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The sugar ring of the nucleoside is required for productive substrate positioning in the active site of human deoxycytidine kinase (dCK): implications for the development of dCK-activated acyclic guanine analoguesPost-translational phosphorylation of serine 74 of human deoxycytidine kinase favors the enzyme adopting the open conformation making it competent for nucleoside binding and releaseStructural and kinetic characterization of human deoxycytidine kinase variants able to phosphorylate 5-substituted deoxycytidine and thymidine analoguesElucidation of different binding modes of purine nucleosides to human deoxycytidine kinaseDevelopment of New Deoxycytidine Kinase Inhibitors and Noninvasive in Vivo Evaluation Using Positron Emission TomographyStructural characterization of new deoxycytidine kinase inhibitors rationalizes the affinity-determining moieties of the moleculesRetrovolution: HIV-driven evolution of cellular genes and improvement of anticancer drug activationStructure-guided development of deoxycytidine kinase inhibitors with nanomolar affinity and improved metabolic stability.Phosphorylation of nucleoside-metallacarborane and carborane conjugates by nucleoside kinases.Novel PET probes specific for deoxycytidine kinase.The contribution of CMP kinase to the efficiency of DNA repairCell fate control gene therapy based on engineered variants of human deoxycytidine kinaseNucleoside salvage pathway kinases regulate hematopoiesis by linking nucleotide metabolism with replication stress.[18F]CFA as a clinically translatable probe for PET imaging of deoxycytidine kinase activity.Bromopyridone Nucleotide Analogues, Anoxic Selective Radiosensitizing Agents That Are Incorporated in DNA by Polymerases.Inhibition of dengue virus RNA synthesis by an adenosine nucleoside.Understanding the role of structural integrity and differential expression of integrin profiling to identify potential therapeutic targets in breast cancer.ATR inhibition facilitates targeting of leukemia dependence on convergent nucleotide biosynthetic pathways.Reprofiling of full-length phosphonated carbocyclic 2'-oxa-3'-aza-nucleosides toward antiproliferative agents: Synthesis, antiproliferative activity, and molecular docking study.Genetic Variation of the Kinases that Phosphorylate Tenofovir and Emtricitabine in Peripheral Blood Mononuclear Cells.Cryo-EM structures of complex I from mouse heart mitochondria in two biochemically defined states
P2860
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P2860
description
2008 nî lūn-bûn
@nan
2008 թուականի Մայիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի մայիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Structural basis for substrate promiscuity of dCK
@ast
Structural basis for substrate promiscuity of dCK
@en
Structural basis for substrate promiscuity of dCK
@nl
type
label
Structural basis for substrate promiscuity of dCK
@ast
Structural basis for substrate promiscuity of dCK
@en
Structural basis for substrate promiscuity of dCK
@nl
altLabel
Structural Basis for Substrate Promiscuity of dCK
@en
prefLabel
Structural basis for substrate promiscuity of dCK
@ast
Structural basis for substrate promiscuity of dCK
@en
Structural basis for substrate promiscuity of dCK
@nl
P2093
P2860
P1476
Structural basis for substrate promiscuity of dCK
@en
P2093
Elisabetta Sabini
Manfred Konrad
Saugata Hazra
Stephan Ort
P2860
P304
P356
10.1016/J.JMB.2008.02.061
P407
P50
P577
2008-05-02T00:00:00Z