Small molecules that enhance the catalytic efficiency of HLA-DM
about
Human leukocyte Antigen-DM polymorphisms in autoimmune diseasesA step-by-step overview of the dynamic process of epitope selection by major histocompatibility complex class II for presentation to helper T cellsMHC Class II Auto-Antigen Presentation is UnconventionalHLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanismCrystal Structure of the HLA-DM–HLA-DR1 Complex Defines Mechanisms for Rapid Peptide SelectionDisruption of Hydrogen Bonds between Major Histocompatibility Complex Class II and the Peptide N-Terminus Is Not Sufficient to Form a Human Leukocyte Antigen-DM Receptive State of Major Histocompatibility Complex Class IIEnhancement of tumour-specific immune responses in vivo by 'MHC loading-enhancer' (MLE)Small organic compounds enhance antigen loading of class II major histocompatibility complex proteins by targeting the polymorphic P1 pocket.HLA-DM captures partially empty HLA-DR molecules for catalyzed removal of peptideHLA-DM mediates epitope selection by a "compare-exchange" mechanism when a potential peptide pool is available.Structure-based selection of small molecules to alter allele-specific MHC class II antigen presentationDivergent paths for the selection of immunodominant epitopes from distinct antigenic sources.Dipeptides catalyze rapid peptide exchange on MHC class I moleculesSelf-reactive human CD4 T cell clones form unusual immunological synapsesEvaluating the Role of HLA-DM in MHC Class II-Peptide Association Reactions.Empty class II major histocompatibility complex created by peptide photolysis establishes the role of DM in peptide association.In vivo enhancement of peptide display by MHC class II molecules with small molecule catalysts of peptide exchange.Candidate genes involved in beneficial or adverse responses to commonly eaten brassica vegetables in a New Zealand Crohn's disease cohort.Gamma-IFN-inducible-lysosomal thiol reductase modulates acidic proteases and HLA class II antigen processing in melanoma.Conformational variation in structures of classical and non-classical MHCII proteins and functional implications.Targeting the MHC Class II antigen presentation pathway in cancer immunotherapy.HLA-DM and HLA-DO, key regulators of MHC-II processing and presentation.Measurement of Peptide Binding to MHC Class II Molecules by Fluorescence Polarization.Mechanistic understanding and significance of small peptides interaction with MHC class II molecules for therapeutic applications.A novel method to measure HLA-DM-susceptibility of peptides bound to MHC class II molecules based on peptide binding competition assay and differential IC(50) determination.Induction of apoptosis and immune response by all-trans retinoic acid plus interferon-gamma in human malignant glioblastoma T98G and U87MG cells.Flexibility of the MHC class II peptide binding cleft in the bound, partially filled, and empty states: a molecular dynamics simulation study.
P2860
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P2860
Small molecules that enhance the catalytic efficiency of HLA-DM
description
2006 nî lūn-bûn
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2006 թուականի Ապրիլին հրատարակուած գիտական յօդուած
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2006 թվականի ապրիլին հրատարակված գիտական հոդված
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2006年の論文
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2006年論文
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2006年論文
@zh-hant
2006年論文
@zh-hk
2006年論文
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2006年論文
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2006年论文
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name
Small molecules that enhance the catalytic efficiency of HLA-DM
@ast
Small molecules that enhance the catalytic efficiency of HLA-DM
@en
Small molecules that enhance the catalytic efficiency of HLA-DM
@nl
type
label
Small molecules that enhance the catalytic efficiency of HLA-DM
@ast
Small molecules that enhance the catalytic efficiency of HLA-DM
@en
Small molecules that enhance the catalytic efficiency of HLA-DM
@nl
prefLabel
Small molecules that enhance the catalytic efficiency of HLA-DM
@ast
Small molecules that enhance the catalytic efficiency of HLA-DM
@en
Small molecules that enhance the catalytic efficiency of HLA-DM
@nl
P2093
P2860
P3181
P1476
Small molecules that enhance the catalytic efficiency of HLA-DM
@en
P2093
Babak Moradi
Gregory D Cuny
Kai W Wucherpfennig
Melissa J Nicholson
Nilufer P Seth
Ross L Stein
Xuechao Xing
P2860
P304
P3181
P356
10.4049/JIMMUNOL.176.7.4208
P407
P577
2006-04-01T00:00:00Z