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Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha

Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha

http://www.wikidata.org/entity/Q24683359

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Characterization of the human ABCG1 gene: liver X receptor activates an internal promoter that produces a novel transcript encoding an alternative form of the protein Scavenger receptor SR-BI in macrophage lipid metabolism ABCA1 and scavenger receptor class B, type I, are modulators of reverse sterol transport at an in vitro blood-brain barrier constituted of porcine brain capillary endothelial cells Reduced expression of ATP-binding cassette transporter G1 increases cholesterol accumulation in macrophages of patients with type 2 diabetes mellitus Liver X receptors inhibit human monocyte-derived macrophage foam cell formation by inhibiting fluid-phase pinocytosis of LDL Synthetic LXR ligand inhibits the development of atherosclerosis in mice Oxysterol-binding protein and vesicle-associated membrane protein-associated protein are required for sterol-dependent activation of the ceramide transport protein LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes An oxysterol biomarker for 7-dehydrocholesterol oxidation in cell/mouse models for Smith-Lemli-Opitz syndrome A selective peroxisome proliferator-activated receptor delta agonist promotes reverse cholesterol transport Regulated accumulation of desmosterol integrates macrophage lipid metabolism and inflammatory responses PPARgamma1 and LXRalpha face a new regulator of macrophage cholesterol homeostasis and inflammatory responsiveness, AEBP1 Ceramide stimulates ABCA12 expression via peroxisome proliferator-activated receptor {delta} in human keratinocytes Liver X receptors contribute to the protective immune response against Mycobacterium tuberculosis in mice Synthetic LXR agonist attenuates plaque formation in apoE-/- mice without inducing liver steatosis and hypertriglyceridemia Activation of liver X receptor improves glucose tolerance through coordinate regulation of glucose metabolism in liver and adipose tissue The nuclear receptor cofactor, receptor-interacting protein 140, is required for the regulation of hepatic lipid and glucose metabolism by liver X receptor Mesenchymal Stem Cells and Metabolic Syndrome: Current Understanding and Potential Clinical Implications Mitochondrial function and regulation of macrophage sterol metabolism and inflammatory responses Feedback regulation of cholesterol uptake by the LXR-IDOL-LDLR axis X-ray crystal structure of the liver X receptor beta ligand binding domain: regulation by a histidine-tryptophan switch The three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands A lysosome-centered view of nutrient homeostasis Liver X receptors at the intersection of lipid metabolism and atherogenesis Regulated expression of the apolipoprotein E/C-I/C-IV/C-II gene cluster in murine and human macrophages. A critical role for nuclear liver X receptors alpha and beta Transcription of the vascular endothelial growth factor gene in macrophages is regulated by liver X receptors Inactivation of liver X receptor beta leads to adult-onset motor neuron degeneration in male mice Regulation of cholesterol homeostasis in macrophages and consequences for atherosclerotic lesion development Overexpression of steroidogenic acute regulatory protein increases macrophage cholesterol efflux to apolipoprotein AI An innate immunity signaling process suppresses macrophage ABCA1 expression through IRAK-1-mediated downregulation of retinoic acid receptor alpha and NFATc2 Helical apolipoproteins of high-density lipoprotein enhance phagocytosis by stabilizing ATP-binding cassette transporter A7 The fatty acid-binding protein, aP2, coordinates macrophage cholesterol trafficking and inflammatory activity. Macrophage expression of aP2 impacts peroxisome proliferator-activated receptor gamma and IkappaB kinase activities Liver X receptors regulate cholesterol homeostasis in oligodendrocytes Expression and regulation of multiple murine ATP-binding cassette transporter G1 mRNAs/isoforms that stimulate cellular cholesterol efflux to high density lipoprotein Constitutive activation of LXR in macrophages regulates metabolic and inflammatory gene expression: identification of ARL7 as a direct target Preferential ATP-binding cassette transporter A1-mediated cholesterol efflux from late endosomes/lysosomes Maintaining cholesterol homeostasis: sterol regulatory element-binding proteins Apoptotic cells trigger a membrane-initiated pathway to increase ABCA1 Nuclear receptors as drug targets for metabolic disease.Novel approaches to treating cardiovascular disease: lessons from Tangier disease.

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Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha

http://www.wikidata.org/entity/Q24683359

description

2000 nî lūn-bûn

@nan

2000 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

@hyw

2000 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2000年の論文

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2000年論文

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2000年論文

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2000年論文

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2000年論文

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2000年論文

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2000年论文

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name

Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha

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Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha

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Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha

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type

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Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha

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Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha

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Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha

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prefLabel

Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha

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Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha

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Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha

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Proceedings of the National Academy of Sciences of the United States of America

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Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha

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P2093

A Venkateswaran

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B A Laffitte

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D C Wilpitz

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P A Edwards

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P A Mak

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P Tontonoz

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P2860

Mutations in ABC1 in Tangier disease and familial high-density lipoprotein deficiency

The Tangier disease gene product ABC1 controls the cellular apolipoprotein-mediated lipid removal pathway

Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway

LXR, a nuclear receptor that defines a distinct retinoid response pathway

Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta

The orphan nuclear receptor LXRalpha is positively and negatively regulated by distinct products of mevalonate metabolism

Cloning of the cDNA for a human homologue of the Drosophila white gene and mapping to chromosome 21q22.3

ABCG1 (ABC8), the human homolog of the Drosophila white gene, is a regulator of macrophage cholesterol and phospholipid transport

Inventory and function of yeast ABC proteins: about sex, stress, pleiotropic drug and heavy metal resistance.

The gene encoding ATP-binding cassette transporter 1 is mutated in Tangier disease

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12097-12102

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scholarly article

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1210252

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10.1073/PNAS.200367697

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22

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97

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2000-10-01T00:00:00Z

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11035776

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17300

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