E2A-HLF-mediated cell transformation requires both the trans-activation domains of E2A and the leucine zipper dimerization domain of HLF.
about
The AD1 and AD2 transactivation domains of E2A are essential for the antiapoptotic activity of the chimeric oncoprotein E2A-HLFCharacterization of the mUBC9-binding sites required for E2A protein degradationDegradation of E2A proteins through a ubiquitin-conjugating enzyme, UbcE2AMurine models of acute leukemia: important tools in current pediatric leukemia research.Disrupted differentiation and oncogenic transformation of lymphoid progenitors in E2A-HLF transgenic miceTwo distinct interleukin-3-mediated signal pathways, Ras-NFIL3 (E4BP4) and Bcl-xL, regulate the survival of murine pro-B lymphocytes.Role for homodimerization in growth deregulation by E2a fusion proteins.CREB is one component of the binding complex of the Ces-2/E2A-HLF binding element and is an integral part of the interleukin-3 survival signal.E2A-HLF usurps control of evolutionarily conserved survival pathways.Restricted expression of E2A protein in primary human tissues correlates with proliferation and differentiation.Conditional Expression of E2A-HLF Induces B-Cell Precursor Death and Myeloproliferative-Like Disease in Knock-In Mice.The AD1 transactivation domain of E2A contains a highly conserved helix which is required for its activity in both Saccharomyces cerevisiae and mammalian cells.Cell transformation mediated by homodimeric E2A-HLF transcription factors.High incidence of T-cell tumors in E2A-null mice and E2A/Id1 double-knockout mice.Mechanisms of transcription factor deregulation in lymphoid cell transformation.Enhancer-specific modulation of E protein activity.Cellular transformation of NIH3T3 fibroblasts by CIZ/NMP4 fusions.Downregulation of Bim, a proapoptotic relative of Bcl-2, is a pivotal step in cytokine-initiated survival signaling in murine hematopoietic progenitorsThe t(8;21) fusion protein, AML1/ETO, transforms NIH3T3 cells and activates AP-1.Identification of Zfp521/ZNF521 as a cooperative gene for E2A-HLF to develop acute B-lineage leukemia.Hypercalcemia in childhood acute lymphoblastic leukemia: frequent implication of parathyroid hormone-related peptide and E2A-HLF from translocation 17;19.
P2860
Q24522770-0BE469D0-A627-4F66-A2E4-A20DB54CDD33Q28144956-3C9D1A77-6C79-41B2-BA13-AAE63E9F28F8Q28566850-C0B3A98D-E760-46C3-9927-1F2E7E7E90A5Q33606018-512DC55D-2B13-4A8F-84E8-73E86BCAB0DBQ33652525-07BD2C84-68B0-47CD-BFD9-2F56F5373BE1Q33957711-0C1433D6-9845-461B-9D9B-177BBEE03E95Q33964971-FAE8B863-97E8-47B0-9548-956ABBB06FF9Q33968736-1C9B989B-C033-4573-BC97-1679B15CB21AQ34405477-EEBEC3C4-455A-4594-BC06-C1F75556BE6CQ35753130-DCBBA43A-E175-44D6-8928-32CCA1D58969Q35847141-C0E4B8BF-C059-41E0-90DC-A269C6698B98Q36556697-0824E79D-D5DB-4964-AA02-6AC0CFF938FFQ36565887-89167F37-999C-4F06-B4D4-F5811C88906DQ36574096-B016C750-410A-4776-8E73-C2AF5A55FD7AQ36970219-3456FB9E-57CD-4303-8A1A-FFBF7BD0632EQ38294388-85B0C5A8-4B6D-475A-B79B-B1F39A5C9CD9Q38331471-AAB84A8B-FE3E-45D3-96F7-3C925A7ECE19Q39457731-DDDA6C96-BE28-48DC-9FDB-266B560539FAQ42816817-BA244F18-2CCC-4EEC-9B17-47D4ECA1D836Q51918384-69E2D8B3-B2B8-4F25-A091-B25D4E43D0A4Q54566038-90FEF624-DD68-4790-901E-0ACFEC1F0DB3
P2860
E2A-HLF-mediated cell transformation requires both the trans-activation domains of E2A and the leucine zipper dimerization domain of HLF.
description
1995 nî lūn-bûn
@nan
1995年の論文
@ja
1995年論文
@yue
1995年論文
@zh-hant
1995年論文
@zh-hk
1995年論文
@zh-mo
1995年論文
@zh-tw
1995年论文
@wuu
1995年论文
@zh
1995年论文
@zh-cn
name
E2A-HLF-mediated cell transfor ...... er dimerization domain of HLF.
@ast
E2A-HLF-mediated cell transfor ...... er dimerization domain of HLF.
@en
type
label
E2A-HLF-mediated cell transfor ...... er dimerization domain of HLF.
@ast
E2A-HLF-mediated cell transfor ...... er dimerization domain of HLF.
@en
prefLabel
E2A-HLF-mediated cell transfor ...... er dimerization domain of HLF.
@ast
E2A-HLF-mediated cell transfor ...... er dimerization domain of HLF.
@en
P2093
P2860
P356
P1476
E2A-HLF-mediated cell transfor ...... er dimerization domain of HLF.
@en
P2093
P2860
P304
P356
10.1128/MCB.15.6.3247
P407
P577
1995-06-01T00:00:00Z