melanoma.The GAP-related domain of neurofibromin attenuates proliferation and downregulates N- and K-Ras activation in Nf1-negative AML cells.Copy number variation in archival melanoma biopsies versus benign melanocytic lesions.Targeting ornithine decarboxylase impairs development of MYCN-amplified neuroblastoma.Combined M-FISH and CGH analysis allows comprehensive description of genetic alterations in neuroblastoma cell lines.NF1-mutated melanoma tumors harbor distinct clinical and biological characteristics.Neurofibromin physically interacts with the N-terminal domain of focal adhesion kinasep53 gene mutations and photocarcinogenesis.Neurofibromatosis type 1: pathology, clinical features and molecular genetics.Synergy between loss of NF1 and overexpression of MYCN in neuroblastoma is mediated by the GAP-related domain.Kinetic mechanisms for overexpression insensitivity and oncogene cooperation.NF1 modulates the effects of Ras oncogenes: evidence of other NF1 function besides its GAP activity.NF1 tumor suppressor mRNA is targeted to the cell-cell contact zone in Ca(2+)-induced keratinocyte differentiation.Extracting Fitness Relationships and Oncogenic Patterns among Driver Genes in Cancer.
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P2860
Inactivation of the NF1 gene in human melanoma and neuroblastoma cell lines without impaired regulation of GTP.Ras
description
1993 nî lūn-bûn
@nan
1993 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1993 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1993年の論文
@ja
1993年論文
@yue
1993年論文
@zh-hant
1993年論文
@zh-hk
1993年論文
@zh-mo
1993年論文
@zh-tw
1993年论文
@wuu
name
Inactivation of the NF1 gene i ...... impaired regulation of GTP.Ras
@ast
Inactivation of the NF1 gene i ...... impaired regulation of GTP.Ras
@en
Inactivation of the NF1 gene i ...... impaired regulation of GTP.Ras
@nl
type
label
Inactivation of the NF1 gene i ...... impaired regulation of GTP.Ras
@ast
Inactivation of the NF1 gene i ...... impaired regulation of GTP.Ras
@en
Inactivation of the NF1 gene i ...... impaired regulation of GTP.Ras
@nl
prefLabel
Inactivation of the NF1 gene i ...... impaired regulation of GTP.Ras
@ast
Inactivation of the NF1 gene i ...... impaired regulation of GTP.Ras
@en
Inactivation of the NF1 gene i ...... impaired regulation of GTP.Ras
@nl
P2093
P2860
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Inactivation of the NF1 gene i ...... impaired regulation of GTP.Ras
@en
P2093
J E DeClue
M B Valentine
M R Johnson
P2860
P304
P3181
P356
10.1073/PNAS.90.12.5539
P407
P577
1993-06-15T00:00:00Z