Insights into the structure, function and evolution of the radical-SAM 23S rRNA methyltransferase Cfr that confers antibiotic resistance in bacteria - Wikidata - wikimedia - TriplyDB

Insights into the structure, function and evolution of the radical-SAM 23S rRNA methyltransferase Cfr that confers antibiotic resistance in bacteria

Insights into the structure, function and evolution of the radical-SAM 23S rRNA methyltransferase Cfr that confers antibiotic resistance in bacteria

http://www.wikidata.org/entity/Q24630132

about

Mechanistic and functional versatility of radical SAM enzymes RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA Resistance to linezolid caused by modifications at its binding site on the ribosome Radical SAM-mediated methylation reactions Structural Basis for Methyl Transfer by a Radical SAM Enzyme Characterization of a Cross-Linked Protein–Nucleic Acid Substrate Radical in the Reaction Catalyzed by RlmN Discovery of the β-barrel-type RNA methyltransferase responsible for N6-methylation of N6-threonylcarbamoyladenosine in tRNAs Biochemical and Computational Analysis of the Substrate Specificities of Cfr and RlmN Methyltransferases Radical SAM enzymes in methylation and methylthiolation Genome mining for radical SAM protein determinants reveals multiple sactibiotic-like gene clusters.New archaeal methyltransferases forming 1-methyladenosine or 1-methyladenosine and 1-methylguanosine at position 9 of tRNA.A radically different mechanism for S-adenosylmethionine-dependent methyltransferases.Mechanistic diversity of radical S-adenosylmethionine (SAM)-dependent methylation.Low fitness cost of the multidrug resistance gene cfr.Transferable plasmid-mediated resistance to linezolid due to cfr in a human clinical isolate of Enterococcus faecalis The order Bacillales hosts functional homologs of the worrisome cfr antibiotic resistance gene Predictive computational phenotyping and biomarker discovery using reference-free genome comparisons.The Escherichia coli RlmN methyltransferase is a dual-specificity enzyme that modifies both rRNA and tRNA and controls translational accuracy.Covalent intermediate in the catalytic mechanism of the radical S-adenosyl-L-methionine methyl synthase RlmN trapped by mutagenesis.Transferable multiresistance plasmids carrying cfr in Enterococcus spp. from swine and farm environment.Cfr and RlmN contain a single [4Fe-4S] cluster, which directs two distinct reactivities for S-adenosylmethionine: methyl transfer by SN2 displacement and radical generation.Dissecting the mechanisms of linezolid resistance in a Drosophila melanogaster infection model of Staphylococcus aureus.Antibiotic resistance evolved via inactivation of a ribosomal RNA methylating enzyme.Radical S-adenosylmethionine enzymes.Emergence and spread of cfr-mediated multiresistance in staphylococci: an interdisciplinary challenge.The oxazolidinones: past, present, and future.The chemistry of peptidyltransferase center-targeted antibiotics: enzymatic resistance and approaches to countering resistance.Protein and nucleic acid methylating enzymes: mechanisms and regulation Transfer RNA methyltransferases with a SpoU-TrmD (SPOUT) fold and their modified nucleosides in tRNA.Insight from the draft genome of Dietzia cinnamea P4 reveals mechanisms of survival in complex tropical soil habitats and biotechnology potential.Detection of a New cfr-Like Gene, cfr(B), in Enterococcus faecium Isolates Recovered from Human Specimens in the United States as Part of the SENTRY Antimicrobial Surveillance Program.Molecular characterization of linezolid-resistant CoNS isolates in Japan.Distinction between the Cfr methyltransferase conferring antibiotic resistance and the housekeeping RlmN methyltransferase.A substrate radical intermediate in catalysis by the antibiotic resistance protein Cfr.Nomenclature and functionality of the so-called cfr gene from Clostridium difficile.S-Adenosylmethionine Synthetase 3 Is Important for Pollen Tube Growth.Structural and functional characterization of the TYW3/Taw3 class of SAM-dependent methyltransferases.Emergence of a plasmid-borne multidrug resistance gene cfr(C) in foodborne pathogen Campylobacter.

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Insights into the structure, function and evolution of the radical-SAM 23S rRNA methyltransferase Cfr that confers antibiotic resistance in bacteria

http://www.wikidata.org/entity/Q24630132

description

2010 nî lūn-bûn

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2010 թուականի Մարտին հրատարակուած գիտական յօդուած

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2010 թվականի մարտին հրատարակված գիտական հոդված

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2010年の論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年論文

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2010年论文

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name

Insights into the structure, f ...... ibiotic resistance in bacteria

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Insights into the structure, f ...... ibiotic resistance in bacteria

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Insights into the structure, f ...... ibiotic resistance in bacteria

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Insights into the structure, f ...... ibiotic resistance in bacteria

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Insights into the structure, f ...... ibiotic resistance in bacteria

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Insights into the structure, f ...... ibiotic resistance in bacteria

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Insights into the structure, f ...... ibiotic resistance in bacteria

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Insights into the structure, f ...... ibiotic resistance in bacteria

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Nucleic Acids Research

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Insights into the structure, f ...... ibiotic resistance in bacteria

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Birte Vester

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Elzbieta Purta

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Katarzyna H Kaminska

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Katherine S Long

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Lykke H Hansen

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P2860

Construction of Escherichia coli K-12 in-frame, single-gene knockout mutants: the Keio collection

Gapped BLAST and PSI-BLAST: a new generation of protein database search programs

Electrostatics of nanosystems: application to microtubules and the ribosome

MUSCLE: multiple sequence alignment with high accuracy and high throughput

Radical SAM, a novel protein superfamily linking unresolved steps in familiar biosynthetic pathways with radical mechanisms: functional characterization using new analysis and information visualization methods

Identification of 8-methyladenosine as the modification catalyzed by the radical SAM methyltransferase Cfr that confers antibiotic resistance in bacteria

WoLF PSORT: protein localization predictor

The methyltransferase YfgB/RlmN is responsible for modification of adenosine 2503 in 23S rRNA

ConSurf 2005: the projection of evolutionary conservation scores of residues on protein structures

Natural history of S-adenosylmethionine-binding proteins

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1652-63

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3341511

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10.1093/NAR/GKP1142

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P433

5

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38

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Janusz Bujnicki

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2010-03-01T00:00:00Z

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40685363

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20007606

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rRNA (adenine-C2-)-methyltransferase activity

antibiotic resistance

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2836569

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