Elucidation of different binding modes of purine nucleosides to human deoxycytidine kinase
about
The sugar ring of the nucleoside is required for productive substrate positioning in the active site of human deoxycytidine kinase (dCK): implications for the development of dCK-activated acyclic guanine analoguesPost-translational phosphorylation of serine 74 of human deoxycytidine kinase favors the enzyme adopting the open conformation making it competent for nucleoside binding and releaseStructural and kinetic characterization of human deoxycytidine kinase variants able to phosphorylate 5-substituted deoxycytidine and thymidine analoguesExtending thymidine kinase activity to the catalytic repertoire of human deoxycytidine kinaseStructural characterization of new deoxycytidine kinase inhibitors rationalizes the affinity-determining moieties of the moleculesSelective Phosphorylation of South and North-Cytidine and Adenosine Methanocarba-Nucleosides by Human Nucleoside and Nucleotide Kinases Correlates with Their Growth Inhibitory Effects on Cultured Cells.
P2860
Elucidation of different binding modes of purine nucleosides to human deoxycytidine kinase
description
2008 nî lūn-bûn
@nan
2008 թուականի Յուլիսին հրատարակուած գիտական յօդուած
@hyw
2008 թվականի հուլիսին հրատարակված գիտական հոդված
@hy
2008年の論文
@ja
2008年論文
@yue
2008年論文
@zh-hant
2008年論文
@zh-hk
2008年論文
@zh-mo
2008年論文
@zh-tw
2008年论文
@wuu
name
Elucidation of different bindi ...... to human deoxycytidine kinase
@ast
Elucidation of different bindi ...... to human deoxycytidine kinase
@en
Elucidation of different bindi ...... to human deoxycytidine kinase
@nl
type
label
Elucidation of different bindi ...... to human deoxycytidine kinase
@ast
Elucidation of different bindi ...... to human deoxycytidine kinase
@en
Elucidation of different bindi ...... to human deoxycytidine kinase
@nl
altLabel
Elucidation of Different Bindi ...... to Human Deoxycytidine Kinase
@en
prefLabel
Elucidation of different bindi ...... to human deoxycytidine kinase
@ast
Elucidation of different bindi ...... to human deoxycytidine kinase
@en
Elucidation of different bindi ...... to human deoxycytidine kinase
@nl
P2093
P2860
P356
P1476
Elucidation of different bindi ...... to human deoxycytidine kinase
@en
P2093
Elisabetta Sabini
Manfred Konrad
Saugata Hazra
P2860
P304
P356
10.1021/JM800134T
P407
P50
P577
2008-07-24T00:00:00Z