An RNA-binding protein gene, TLS/FUS, is fused to ERG in human myeloid leukemia with t(16;21) chromosomal translocation
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Regulation of CD44 alternative splicing by SRm160 and its potential role in tumor cell invasionTLS-ERG leukemia fusion protein inhibits RNA splicing mediated by serine-arginine proteinsRetroviral transduction of TLS-ERG initiates a leukemogenic program in normal human hematopoietic cellsThe Ews-ERG fusion protein can initiate neoplasia from lineage-committed haematopoietic cells.Mechanisms of FUS mutations in familial amyotrophic lateral sclerosisEvolutionary conservation and expression of human RNA-binding proteins and their role in human genetic diseaseA loss of FUS/TLS function leads to impaired cellular proliferationA multiplex RNA-seq strategy to profile poly(A+) RNA: application to analysis of transcription response and 3' end formation.The oncogenic TLS-ERG fusion protein exerts different effects in hematopoietic cells and fibroblasts.A domain of TEL conserved in a subset of ETS proteins defines a specific oligomerization interface essential to the mitogenic properties of the TEL-PDGFR beta oncoprotein.Dual transforming activities of the FUS (TLS)-ERG leukemia fusion protein conferred by two N-terminal domains of FUS (TLS).ERG deregulation induces PIM1 over-expression and aneuploidy in prostate epithelial cells.Animal models of soft-tissue sarcoma.Functions of FUS/TLS from DNA repair to stress response: implications for ALS.BAALC and ERG expression levels are associated with outcome and distinct gene and microRNA expression profiles in older patients with de novo cytogenetically normal acute myeloid leukemia: a Cancer and Leukemia Group B study.The Prognostic Relevance of BAALC and ERG Expression Levels in Cytogenetically Normal Pediatric Acute Myeloid Leukemia.PIM3 proto-oncogene kinase is a common transcriptional target of divergent EWS/ETS oncoproteinsWhole genome analyses of a well-differentiated liposarcoma reveals novel SYT1 and DDR2 rearrangements.Novel FUS-KLF17 and EWSR1-KLF17 fusions in myoepithelial tumors.A zebrafish transgenic model of Ewing's sarcoma reveals conserved mediators of EWS-FLI1 tumorigenesisOncogenic activation of ERG: A predominant mechanism in prostate cancer.Clinical characteristics and laboratory analyses of acute myeloid leukemia with t(16;21)(p11;q22).Hematopoietic overexpression of the transcription factor Erg induces lymphoid and erythro-megakaryocytic leukemia.YK-4-279 effectively antagonizes EWS-FLI1 induced leukemia in a transgenic mouse model.The biology of ewing sarcomaTransformation induced by Ewing's sarcoma associated EWS/FLI-1 is suppressed by KRAB/FLI-1The TEL/platelet-derived growth factor beta receptor (PDGF beta R) fusion in chronic myelomonocytic leukemia is a transforming protein that self-associates and activates PDGF beta R kinase-dependent signaling pathways.Viral Interferon Regulatory Factor 1 of Kaposi's Sarcoma-Associated Herpesvirus Interacts with a Translocation Liposarcoma Protein-Associated Serine-Arginine Protein.Acute myeloid leukemia with complex karyotypes and abnormal chromosome 21: Amplification discloses overexpression of APP, ETS2, and ERG genes.Insights into the manifestations, outcomes, and mechanisms of leukemogenesis in Down syndromeCryptic FUS-ERG fusion identified by RNA-sequencing in childhood acute myeloid leukemia.EWSR1/ELF5 induces acute myeloid leukemia by inhibiting p53/p21 pathway.ETS-related gene is a novel prognostic factor in childhood acute lymphoblastic leukemia.The spectrum of EWSR1-rearranged neoplasms at a tertiary sarcoma centre; assessing 772 tumour specimens and the value of current ancillary molecular diagnostic modalities.The complexity of NF-κB signaling in inflammation and cancer.Biochemical and bioinformatic methods for elucidating the role of RNA-protein interactions in posttranscriptional regulation.Histone deacetylase inhibitors, valproic acid and trichostatin-A induce apoptosis and affect acetylation status of p53 in ERG-positive prostate cancer cells.ERG induces a mesenchymal-like state associated with chemoresistance in leukemia cellsProgress in the molecular biology of ewing tumors.Relevance of Fusion Genes in Pediatric Cancers: Toward Precision Medicine.
P2860
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P2860
An RNA-binding protein gene, TLS/FUS, is fused to ERG in human myeloid leukemia with t(16;21) chromosomal translocation
description
1994 nî lūn-bûn
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1994 թուականի Յունիսին հրատարակուած գիտական յօդուած
@hyw
1994 թվականի հունիսին հրատարակված գիտական հոդված
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1994年の論文
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1994年学术文章
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1994年学术文章
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1994年学术文章
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1994年学术文章
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1994年学术文章
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1994年學術文章
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An RNA-binding protein gene, T ...... ;21) chromosomal translocation
@ast
An RNA-binding protein gene, T ...... ;21) chromosomal translocation
@en
An RNA-binding protein gene, T ...... ;21) chromosomal translocation
@nl
type
label
An RNA-binding protein gene, T ...... ;21) chromosomal translocation
@ast
An RNA-binding protein gene, T ...... ;21) chromosomal translocation
@en
An RNA-binding protein gene, T ...... ;21) chromosomal translocation
@nl
prefLabel
An RNA-binding protein gene, T ...... ;21) chromosomal translocation
@ast
An RNA-binding protein gene, T ...... ;21) chromosomal translocation
@en
An RNA-binding protein gene, T ...... ;21) chromosomal translocation
@nl
P2093
P3181
P1433
P1476
An RNA-binding protein gene, T ...... ;21) chromosomal translocation
@en
P2093
P304
P3181
P407
P577
1994-06-01T00:00:00Z