Cfr and RlmN contain a single [4Fe-4S] cluster, which directs two distinct reactivities for S-adenosylmethionine: methyl transfer by SN2 displacement and radical generation.
about
Radical SAM-mediated methylation reactionsCharacterization of a Cross-Linked Protein–Nucleic Acid Substrate Radical in the Reaction Catalyzed by RlmNCrystallographic capture of a radical S-adenosylmethionine enzyme in the act of modifying tRNAPhosphorylation of Elp1 by Hrr25 is required for elongator-dependent tRNA modification in yeast.Biochemical and Computational Analysis of the Substrate Specificities of Cfr and RlmN Methyltransferases7-Carboxy-7-deazaguanine Synthase: A Radical S-Adenosyl-l-methionine Enzyme with Polar TendenciesRadical SAM enzymes in methylation and methylthiolationEmerging themes in radical SAM chemistryIdentification of a unique radical S-adenosylmethionine methylase likely involved in methanopterin biosynthesis in Methanocaldococcus jannaschii.Recent advances in radical SAM enzymology: new structures and mechanisms.Mechanistic diversity of radical S-adenosylmethionine (SAM)-dependent methylation.Consecutive radical S-adenosylmethionine methylations form the ethyl side chain in thienamycin biosynthesisThe order Bacillales hosts functional homologs of the worrisome cfr antibiotic resistance geneDeterminants of tRNA Recognition by the Radical SAM Enzyme RlmN.Covalent intermediate in the catalytic mechanism of the radical S-adenosyl-L-methionine methyl synthase RlmN trapped by mutagenesis.Structural diversity in the AdoMet radical enzyme superfamily.Biochemical and Spectroscopic Studies of Epoxyqueuosine Reductase: A Novel Iron-Sulfur Cluster- and Cobalamin-Containing Protein Involved in the Biosynthesis of Queuosine.Cysteine methylation controls radical generation in the Cfr radical AdoMet rRNA methyltransferaseOn the Role of Additional [4Fe-4S] Clusters with a Free Coordination Site in Radical-SAM Enzymes.Radical S-adenosylmethionine enzymes.The chemistry of peptidyltransferase center-targeted antibiotics: enzymatic resistance and approaches to countering resistance.Substrate-Dependent Cleavage Site Selection by Unconventional Radical S-Adenosylmethionine Enzymes in Diphthamide Biosynthesis.Identification of an intermediate methyl carrier in the radical S-adenosylmethionine methylthiotransferases RimO and MiaB.Distinction between the Cfr methyltransferase conferring antibiotic resistance and the housekeeping RlmN methyltransferase.A substrate radical intermediate in catalysis by the antibiotic resistance protein Cfr.Hydrogen transfer in SAM-mediated enzymatic radical reactions.Systematic Proteomic Analysis of Protein Methylation in Prokaryotes and Eukaryotes Revealed Distinct Substrate Specificity.A QM/MM study of the catalytic mechanism of SAM methyltransferase RlmN from Escherichia coli.The mechanisms of radical SAM/cobalamin methylations: an evolving working hypothesis.X-ray and EPR Characterization of the Auxiliary Fe-S Clusters in the Radical SAM Enzyme PqqE.
P2860
Q27011761-D2A992A2-1C46-4F57-88BF-66D1A7026A87Q27683674-708CD37F-C40E-484F-8E2E-4B7253C1E0FDQ27704575-A5C71181-A69A-4567-A04F-F8DF392A0CCEQ27930355-DFB05C53-C4D2-4DB0-81E9-E492790336D8Q28551755-527DCB2A-2699-43B4-AE6F-2DB4EF224E06Q28817051-7FD58253-2F78-441D-B5ED-1B3B3831FB13Q33575267-85A0885E-3FC0-4243-A951-222AED989A76Q33851840-2C0D534A-9969-4E6C-A7B3-89ECEE01C3D0Q34056857-74A23B93-3468-4212-9ADF-5907AFCD36B3Q34211575-BA23558A-E511-4C37-8E59-5985C7C6AFE6Q35080231-FC6B0F3F-2959-4058-A780-0237E5D9D17FQ35990000-A07EA700-F1EE-4BDE-85A9-76E50FBAF26BQ36086450-E5C92D4E-813B-49CF-BAE3-52CFF743CF76Q36208300-26FBE6DF-3267-4ADD-A9FB-F1FC1E938F46Q36402114-3BF0F63D-DE1C-43D5-AF60-626DA0C4BF3CQ36469251-E0DC1C1A-0A2C-4B4F-85F7-9812BE680FE7Q36578579-80A4E482-4F90-4D79-B971-C465EFCB3E81Q36986036-6291936B-BFD7-4A1B-9D1C-D4341E2C7BF1Q37703125-4F648123-BEB7-44D6-9454-1A10E58B8925Q37727698-9B638971-B413-4911-9978-5A291BE749B6Q37972308-53CE971E-D102-45C3-9A9B-FF18A19C9A47Q38850246-376D0541-7C1C-4B84-B927-70FB81C8CAB5Q39677839-03317738-31DC-4850-A2DA-0728E0DE30EBQ41774206-7EAAE445-4A0B-49E5-B367-D161276B86A2Q41881947-7A7AD02F-B3B2-4991-85B3-66B61E73C536Q44379183-45F2B7E1-6EA5-43FA-BCA9-FB3BA0179C74Q46259123-76F6E322-B1A1-4005-B9C0-265B4EFC6F01Q46345706-80048201-D385-4D3B-9C0F-D59C9127BAE8Q46389204-7A2AFA8E-7DF2-46B2-A4BF-3F5412B1D67BQ48098700-C0CD254F-F39A-4791-9566-7BB7BAB071CE
P2860
Cfr and RlmN contain a single [4Fe-4S] cluster, which directs two distinct reactivities for S-adenosylmethionine: methyl transfer by SN2 displacement and radical generation.
description
2011 nî lūn-bûn
@nan
2011年の論文
@ja
2011年論文
@yue
2011年論文
@zh-hant
2011年論文
@zh-hk
2011年論文
@zh-mo
2011年論文
@zh-tw
2011年论文
@wuu
2011年论文
@zh
2011年论文
@zh-cn
name
Cfr and RlmN contain a single ...... cement and radical generation.
@ast
Cfr and RlmN contain a single ...... cement and radical generation.
@en
type
label
Cfr and RlmN contain a single ...... cement and radical generation.
@ast
Cfr and RlmN contain a single ...... cement and radical generation.
@en
prefLabel
Cfr and RlmN contain a single ...... cement and radical generation.
@ast
Cfr and RlmN contain a single ...... cement and radical generation.
@en
P2093
P2860
P356
P1476
Cfr and RlmN contain a single ...... cement and radical generation.
@en
P2093
Matthew I Radle
Squire J Booker
Tyler L Grove
P2860
P304
19586-19589
P356
10.1021/JA207327V
P407
P577
2011-11-18T00:00:00Z