Nonenantioselectivity property of human deoxycytidine kinase explained by structures of the enzyme in complex with L- and D-nucleosides
about
The sugar ring of the nucleoside is required for productive substrate positioning in the active site of human deoxycytidine kinase (dCK): implications for the development of dCK-activated acyclic guanine analoguesPost-translational phosphorylation of serine 74 of human deoxycytidine kinase favors the enzyme adopting the open conformation making it competent for nucleoside binding and releaseStructural and kinetic characterization of human deoxycytidine kinase variants able to phosphorylate 5-substituted deoxycytidine and thymidine analoguesStructural basis for substrate promiscuity of dCKElucidation of different binding modes of purine nucleosides to human deoxycytidine kinaseExtending thymidine kinase activity to the catalytic repertoire of human deoxycytidine kinaseMolecular basis for the lack of enantioselectivity of human 3-phosphoglycerate kinaseStructural characterization of new deoxycytidine kinase inhibitors rationalizes the affinity-determining moieties of the moleculesNucleotide promiscuity of 3-phosphoglycerate kinase is in focus: implications for the design of better anti-HIV analoguesRetrovolution: HIV-driven evolution of cellular genes and improvement of anticancer drug activationRedesigning human 2'-deoxycytidine kinase enantioselectivity for L-nucleoside analogues as reporters in positron emission tomographyStructure-guided development of deoxycytidine kinase inhibitors with nanomolar affinity and improved metabolic stability.Novel PET probes specific for deoxycytidine kinase.Structure-guided engineering of human thymidine kinase 2 as a positron emission tomography reporter gene for enhanced phosphorylation of non-natural thymidine analog reporter probe.Cell fate control gene therapy based on engineered variants of human deoxycytidine kinaseCase study on the evolution of hetero-oligomer interfaces based on the differences in paralogous proteins.Activity and mechanism of action of HDVD, a novel pyrimidine nucleoside derivative with high levels of selectivity and potency against gammaherpesvirusesEvaluation of Combinations of 4'-Ethynyl-2-Fluoro-2'-Deoxyadenosine with Clinically Used Antiretroviral Drugs.Selective Phosphorylation of South and North-Cytidine and Adenosine Methanocarba-Nucleosides by Human Nucleoside and Nucleotide Kinases Correlates with Their Growth Inhibitory Effects on Cultured Cells.Understanding the role of structural integrity and differential expression of integrin profiling to identify potential therapeutic targets in breast cancer.Bystander killing of malignant cells via the delivery of engineered thymidine-active deoxycytidine kinase for suicide gene therapy of cancer.Dual protein kinase and nucleoside kinase modulators for rationally designed polypharmacology.Synthesis, Antiviral Evaluation, and Computational Studies of Cyclobutane and CyclobuteneL-Nucleoside Analogues
P2860
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P2860
Nonenantioselectivity property of human deoxycytidine kinase explained by structures of the enzyme in complex with L- and D-nucleosides
description
2007 nî lūn-bûn
@nan
2007 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
2007 թվականի հունիսին հրատարակված գիտական հոդված
@hy
2007年の論文
@ja
2007年論文
@yue
2007年論文
@zh-hant
2007年論文
@zh-hk
2007年論文
@zh-mo
2007年論文
@zh-tw
2007年论文
@wuu
name
Nonenantioselectivity property ...... plex with L- and D-nucleosides
@ast
Nonenantioselectivity property ...... plex with L- and D-nucleosides
@en
Nonenantioselectivity property ...... plex with L- and D-nucleosides
@nl
type
label
Nonenantioselectivity property ...... plex with L- and D-nucleosides
@ast
Nonenantioselectivity property ...... plex with L- and D-nucleosides
@en
Nonenantioselectivity property ...... plex with L- and D-nucleosides
@nl
altLabel
Nonenantioselectivity Property ...... with l - and d -Nucleosides §
@en
prefLabel
Nonenantioselectivity property ...... plex with L- and D-nucleosides
@ast
Nonenantioselectivity property ...... plex with L- and D-nucleosides
@en
Nonenantioselectivity property ...... plex with L- and D-nucleosides
@nl
P2093
P2860
P356
P1476
Nonenantioselectivity property ...... plex with L- and D-nucleosides
@en
P2093
Elisabetta Sabini
Manfred Konrad
Saugata Hazra
P2860
P304
P356
10.1021/JM0700215
P407
P50
P577
2007-06-28T00:00:00Z