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Structural Basis for Methyl Transfer by a Radical SAM Enzyme

Structural Basis for Methyl Transfer by a Radical SAM Enzyme

http://www.wikidata.org/entity/Q27667611

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The methylthiolation reaction mediated by the Radical-SAM enzymes Spore photoproduct lyase: the known, the controversial, and the unknown Resistance to linezolid caused by modifications at its binding site on the ribosome Radical SAM-mediated methylation reactions Radical-mediated enzymatic methylation: a tale of two SAMS Protein methylation at the surface and buried deep: thinking outside the histone box Nitrogenase assembly Structural insights into recognition and repair of UV-DNA damage by Spore Photoproduct Lyase, a radical SAM enzyme Protein cysteine phosphorylation of SarA/MgrA family transcriptional regulators mediates bacterial virulence and antibiotic resistance Characterization of a Cross-Linked Protein–Nucleic Acid Substrate Radical in the Reaction Catalyzed by RlmN Crystallographic capture of a radical S-adenosylmethionine enzyme in the act of modifying tRNA The Many Faces of Elongator in Neurodevelopment and Disease Structure and specificity of the bacterial cysteine methyltransferase effector NleE suggests a novel substrate in human DNA repair pathway Biochemical and Computational Analysis of the Substrate Specificities of Cfr and RlmN Methyltransferases Novel modifications in RNA 7-Carboxy-7-deazaguanine Synthase: A Radical S-Adenosyl-l-methionine Enzyme with Polar Tendencies Structural basis for tRNA modification by Elp3 from Dehalococcoides mccartyi.Biosynthesis of nitrogenase metalloclusters.Radical SAM enzymes in methylation and methylthiolation Lost in Translation: Defects in Transfer RNA Modifications and Neurological Disorders.Glycyl radical activating enzymes: structure, mechanism, and substrate interactions Emerging themes in radical SAM chemistry Evolutionary and sequence-based relationships in bacterial AdoMet-dependent non-coding RNA methyltransferases A journey into the active center of nitrogenase Identification of a unique radical S-adenosylmethionine methylase likely involved in methanopterin biosynthesis in Methanocaldococcus jannaschii.Paramagnetic intermediates generated by radical S-adenosylmethionine (SAM) enzymes Recent advances in radical SAM enzymology: new structures and mechanisms.Profound methyl effects in drug discovery and a call for new C-H methylation reactions.Mechanistic diversity of radical S-adenosylmethionine (SAM)-dependent methylation.Complex biotransformations catalyzed by radical S-adenosylmethionine enzymes.S-adenosylmethionine blocks osteosarcoma cells proliferation and invasion in vitro and tumor metastasis in vivo: therapeutic and diagnostic clinical applications The order Bacillales hosts functional homologs of the worrisome cfr antibiotic resistance gene Determinants of tRNA Recognition by the Radical SAM Enzyme RlmN.Identification and characterization of functional homologs of nitrogenase cofactor biosynthesis protein NifB from methanogens.Covalent intermediate in the catalytic mechanism of the radical S-adenosyl-L-methionine methyl synthase RlmN trapped by mutagenesis.Structural diversity in the AdoMet radical enzyme superfamily.Cfr and RlmN contain a single [4Fe-4S] cluster, which directs two distinct reactivities for S-adenosylmethionine: methyl transfer by SN2 displacement and radical generation.Revealing nature's synthetic potential through the study of ribosomal natural product biosynthesis.Elongator: transcriptional or translational regulator?Cysteine methylation controls radical generation in the Cfr radical AdoMet rRNA methyltransferase

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Structural Basis for Methyl Transfer by a Radical SAM Enzyme

http://www.wikidata.org/entity/Q27667611

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2011 nî lūn-bûn

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2011 թուականի Մայիսին հրատարակուած գիտական յօդուած

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2011 թվականի մայիսին հրատարակված գիտական հոդված

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2011年の論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年論文

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2011年论文

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name

Structural Basis for Methyl Transfer by a Radical SAM Enzyme

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Structural Basis for Methyl Transfer by a Radical SAM Enzyme

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Structural Basis for Methyl Transfer by a Radical SAM Enzyme

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Structural Basis for Methyl Transfer by a Radical SAM Enzyme

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Structural Basis for Methyl Transfer by a Radical SAM Enzyme

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Structural Basis for Methyl Transfer by a Radical SAM Enzyme

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Structural Basis for Methyl Transfer by a Radical SAM Enzyme

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Structural Basis for Methyl Transfer by a Radical SAM Enzyme

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Structural Basis for Methyl Transfer by a Radical SAM Enzyme

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Structural basis for methyl transfer by a radical SAM enzyme

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Amie K Boal

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Amy C Rosenzweig

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Neela H Yennawar

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Squire J Booker

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Tyler L Grove

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P2860

Crystal structure of biotin synthase, an S-adenosylmethionine-dependent radical enzyme

Electrostatics of nanosystems: application to microtubules and the ribosome

RNA methylation by radical SAM enzymes RlmN and Cfr proceeds via methylene transfer and hydride shift

Radical SAM, a novel protein superfamily linking unresolved steps in familiar biosynthetic pathways with radical mechanisms: functional characterization using new analysis and information visualization methods

Insights into the structure, function and evolution of the radical-SAM 23S rRNA methyltransferase Cfr that confers antibiotic resistance in bacteria

RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA

Fine-tuning of the ribosomal decoding center by conserved methyl-modifications in the Escherichia coli 16S rRNA

Crystal structure of coproporphyrinogen III oxidase reveals cofactor geometry of Radical SAM enzymes

Identification of 8-methyladenosine as the modification catalyzed by the radical SAM methyltransferase Cfr that confers antibiotic resistance in bacteria

The methyltransferase YfgB/RlmN is responsible for modification of adenosine 2503 in 23S rRNA

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2713300

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10.1126/SCIENCE.1205358

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6033

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332

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Monica I McLaughlin

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2011-04-28T00:00:00Z

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51084219

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21527678

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rRNA (adenine-C2-)-methyltransferase activity

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3506250

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