HLA-DM mediates epitope selection by a "compare-exchange" mechanism when a potential peptide pool is available.
about
A step-by-step overview of the dynamic process of epitope selection by major histocompatibility complex class II for presentation to helper T cellsHLA-DO acts as a substrate mimic to inhibit HLA-DM by a competitive mechanismConformational lability in the class II MHC 310 helix and adjacent extended strand dictate HLA-DM susceptibility and peptide exchangeSusceptibility to HLA-DM Protein Is Determined by a Dynamic Conformation of Major Histocompatibility Complex Class II Molecule Bound with PeptideEvaluating the Role of HLA-DM in MHC Class II-Peptide Association Reactions.The Thermodynamic Mechanism of Peptide-MHC Class II Complex Formation Is a Determinant of Susceptibility to HLA-DM.HLA-DM constrains epitope selection in the human CD4 T cell response to vaccinia virus by favoring the presentation of peptides with longer HLA-DM-mediated half-livesThermodynamics of Peptide-MHC Class II Interactions: Not all Complexes are Created Equal.Conformational variation in structures of classical and non-classical MHCII proteins and functional implications.HLA-DM: arbiter conformationis.HLA-DM Focuses on Conformational Flexibility Around P1 Pocket to Catalyze Peptide Exchange.HLA-DM and HLA-DO, key regulators of MHC-II processing and presentation.Measurement of Peptide Binding to MHC Class II Molecules by Fluorescence Polarization.Structural Insights Into HLA-DM Mediated MHC II Peptide Exchange.DM influences the abundance of major histocompatibility complex class II alleles with low affinity for class II-associated invariant chain peptides via multiple mechanisms.A novel method to measure HLA-DM-susceptibility of peptides bound to MHC class II molecules based on peptide binding competition assay and differential IC(50) determination.Characterization of desmoglein-3 epitope region peptides as synthetic antigens: analysis of their in vitro T cell stimulating efficacy, cytotoxicity, stability, and their conformational features.A Peptide/MHCII conformer generated in the presence of exchange peptide is substrate for HLA-DM editing.
P2860
Q26747063-4759A932-B2DF-4BF8-B27A-B004C8023D93Q27675409-1DCED3F0-75BA-4560-B030-D8D8C0335C40Q27675571-85D944D8-7A9C-4A0D-B60B-5757290968A1Q27684590-414373D9-36DD-4440-8517-9DC0D088F6E7Q35815584-DCCC3283-4A4F-44F1-BADC-676AE6AD6222Q35861946-C4622EDA-21A2-4064-9A33-F9458D6D3741Q36303660-8AE7B46A-8B00-4D15-BF78-C309066DCAE2Q37208000-23117D97-8DC4-42AE-8376-E39D1F58171AQ38050482-95B1AE72-72D2-41F1-8365-D1EA7A284098Q38056763-A7D64196-8564-44A8-9BEB-97475BA9D51FQ38154571-4A0A7B9D-EEE8-4CCA-93D3-4CE7D3171011Q38181859-71F94CE3-A822-4CA7-A7AC-F63C89923992Q38235847-37593A77-1C03-4C9E-8C6A-07FD108BF826Q38255165-8024899A-E6AE-49F9-9073-7F349A5FC36AQ39712353-1E539152-D7FC-4CA8-862D-5B6ABD30CA1EQ39843966-FA6EA64C-0842-47F4-80FB-2F00DDFD4DB6Q40650057-2AEC8159-3D85-432C-AC26-154790D44DCFQ42015843-2900580F-CA8C-47A4-AC5B-962DBE7C8DA2
P2860
HLA-DM mediates epitope selection by a "compare-exchange" mechanism when a potential peptide pool is available.
description
2008 nî lūn-bûn
@nan
2008 թուականի Նոյեմբերին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի նոյեմբերին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
HLA-DM mediates epitope select ...... ial peptide pool is available.
@ast
HLA-DM mediates epitope select ...... ial peptide pool is available.
@en
type
label
HLA-DM mediates epitope select ...... ial peptide pool is available.
@ast
HLA-DM mediates epitope select ...... ial peptide pool is available.
@en
prefLabel
HLA-DM mediates epitope select ...... ial peptide pool is available.
@ast
HLA-DM mediates epitope select ...... ial peptide pool is available.
@en
P2093
P2860
P1433
P1476
HLA-DM mediates epitope select ...... ial peptide pool is available.
@en
P2093
Andrea Ferrante
Candice S Klug
Jack Gorski
Matthew W Anderson
P2860
P356
10.1371/JOURNAL.PONE.0003722
P407
P577
2008-11-13T00:00:00Z