Fus deficiency in mice results in defective B-lymphocyte development and activation, high levels of chromosomal instability and perinatal death.
about
Human 100-kDa homologous DNA-pairing protein is the splicing factor PSF and promotes DNA strand invasionConjoint pathologic cascades mediated by ALS/FTLD-U linked RNA-binding proteins TDP-43 and FUSInduced ncRNAs allosterically modify RNA-binding proteins in cis to inhibit transcriptionA new subtype of frontotemporal lobar degeneration with FUS pathologyTLS inhibits RNA polymerase III transcriptionSignaling advances from immunogenetics to immunogenomicsFrom animal models to human disease: a genetic approach for personalized medicine in ALSMechanisms of FUS mutations in familial amyotrophic lateral sclerosisGenome-wide analysis of microRNA and mRNA expression signatures in cancerConverging mechanisms in ALS and FTD: disrupted RNA and protein homeostasisA loss of FUS/TLS function leads to impaired cellular proliferationFUS transgenic rats develop the phenotypes of amyotrophic lateral sclerosis and frontotemporal lobar degenerationThe neurogenetics of alternative splicingIdentification of an RNA binding specificity for the potential splicing factor TLSThe splicing factor U1C represses EWS/FLI-mediated transactivationPUM2, a novel murine puf protein, and its consensus RNA-binding site.EWS and FUS bind a subset of transcribed genes encoding proteins enriched in RNA regulatory functionsEbp1 sumoylation, regulated by TLS/FUS E3 ligase, is required for its anti-proliferative activity.Overexpression of human wild-type FUS causes progressive motor neuron degeneration in an age- and dose-dependent fashion.Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose).Characterization of genetic loss-of-function of Fus in zebrafish.Search for new biomarkers of gastric cancer through serial analysis of gene expression and its clinical implications.The multifunctional FUS, EWS and TAF15 proto-oncoproteins show cell type-specific expression patterns and involvement in cell spreading and stress response.FUS is phosphorylated by DNA-PK and accumulates in the cytoplasm after DNA damageYB-1 is important for late-stage embryonic development, optimal cellular stress responses, and the prevention of premature senescence.The TET family of proteins: functions and roles in disease.De novo truncating FUS gene mutation as a cause of sporadic amyotrophic lateral sclerosis.FUS-immunoreactive inclusions are a common feature in sporadic and non-SOD1 familial amyotrophic lateral sclerosis.Frameshift and novel mutations in FUS in familial amyotrophic lateral sclerosis and ALS/dementiaFus gene mutations in familial and sporadic amyotrophic lateral sclerosis.Functions of FUS/TLS from DNA repair to stress response: implications for ALS.Knockdown of the Drosophila fused in sarcoma (FUS) homologue causes deficient locomotive behavior and shortening of motoneuron terminal branches.Stem cell transplantation in neurological diseases: improving effectiveness in animal modelsBiology of EWS/ETS fusions in Ewing's family tumors.Genetic rodent models of amyotrophic lateral sclerosisProtein arginine methyltransferase 1 and 8 interact with FUS to modify its sub-cellular distribution and toxicity in vitro and in vivo.The RNA-binding protein fused in sarcoma (FUS) functions downstream of poly(ADP-ribose) polymerase (PARP) in response to DNA damageFus expression patterns in developing toothPARP-1 dependent recruitment of the amyotrophic lateral sclerosis-associated protein FUS/TLS to sites of oxidative DNA damage.Post-transcriptional mechanisms in BCR/ABL leukemogenesis: role of shuttling RNA-binding proteins.
P2860
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P2860
Fus deficiency in mice results in defective B-lymphocyte development and activation, high levels of chromosomal instability and perinatal death.
description
2000 nî lūn-bûn
@nan
2000年の論文
@ja
2000年学术文章
@wuu
2000年学术文章
@zh
2000年学术文章
@zh-cn
2000年学术文章
@zh-hans
2000年学术文章
@zh-my
2000年学术文章
@zh-sg
2000年學術文章
@yue
2000年學術文章
@zh-hant
name
Fus deficiency in mice results ...... stability and perinatal death.
@en
Fus deficiency in mice results ...... stability and perinatal death.
@nl
type
label
Fus deficiency in mice results ...... stability and perinatal death.
@en
Fus deficiency in mice results ...... stability and perinatal death.
@nl
prefLabel
Fus deficiency in mice results ...... stability and perinatal death.
@en
Fus deficiency in mice results ...... stability and perinatal death.
@nl
P2093
P2860
P356
P1433
P1476
Fus deficiency in mice results ...... stability and perinatal death.
@en
P2093
Arapovic D
P2860
P2888
P304
P356
10.1038/72842
P407
P577
2000-02-01T00:00:00Z