Identification of 8-methyladenosine as the modification catalyzed by the radical SAM methyltransferase Cfr that confers antibiotic resistance in bacteria - Wikidata - wikimedia - TriplyDB

Identification of 8-methyladenosine as the modification catalyzed by the radical SAM methyltransferase Cfr that confers antibiotic resistance in bacteria

Identification of 8-methyladenosine as the modification catalyzed by the radical SAM methyltransferase Cfr that confers antibiotic resistance in bacteria

http://www.wikidata.org/entity/Q24647451

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RNA methylation by radical SAM enzymes RlmN and Cfr proceeds via methylene transfer and hydride shift Insights into the structure, function and evolution of the radical-SAM 23S rRNA methyltransferase Cfr that confers antibiotic resistance in bacteria Mechanistic and functional versatility of radical SAM enzymes RlmN and Cfr are radical SAM enzymes involved in methylation of ribosomal RNA Chloramphenicol Derivatives as Antibacterial and Anticancer Agents: Historic Problems and Current Solutions Resistance to linezolid caused by modifications at its binding site on the ribosome Radical SAM-mediated methylation reactions Structural Basis for Methyl Transfer by a Radical SAM Enzyme Crystal structure of RlmM, the 2'O-ribose methyltransferase for C2498 of Escherichia coli 23S rRNA Characterization of a Cross-Linked Protein–Nucleic Acid Substrate Radical in the Reaction Catalyzed by RlmN Crystallographic capture of a radical S-adenosylmethionine enzyme in the act of modifying tRNA MODOMICS: a database of RNA modification pathways--2013 update The RNA Modification Database, RNAMDB: 2011 update A single methyltransferase YefA (RlmCD) catalyses both m5U747 and m5U1939 modifications in Bacillus subtilis 23S rRNA Synthesis and evaluation of chloramphenicol homodimers: molecular target, antimicrobial activity, and toxicity against human cells Biochemical and Computational Analysis of the Substrate Specificities of Cfr and RlmN Methyltransferases Novel modifications in RNA First Report of cfr-Carrying Plasmids in the Pandemic Sequence Type 22 Methicillin-Resistant Staphylococcus aureus Staphylococcal Cassette Chromosome mec Type IV Clone.Radical SAM enzymes in methylation and methylthiolation Understanding RNA modifications: the promises and technological bottlenecks of the 'epitranscriptome'.The flavoprotein Mcap0476 (RlmFO) catalyzes m5U1939 modification in Mycoplasma capricolum 23S rRNA.3-(3-amino-3-carboxypropyl)-5,6-dihydrouridine is one of two novel post-transcriptional modifications in tRNALys(UUU) from Trypanosoma brucei.The key function of a conserved and modified rRNA residue in the ribosomal response to the nascent peptide.A radically different mechanism for S-adenosylmethionine-dependent methyltransferases.Mutations in 23S rRNA at the peptidyl transferase center and their relationship to linezolid binding and cross-resistance.Inactivation of the indigenous methyltransferase RlmN in Staphylococcus aureus increases linezolid resistance Mechanistic diversity of radical S-adenosylmethionine (SAM)-dependent methylation.Low fitness cost of the multidrug resistance gene cfr.A cfr-like gene from Clostridium difficile confers multiple antibiotic resistance by the same mechanism as the cfr gene The order Bacillales hosts functional homologs of the worrisome cfr antibiotic resistance gene The Escherichia coli RlmN methyltransferase is a dual-specificity enzyme that modifies both rRNA and tRNA and controls translational accuracy.A Platform for Discovery and Quantification of Modified Ribonucleosides in RNA: Application to Stress-Induced Reprogramming of tRNA Modifications.The genetic environment of the cfr gene and the presence of other mechanisms account for the very high linezolid resistance of Staphylococcus epidermidis isolate 426-3147L Cfr and RlmN contain a single [4Fe-4S] cluster, which directs two distinct reactivities for S-adenosylmethionine: methyl transfer by SN2 displacement and radical generation.Cysteine methylation controls radical generation in the Cfr radical AdoMet rRNA methyltransferase Antibiotic resistance evolved via inactivation of a ribosomal RNA methylating enzyme.Distribution of cfr in Staphylococcus spp. and Escherichia coli Strains from Pig Farms in China and Characterization of a Novel cfr-Carrying F43:A-:B- Plasmid Radical S-adenosylmethionine enzymes.S-Adenosylmethionine-dependent alkylation reactions: when are radical reactions used?RNA nucleotide methylation.

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Identification of 8-methyladenosine as the modification catalyzed by the radical SAM methyltransferase Cfr that confers antibiotic resistance in bacteria

http://www.wikidata.org/entity/Q24647451

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2009 nî lūn-bûn

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2009 թուականի Փետրուարին հրատարակուած գիտական յօդուած

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2009 թվականի փետրվարին հրատարակված գիտական հոդված

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2009年の論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年論文

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2009年论文

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Identification of 8-methyladen ...... ibiotic resistance in bacteria

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Identification of 8-methyladen ...... ibiotic resistance in bacteria

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Identification of 8-methyladen ...... ibiotic resistance in bacteria

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Anders Michael Bernth Giessing

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Andrzej Gondela

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Anette Rasmussen

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Finn Kirpekar

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Katherine Long

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Lykke Haastrup Hansen

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Søren Skov Jensen

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P2860

Radical SAM, a novel protein superfamily linking unresolved steps in familiar biosynthetic pathways with radical mechanisms: functional characterization using new analysis and information visualization methods

The oxazolidinone antibiotics perturb the ribosomal peptidyl-transferase center and effect tRNA positioning

The methyltransferase YfgB/RlmN is responsible for modification of adenosine 2503 in 23S rRNA

Structural basis for the interaction of antibiotics with the peptidyl transferase centre in eubacteria

Translational regulation via L11: molecular switches on the ribosome turned on and off by thiostrepton and micrococcin

Crystal structure of the oxazolidinone antibiotic linezolid bound to the 50S ribosomal subunit

Capreomycin binds across the ribosomal subunit interface using tlyA-encoded 2'-O-methylations in 16S and 23S rRNAs

Study of the mass spectrometric fragmentation of pseudouridine: comparison of fragmentation data obtained by matrix-assisted laser desorption/ionisation post-source decay, electrospray ion trap multistage mass spectrometry, and by a method utilising

A novel partial modification at C2501 in Escherichia coli 23S ribosomal RNA

Recent developments in mass spectrometry for the characterization of nucleosides, nucleotides, oligonucleotides, and nucleic acids.

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10.1261/RNA.1371409

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2

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23789004

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19144912

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antibiotic resistance

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