Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation
about
Oncogenic homeodomain transcription factor E2A-Pbx1 activates a novel WNT gene in pre-B acute lymphoblastoid leukemiaFunctional cloning and characterization of a novel nonhomeodomain protein that inhibits the binding of PBX1-HOX complexes to DNAHuman dipeptidyl-peptidase I. Gene characterization, localization, and expressionStructural determinants within Pbx1 that mediate cooperative DNA binding with pentapeptide-containing Hox proteins: proposal for a model of a Pbx1-Hox-DNA complexThe novel homeoprotein Prep1 modulates Pbx-Hox protein cooperativityMeis1 and pKnox1 bind DNA cooperatively with Pbx1 utilizing an interaction surface disrupted in oncoprotein E2a-Pbx1Critical role for a single leucine residue in leukemia induction by E2A-PBX1Immunocytochemical detection of HoxD9 and Pbx1 homeodomain protein expression in Chinese esophageal squamous cell carcinomasThe pancreatic islet factor STF-1 binds cooperatively with Pbx to a regulatory element in the somatostatin promoter: importance of the FPWMK motif and of the homeodomainMeis proteins are major in vivo DNA binding partners for wild-type but not chimeric Pbx proteinsHigh resolution structure of the HDGF PWWP domain: a potential DNA binding domain.Visualization of protein interactions in living Drosophila embryos by the bimolecular fluorescence complementation assayThe Abd-B-like Hox homeodomain proteins can be subdivided by the ability to form complexes with Pbx1a on a novel DNA target.Expression of zebrafish pax6b in pancreas is regulated by two enhancers containing highly conserved cis-elements bound by PDX1, PBX and PREP factorsSequence conservation and combinatorial complexity of Drosophila neural precursor cell enhancers.Selective repression of transcriptional activators by Pbx1 does not require the homeodomainEB-1, a tyrosine kinase signal transduction gene, is transcriptionally activated in the t(1;19) subset of pre-B ALL, which express oncoprotein E2a-Pbx1.The hexapeptide LFPWMR in Hoxb-8 is required for cooperative DNA binding with Pbx1 and Pbx2 proteins.The role of E2A-PBX1 in leukemogenesis.TdIF1 recognizes a specific DNA sequence through its Helix-Turn-Helix and AT-hook motifs to regulate gene transcription.HOX and non-HOX homeobox genes in leukemic hematopoiesis.E2A-HLF-mediated cell transformation requires both the trans-activation domains of E2A and the leucine zipper dimerization domain of HLF.Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the products of multiple murine Hox genes, some of which are themselves oncogenes.Cooperative interactions between HOX and PBX proteins mediated by a conserved peptide motifPbx modulation of Hox homeodomain amino-terminal arms establishes different DNA-binding specificities across the Hox locus.The Hox cooperativity motif of the chimeric oncoprotein E2a-Pbx1 is necessary and sufficient for oncogenesis.Pbx raises the DNA binding specificity but not the selectivity of antennapedia Hox proteins.Mesodermal expression of the C. elegans HMX homolog mls-2 requires the PBC homolog CEH-20Mechanisms of transcription factor deregulation in lymphoid cell transformation.MyoD and E-protein heterodimers switch rhabdomyosarcoma cells from an arrested myoblast phase to a differentiated state.Transformation by homeobox genes can be mediated by selective transcriptional repression.New insights into transcriptional and leukemogenic mechanisms of AML1-ETO and E2A fusion proteins.Pbx homeodomain proteins: TALEnted regulators of limb patterning and outgrowth.Acute lymphoblastic leukemia and developmental biology: a crucial interrelationshipEnhancer-specific modulation of E protein activity.EVI1 overexpression in distinct subtypes of pediatric acute myeloid leukemia.PKCζ and PKMζ are overexpressed in TCF3-rearranged paediatric acute lymphoblastic leukaemia and are associated with increased thiopurine sensitivity.Pbx-1 Hox heterodimers bind DNA on inseparable half-sites that permit intrinsic DNA binding specificity of the Hox partner at nucleotides 3' to a TAAT motif.The pentapeptide motif of Hox proteins is required for cooperative DNA binding with Pbx1, physically contacts Pbx1, and enhances DNA binding by Pbx1.E2a-Pbx1 induces aberrant expression of tissue-specific and developmentally regulated genes when expressed in NIH 3T3 fibroblasts
P2860
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P2860
Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation
description
1994 nî lūn-bûn
@nan
1994 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի հունիսին հրատարակված գիտական հոդված
@hy
1994年の論文
@ja
1994年論文
@yue
1994年論文
@zh-hant
1994年論文
@zh-hk
1994年論文
@zh-mo
1994年論文
@zh-tw
1994年论文
@wuu
name
Fusion with E2A converts the P ...... ying the t(1;19) translocation
@ast
Fusion with E2A converts the P ...... ying the t(1;19) translocation
@en
Fusion with E2A converts the P ...... ying the t(1;19) translocation
@nl
type
label
Fusion with E2A converts the P ...... ying the t(1;19) translocation
@ast
Fusion with E2A converts the P ...... ying the t(1;19) translocation
@en
Fusion with E2A converts the P ...... ying the t(1;19) translocation
@nl
prefLabel
Fusion with E2A converts the P ...... ying the t(1;19) translocation
@ast
Fusion with E2A converts the P ...... ying the t(1;19) translocation
@en
Fusion with E2A converts the P ...... ying the t(1;19) translocation
@nl
P2093
P2860
P356
P1476
Fusion with E2A converts the P ...... ying the t(1;19) translocation
@en
P2093
P2860
P304
P356
10.1128/MCB.14.6.3938
P407
P577
1994-06-01T00:00:00Z