IL-15/IL-15Ralpha-mediated avidity maturation of memory CD8+ T cells.
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Regulating the immune system via IL-15 transpresentationInterleukin-15 rescues tolerant CD8+ T cells for use in adoptive immunotherapy of established tumorsSurvival adjustment of mature dendritic cells by IL-15.Vaccinia virus-based multivalent H5N1 avian influenza vaccines adjuvanted with IL-15 confer sterile cross-clade protection in miceLow Antigen Dose in Adjuvant-Based Vaccination Selectively Induces CD4 T Cells with Enhanced Functional Avidity and Protective Efficacy.Synergistic enhancement of CD8+ T cell-mediated tumor vaccine efficacy by an anti-transforming growth factor-beta monoclonal antibody.Using 3 TLR ligands as a combination adjuvant induces qualitative changes in T cell responses needed for antiviral protection in mice.IL-7 + IL-15 are superior to IL-2 for the ex vivo expansion of 4T1 mammary carcinoma-specific T cells with greater efficacy against tumors in vivo.Cytokines as Adjuvants for Vaccine and Cellular Therapies for Cancer.Vaccine-induced myeloid cell population dampens protective immunity to SIVPlasmid-encoded interleukin-15 receptor alpha enhances specific immune responses induced by a DNA vaccine in vivo.IL-15: a central regulator of celiac disease immunopathology.Innate and adaptive immune correlates of vaccine and adjuvant-induced control of mucosal transmission of SIV in macaques.Development of a highly efficacious vaccinia-based dual vaccine against smallpox and anthrax, two important bioterror entitiesStrategies to use immune modulators in therapeutic vaccines against cancerExpression of IL-15RA or an IL-15/IL-15RA fusion on CD8+ T cells modifies adoptively transferred T-cell function in cisInhibition of tumor growth by NK1.1+ cells and CD8+ T cells activated by IL-15 through receptor beta/common gamma signaling in trans.Safety (toxicity), pharmacokinetics, immunogenicity, and impact on elements of the normal immune system of recombinant human IL-15 in rhesus macaques.Memory generation and maintenance of CD8+ T cell function during viral persistenceMHC class I and TCR avidity control the CD8 T cell response to IL-15/IL-15Rα complex.TLR agonists and/or IL-15 adjuvanted mucosal SIV vaccine reduced gut CD4⁺ memory T cell loss in SIVmac251-challenged rhesus macaques.T-cell biology in aging, with a focus on lung disease.Impact of vaccine-induced mucosal high-avidity CD8+ CTLs in delay of AIDS viral dissemination from mucosa.Interleukin-15 Constrains Mucosal T Helper 17 Cell Generation: Influence of Mononuclear PhagocytesA push-pull vaccine strategy using Toll-like receptor ligands, IL-15, and blockade of negative regulation to improve the quality and quantity of T cell immune responses.Development of smallpox vaccine candidates with integrated interleukin-15 that demonstrate superior immunogenicity, efficacy, and safety in miceHuman Langerhans cells use an IL-15R-α/IL-15/pSTAT5-dependent mechanism to break T-cell tolerance against the self-differentiation tumor antigen WT1.Differential effects of denileukin diftitox IL-2 immunotoxin on NK and regulatory T cells in nonhuman primates.IL-15 increases the frequency of effector memory CD8+ T cells in rhesus monkeys immunized with HIV vaccine.From mice to humans - murine intelligence for human CD8+ T cell vaccine design.Spatial coordination of CD8 and TCR molecules controls antigen recognition by CD8+ T-cells.Protection against simian/human immunodeficiency virus (SHIV) 89.6P in macaques after coimmunization with SHIV antigen and IL-15 plasmid.IL-15 as a mediator of CD4+ help for CD8+ T cell longevity and avoidance of TRAIL-mediated apoptosis.Latent virus influences the generation and maintenance of CD8+ T cell memory.Alloreactive CD8 T-cell primed/memory responses and accelerated graft rejection in B-cell-deficient sensitized mice.IL-15 serves as a costimulator in determining the activity of autoreactive CD8 T cells in an experimental mouse model of graft-versus-host-like disease.Cutting edge: Dendritic cells prime a high avidity CTL response independent of the level of presented antigen.The IL-15 receptor {alpha} chain cytoplasmic domain is critical for normal IL-15Ralpha function but is not required for trans-presentationPeptide-loaded Langerhans cells, despite increased IL15 secretion and T-cell activation in vitro, elicit antitumor T-cell responses comparable to peptide-loaded monocyte-derived dendritic cells in vivo.Twelve immunotherapy drugs that could cure cancers.
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IL-15/IL-15Ralpha-mediated avidity maturation of memory CD8+ T cells.
description
article científic
@ca
article scientifique
@fr
articolo scientifico
@it
artigo científico
@pt
bilimsel makale
@tr
scientific article published on 11 October 2004
@en
vedecký článok
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vetenskaplig artikel
@sv
videnskabelig artikel
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vědecký článek
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name
IL-15/IL-15Ralpha-mediated avidity maturation of memory CD8+ T cells.
@en
IL-15/IL-15Ralpha-mediated avidity maturation of memory CD8+ T cells.
@nl
type
label
IL-15/IL-15Ralpha-mediated avidity maturation of memory CD8+ T cells.
@en
IL-15/IL-15Ralpha-mediated avidity maturation of memory CD8+ T cells.
@nl
prefLabel
IL-15/IL-15Ralpha-mediated avidity maturation of memory CD8+ T cells.
@en
IL-15/IL-15Ralpha-mediated avidity maturation of memory CD8+ T cells.
@nl
P2093
P2860
P356
P1476
IL-15/IL-15Ralpha-mediated avidity maturation of memory CD8+ T cells
@en
P2093
Jay A Berzofsky
Liyanage P Perera
SangKon Oh
Thomas A Waldmann
P2860
P304
15154-15159
P356
10.1073/PNAS.0406649101
P407
P577
2004-10-11T00:00:00Z