Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta - Wikidata - wikimedia - TriplyDB

Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta

Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta

http://www.wikidata.org/entity/Q24553340

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Role of LXRs in control of lipogenesis Characterization of the human ABCG1 gene: liver X receptor activates an internal promoter that produces a novel transcript encoding an alternative form of the protein Liver X receptor activation downregulates organic anion transporter 1 (OAT1) in the renal proximal tubule ABCA1 and scavenger receptor class B, type I, are modulators of reverse sterol transport at an in vitro blood-brain barrier constituted of porcine brain capillary endothelial cells Modulation of retinoic acid receptor-related orphan receptor alpha and gamma activity by 7-oxygenated sterol ligands Synthetic LXR ligand inhibits the development of atherosclerosis in mice Polyunsaturated fatty acids decrease the expression of sterol regulatory element-binding protein-1 in CaCo-2 cells: effect on fatty acid synthesis and triacylglycerol transport The hypocholesterolemic agent LY295427 up-regulates INSIG-1, identifying the INSIG-1 protein as a mediator of cholesterol homeostasis through SREBP LXRs control lipid-inducible expression of the apolipoprotein E gene in macrophages and adipocytes Identification of liver X receptor-retinoid X receptor as an activator of the sterol regulatory element-binding protein 1c gene promoter Regulation of mouse sterol regulatory element-binding protein-1c gene (SREBP-1c) by oxysterol receptors, LXRalpha and LXRbeta Human SREBP1c expression in liver is directly regulated by peroxisome proliferator-activated receptor alpha (PPARalpha)PPARgamma1 and LXRalpha face a new regulator of macrophage cholesterol homeostasis and inflammatory responsiveness, AEBP1 24S-hydroxycholesterol effects on lipid metabolism genes are modeled in traumatic brain injury Control of cellular cholesterol efflux by the nuclear oxysterol receptor LXR alpha Parallel SUMOylation-dependent pathways mediate gene- and signal-specific transrepression by LXRs and PPARgamma Practical uses for ecdysteroids in mammals including humans: an update Current trends in oxysterol research Mitochondrial function and regulation of macrophage sterol metabolism and inflammatory responses Regulation of the cytosolic sulfotransferases by nuclear receptors Feedback regulation of cholesterol uptake by the LXR-IDOL-LDLR axis Is Western Diet-Induced Nonalcoholic Steatohepatitis in Ldlr-/- Mice Reversible?X-ray crystal structure of the liver X receptor beta ligand binding domain: regulation by a histidine-tryptophan switch The three-dimensional structure of the liver X receptor beta reveals a flexible ligand-binding pocket that can accommodate fundamentally different ligands Crystal structure of the heterodimeric complex of LXR and RXR ligand-binding domains in a fully agonistic conformation Cytochrome P450s in the synthesis of cholesterol and bile acids--from mouse models to human diseases.Liver X receptors at the intersection of lipid metabolism and atherogenesis Molecular characterization of oxysterol binding to the Epstein-Barr virus-induced gene 2 (GPR183)Enhanced production of 24S-hydroxycholesterol is not sufficient to drive liver X receptor target genes in vivo Inactivation of liver X receptor beta leads to adult-onset motor neuron degeneration in male mice The inhibition of the human cholesterol 7alpha-hydroxylase gene (CYP7A1) promoter by fibrates in cultured cells is mediated via the liver x receptor alpha and peroxisome proliferator-activated receptor alpha heterodimer Interferon-inducible cholesterol-25-hydroxylase broadly inhibits viral entry by production of 25-hydroxycholesterol 27-Oxygenation of C27-sterols and 25-hydroxylation of vitamin D3 in kidney: cloning, structure and expression of pig kidney CYP27A Spatial distribution of the pathways of cholesterol homeostasis in human retina Defective Cytochrome P450-Catalysed Drug Metabolism in Niemann-Pick Type C Disease Sterol regulatory element-binding protein-2- and liver X receptor-driven dual promoter regulation of hepatic ABC transporter A1 gene expression: mechanism underlying the unique response to cellular cholesterol status The effect of 24S-hydroxycholesterol on cholesterol homeostasis in neurons: quantitative changes to the cortical neuron proteome Pancreatic exocrine insufficiency in LXRbeta-/- mice is associated with a reduction in aquaporin-1 expression 25-Hydroxycholesterol Protects Host against Zika Virus Infection and Its Associated Microcephaly in a Mouse Model SREBPs: activators of the complete program of cholesterol and fatty acid synthesis in the liver

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Structural requirements of ligands for the oxysterol liver X receptors LXRalpha and LXRbeta

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1999 nî lūn-bûn

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1999 թուականի Յունուարին հրատարակուած գիտական յօդուած

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1999 թվականի հունվարին հրատարակված գիտական հոդված

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1999年の論文

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1999年論文

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1999年論文

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1999年論文

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1999年論文

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1999年论文

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Structural requirements of lig ...... receptors LXRalpha and LXRbeta

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Structural requirements of lig ...... receptors LXRalpha and LXRbeta

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Structural requirements of lig ...... receptors LXRalpha and LXRbeta

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Structural requirements of lig ...... receptors LXRalpha and LXRbeta

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Structural requirements of lig ...... receptors LXRalpha and LXRbeta

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Structural requirements of lig ...... receptors LXRalpha and LXRbeta

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Proceedings of the National Academy of Sciences of the United States of America

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Structural requirements of lig ...... receptors LXRalpha and LXRbeta

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B A Janowski

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D J Mangelsdorf

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E J Corey

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G B Wisely

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M J Grogan

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S A Jones

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S A Kliewer

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P2860

ACAT-2, a second mammalian acyl-CoA:cholesterol acyltransferase. Its cloning, expression, and characterization

Activation of the nuclear receptor LXR by oxysterols defines a new hormone response pathway

LXR, a nuclear receptor that defines a distinct retinoid response pathway

Ubiquitous receptor: a receptor that modulates gene activation by retinoic acid and thyroid hormone receptors

A novel orphan receptor specific for a subset of thyroid hormone-responsive elements and its interaction with the retinoid/thyroid hormone receptor subfamily

Crystal structure of the RAR-gamma ligand-binding domain bound to all-trans retinoic acid

Crystal structure of the ligand-binding domain of the human nuclear receptor RXR-alpha

The nuclear receptor superfamily: the second decade

Relationship between the inhibition constant (K1) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

9-cis retinoic acid is a high affinity ligand for the retinoid X receptor

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266-71

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4931165

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10.1073/PNAS.96.1.266

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1

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96

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235609766

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9874807

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15128

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