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Assembly of allosteric macromolecular switches: lessons from PKA

Assembly of allosteric macromolecular switches: lessons from PKA

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E2~Ub conjugates regulate the kinase activity of Shigella effector OspG during pathogenesis Therapeutic strategies for anchored kinases and phosphatases: exploiting short linear motifs and intrinsic disorder Intrinsic disorder within an AKAP-protein kinase A complex guides local substrate phosphorylation Dynamics-Driven Allostery in Protein Kinases Single Turnover Autophosphorylation Cycle of the PKA RIIβ Holoenzyme Molecular Determinants Underlying Binding Specificities of the ABL Kinase Inhibitors: Combining Alanine Scanning of Binding Hot Spots with Network Analysis of Residue Interactions and Coevolution cAMP-dependent protein kinase (PKA) complexes probed by complementary differential scanning fluorimetry and ion mobility-mass spectrometry The Activation of c-Src Tyrosine Kinase: Conformational Transition Pathway and Free Energy Landscape.The roles of the RIIβ linker and N-terminal cyclic nucleotide-binding domain in determining the unique structures of the type IIβ protein kinase A: a small angle x-ray and neutron scattering study.Structure-based network analysis of activation mechanisms in the ErbB family of receptor tyrosine kinases: the regulatory spine residues are global mediators of structural stability and allosteric interactions.Molecular dynamics simulations and modelling of the residue interaction networks in the BRAF kinase complexes with small molecule inhibitors: probing the allosteric effects of ligand-induced kinase dimerization and paradoxical activation.Exploring Molecular Mechanisms of Paradoxical Activation in the BRAF Kinase Dimers: Atomistic Simulations of Conformational Dynamics and Modeling of Allosteric Communication Networks and Signaling Pathways.On the Dielectric "Constant" of Proteins: Smooth Dielectric Function for Macromolecular Modeling and Its Implementation in DelPhi Interplay of PKA and Rac: fine-tuning of Rac localization and signaling.Phosphorylation of ARPP19 by protein kinase A prevents meiosis resumption in Xenopus oocytes.Erythropoietin signaling regulates heme biosynthesis.NMR mapping of protein conformational landscapes using coordinated behavior of chemical shifts upon ligand binding.The reduced kinome of Ostreococcus tauri: core eukaryotic signalling components in a tractable model species Using Markov state models to develop a mechanistic understanding of protein kinase A regulatory subunit RIα activation in response to cAMP binding PRKX, a Novel cAMP-Dependent Protein Kinase Member, Plays an Important Role in Development.Protein kinase A catalytic subunit isoform PRKACA; History, function and physiology Activation of PKA leads to mesenchymal-to-epithelial transition and loss of tumor-initiating ability.Promoter hypermethylation of the phosphatase DUSP22 mediates PKA-dependent TAU phosphorylation and CREB activation in Alzheimer's disease.On the Application of Molecular-Dynamics Based Markov State Models to Functional Proteins.In vivo quantification and perturbation of Myc-Max interactions and the impact on oncogenic potential.Computational study of the "DFG-flip" conformational transition in c-Abl and c-Src tyrosine kinases.Systematic identification of signal integration by protein kinase A.Inactivation of a Gα(s)-PKA tumour suppressor pathway in skin stem cells initiates basal-cell carcinogenesis.High-resolution crystal structure of cAMP-dependent protein kinase from Cricetulus griseus.PKA-type I selective constrained peptide disruptors of AKAP complexes In-vivo detection of binary PKA network interactions upon activation of endogenous GPCRs Allostery through the computational microscope: cAMP activation of a canonical signalling domain Protein Kinase A Opposes the Phosphorylation-dependent Recruitment of Glycogen Synthase Kinase 3β to A-kinase Anchoring Protein 220 Heat dissipation guides activation in signaling proteins Functional and Structural Mimicry of Cellular Protein Kinase A Anchoring Proteins by a Viral Oncoprotein An Isoform-Specific Myristylation Switch Targets Type II PKA Holoenzymes to Membranes Substrate Affinity Differentially Influences Protein Kinase C Regulation and Inhibitor Potency.Mechanisms of cyclic AMP/protein kinase A- and glucocorticoid-mediated apoptosis using S49 lymphoma cells as a model system Transcriptomic characterization of fibrolamellar hepatocellular carcinoma.Structural insight into the mechanism of synergistic autoinhibition of SAD kinases

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Assembly of allosteric macromolecular switches: lessons from PKA

http://www.wikidata.org/entity/Q26852228

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2012 nî lūn-bûn

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2012 թուականի Հոկտեմբերին հրատարակուած գիտական յօդուած

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2012 թվականի հոտեմբերին հրատարակված գիտական հոդված

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2012年の論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年論文

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2012年论文

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Assembly of allosteric macromolecular switches: lessons from PKA

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Assembly of allosteric macromolecular switches: lessons from PKA

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Assembly of allosteric macromolecular switches: lessons from PKA

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Assembly of allosteric macromolecular switches: lessons from PKA

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Assembly of allosteric macromolecular switches: lessons from PKA

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Assembly of allosteric macromolecular switches: lessons from PKA

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Assembly of allosteric macromolecular switches: lessons from PKA

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Assembly of allosteric macromolecular switches: lessons from PKA

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Assembly of allosteric macromolecular switches: lessons from PKA

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Nature Reviews Molecular Cell Biology

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Assembly of allosteric macromolecular switches: lessons from PKA

@en

P2093

Alexandr P. Kornev

http://www.w3.org/2001/XMLSchema#string

Ping Zhang

http://www.w3.org/2001/XMLSchema#string

Ronit Ilouz

http://www.w3.org/2001/XMLSchema#string

Susan S. Taylor

http://www.w3.org/2001/XMLSchema#string

P2860

Structural and functional diversity of the microbial kinome

The protein kinase complement of the human genome

A-kinase-interacting protein localizes protein kinase A in the nucleus

Hippocampal long-term depression and depotentiation are defective in mice carrying a targeted disruption of the gene encoding the RI beta subunit of cAMP-dependent protein kinase

Purification of the regulatory component of adenylate cyclase

A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase C

The molecular basis for protein kinase A anchoring revealed by solution NMR

PKA-I holoenzyme structure reveals a mechanism for cAMP-dependent activation

PKA Type II Holoenzyme Reveals a Combinatorial Strategy for Isoform Diversity

Crystal structure of the catalytic subunit of cyclic adenosine monophosphate-dependent protein kinase

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646-58

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scholarly article

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1907541

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10.1038/NRM3432

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10

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13

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2012-10-01T00:00:00Z

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230884412

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1035463962

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22992589

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3985763

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